A5077040567- Advanced Chemical Physics Studies
- Catalytic Processes in Materials Science
- Asymmetric Synthesis and Catalysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Reactions
- Catalysis and Oxidation Reactions
- Nanomaterials for catalytic reactions
- Asthma and respiratory diseases
- Catalysts for Methane Reforming
- CO2 Reduction Techniques and Catalysts
- Organic Chemistry Cycloaddition Reactions
- Asymmetric Hydrogenation and Catalysis
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Microwave-Assisted Synthesis and Applications
- Covalent Organic Framework Applications
- Ionic liquids properties and applications
- Membrane Separation and Gas Transport
- nanoparticles nucleation surface interactions
- Carbon dioxide utilization in catalysis
- Axial and Atropisomeric Chirality Synthesis
- Synthesis of Tetrazole Derivatives
Budapest University of Technology and Economics
2016-2024
Gedeon Richter (Hungary)
2024
In this work we introduce a sustainable membrane-based synthesis–separation platform for enantioselective organocatalysis. An azido derivatized cinchona-squaramide bifunctional catalyst was synthesized and subsequently grafted to the surface of polybenzimidazole-based nanofiltration membrane. The favorable effect covalent grafting—due change in geometry increased secondary interactions—on catalytic activity due conformational changes confirmed by quantum chemical calculations. Asymmetric...
This work presents a cyclodextrin-enhanced organocatalytic method from molecular to process design. Cinchona-thiourea and -squaramide catalysts were covalently anchored inherently large, stable well-defined permethyl-β-cyclodextrins. The asymmetric catalysis was successfully demonstrated on the Michael reaction of 1,3-diketones trans-β-nitrostyrene. Both emerging green conventional solvents screened for addition (up 99% ee), Kamlet–Taft solvent parameters correlated enantioselectivity....
Activation of CO 2 is the first step towards its reduction to more useful chemicals.
Steroid-based histamine H3 receptor antagonists (d-homoazasteroids) were designed by combining distinct structural elements of HTS hit molecules. They characterized, and several them displayed remarkably high affinity for receptors with antagonist/inverse agonist features. Especially, the 17a-aza-d-homolactam chemotype demonstrated excellent H3R activity together significant in vivo antagonism. Optimization was initiated special emphasis on elimination hERG muscarinic affinity. Additionally,...
Highly active catalytic clusters are observed during the reaction mechanism study of copper cluster Cux (x = 4–15) catalyzed N2O + CO → N2 CO2 reaction. It was shown that adsorbs on without an activation barrier and nitrogen–oxygen bond is broken next step. The analysis chemical bonding showed oxide ion formation important driving force Among different Cu12 most as cleaved energy barrier, while nitrogen molecule eliminated. resulting reduced easily with carbon-monoxide. elimination thus...
Binaphthyl-cinchona squaramide and thiosquaramide were applied as organocatalysts in three types of asymmetric reactions with excellent yields enantioselectivities.
The catalytic activity of metal clusters can be easily tuned by their size, charge state, or the introduction dopant atoms. Here, dopant-, charge- and size-dependent propene adsorption on gold (Au n +) yttrium doped n-1Y+) (n = 4-20) was investigated using combined gas-phase reaction studies density functional theory computations. increased transfer between cluster in cationic considerably enhances binding both pure yttrium-doped species, compared to neutral counterparts, while...
Numerous cinchona organocatalysts with different substituents at their quinuclidine unit have been described and tested, but the effect of those saturation has not examined before. This work presents synthesis four widely used cinchona-based organocatalyst classes (hydroxy, amino, squaramide, thiourea) on (ethyl, vinyl, ethynyl) started from quinine, most easily available derivative. Big differences were found in basicity by measuring pKa values twelve catalysts six solvents. The was testing...
The dopant and size-dependent propene adsorption on neutral gold (Au
The asymmetric stretch vibration of CO 2 on different Cu n + cluster sizes, with = 1–10, is spectroscopically investigated. strongest binding found , decreasing size, as reflected in the frequency shift.