A5042420361- Single-cell and spatial transcriptomics
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Bacterial Genetics and Biotechnology
- Advanced Proteomics Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Insect and Arachnid Ecology and Behavior
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Advanced Biosensing Techniques and Applications
- Adipose Tissue and Metabolism
- Gene Regulatory Network Analysis
- Viral gastroenteritis research and epidemiology
- Lipid metabolism and biosynthesis
- Biochemical Analysis and Sensing Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Sensory Analysis and Statistical Methods
- Insect Utilization and Effects
- Color perception and design
École Polytechnique Fédérale de Lausanne
2017-2025
SIB Swiss Institute of Bioinformatics
2019-2025
Center for Systems Biology
2018-2019
Harvard University
2018-2019
University of Lausanne
2019
German Cancer Research Center
2014
Heidelberg University
2014
Food presents a multisensory experience, with visual, taste, and olfactory cues being important in allowing an animal to determine the safety nutritional value of given substance. Texture, however, remains surprisingly unexplored aspect, despite providing key information about state food through properties such as hardness, liquidity, granularity. perception is achieved by specialised sensory neurons, which themselves are defined receptor genes they express. While it was assumed that neurons...
Engineering synthetic circuits into intestinal bacteria to sense, record, and respond
Analysis of large-scale proteomic data sets requires specialized software tools, tailored toward the requirements individual approaches. Here we introduce an extension open-source solution for analyzing reverse phase protein array (RPPA) data. The R package RPPanalyzer was designed preprocessing followed by basic statistical analyses and visualization. In this update, merged relevant steps into a single user-friendly function included new method background noise correction as well methods...
Single-cell RNA-sequencing (scRNA-seq) has revolutionized biomedical research by enabling the in-depth analysis of cell-to-cell heterogeneity tissues with unprecedented resolution.
Abstract Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. However, the regulatory mechanisms underlying brown adipogenesis are still poorly understood. To address this, we profiled transcriptome and chromatin state during mouse fat cell differentiation, revealing extensive gene expression changes remodeling, especially first day post-differentiation. identify putatively causal regulators, performed...
The genome of the murine commensal strain Escherichia coli NGF-1 contains a 5.03-Mbp chromosome and plasmids 40.2 kbp 8.56 kbp. efficiently colonizes mouse gut is genetically tractable. sequence reported here facilitates genetic engineering research in models healthy diseased intestine.
Abstract Single-cell RNA-sequencing (scRNA-seq) has transformed our ability to resolve cellular properties across systems. However, current scRNA-seq platforms are one-size-fits-all approaches that tailored toward large cell inputs (> 1,000 cells), rendering them inefficient and costly when processing small, individual tissue samples. This important drawback tends be resolved by loading bulk samples, but this yields confounded mosaic population read-outs. To overcome these technological...
Summary Food presents a multisensory experience, with visual, taste, and olfactory cues being important in allowing an animal to determine the safety nutritional value of given substance 1 . Texture, however, remains surprisingly unexplored aspect, despite providing key information about state food through properties such as hardness, liquidity, granularity. perception is achieved by specialised sensory neurons, which themselves are defined receptor genes they express. While it was assumed...
Abstract The ability to evaluate food palatability is innate in all animals, ensuring their survival. external taste organ Drosophila larvae composed of only few sensory neurons but enables discrimination between a wide range chemicals and displays high complexity receptor gene expression physiological response profile. It remains largely unknown how the discrepancy small neuronal number perception large space genetically physiologically resolved. We tackled dissection coding at level with...
ABSTRACT The composition and function of the gut microbiota are strongly associated with human health, dysbiosis is linked to an array diseases, ranging from obesity diabetes infection inflammation. Engineering synthetic circuits into bacteria sense, record respond in vivo signals a promising new approach for diagnosis, treatment prevention disease. Here, we repurpose bacterial memory circuit rapidly screen discover -responsive biosensors commensal Escherichia coli . We develop pipeline...