A5028452747- Vascular Procedures and Complications
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Central Venous Catheters and Hemodialysis
- Pain Management and Treatment
- Cell Adhesion Molecules Research
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Economic Sanctions and International Relations
- Climate Change and Health Impacts
- Cardiovascular Issues in Pregnancy
- Pain Mechanisms and Treatments
- Transplantation: Methods and Outcomes
- Market Dynamics and Volatility
- Antiplatelet Therapy and Cardiovascular Diseases
- Tissue Engineering and Regenerative Medicine
- Global trade and economics
- Health disparities and outcomes
Saint Luke's Hospital
2012-2020
University of Missouri–Kansas City
2012-2020
Missouri Heart Center
2012-2017
Clinical Research Institute
2013
Mayo Clinic in Arizona
2013
Duke University Hospital
2013
Duke Medical Center
2013
NewYork–Presbyterian Hospital
2013
Cornell University
2013
Mayo Clinic in Florida
2013
Background— Radial access for percutaneous coronary intervention (r-PCI) is associated with reduced vascular complications; however, previous reports have shown that <2% of (PCI) procedures in the United States are performed via radial approach. Our aims were to evaluate temporal trends r-PCI and compare procedural outcomes between transfemoral PCI. Methods Results— We conducted a retrospective cohort study from CathPCI registry (n=2 820 874 1381 sites) January 2007 September 2012....
Bleeding is a common, noncardiac, preventable complication of percutaneous coronary intervention. We compared the relative safety radial access and bivalirudin in intervention.From CathPCI Registry, we determined association between site arterial access, bivalirudin, periprocedural bleeding rates 501 017 patients. Radial patients receiving heparin (radial group) were with those combination group). Femoral who had vascular closure device served as reference group (femoral An inverse...
Local delivery of therapeutic agents into the myocardium is limited by suboptimal imaging. We evaluated feasibility and accuracy live 3D echo to guide left ventricular endomyocardial injection. An intramyocardial injection catheter was positioned in ventricle five healthy Yorkshire pigs using fluoroscopy. All other manipulations were performed with biplane guidance. In each animal, a total 12 injections (volume, 50–100 μl) contrast mixed blue tissue dye performed. Four injections, 10 mm...
Abstract Bone marrow cells (BMC) labeled with iron particles can be injected into the heart and detected MRI. Improvement in conspicuity of labelled would advantageous. This study examined if double contrast oxide Gd‐DTPA enhances cell MRI after transvascular transplantation myocardial infarction. Ten pigs week‐old infarction had peri‐infarct delivery microspheres alone (Group I, n = 3) or mixed iron‐labeled BMCs II, 7). Gradient‐echo before 1 min systemic administration produced regions...
Abstract We compared two routes for myocardial delivery of therapeutics, transendocardial (TE) with an intramyocardial injection catheter, and retrograde coronary venous (RCV) a balloon occlusion catheter in the interventricular vein. Methods: TE RCV 15 μm, neutron‐activatable microspheres was healthy pigs (Group I, n = 3), 1‐week‐old infarction (MI; group II, 5), 2‐weeks‐old MI (group III, 4). The induced by 1‐hr LAD. Both methods were same animal using different microspheres. allowed...
Abstract Background. Prior experimental and clinical studies have drawn disparate conclusions regarding the effects of transmyocardial laser revascularization (TMR) on regional cardiac innervation in treated regions. Regional afferent denervation has been proposed as a potential mechanism action procedure, although this yet remains unproven. The purpose present study was to evaluate myocardial sympathetic both early (3 days) late (6 months) after TMR. Methods. Mini-swine group were...
Stress-induced release of IL-1alpha and fibroblast growth factor-1 is dependent on intracellular copper a major driver neointimal hyperplasia. Therefore, we assessed the effect tetrathiomolybdate (TTM), clinically proven chelator, in-stent restenosis. Nine pigs were treated with TTM (5 mg/kg po) twice daily for 2 wk before stent implantation 4 thereafter, nine served as controls. In-stent restenosis was by quantitative coronary angiography (QCA), intravascular ultrasound (IVUS),...
Vein graft atherosclerosis is the major limitation of arterial bypass surgery. This study was carried out to determine if number microvessels per area intimal hyperplasia correlated with vein disease. grafts (n=24, age range 2-19 years) were taken from 22 patients undergoing redo-coronary artery Mean 68 6 9 years; 92% males. Samples divided into three groups (n=8 group): in group I segments without angiographic or histologic disease, II and III significant stenosis, (group II) III) atheroma....