Santosh Kumar Bikkarolla

ORCID: 0000-0001-5715-0323
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Advanced biosensing and bioanalysis techniques
  • Graphene research and applications
  • Biosensors and Analytical Detection
  • Electrocatalysts for Energy Conversion
  • Conducting polymers and applications
  • Bacterial biofilms and quorum sensing
  • Advanced battery technologies research
  • Fuel Cells and Related Materials
  • Advanced Sensor and Energy Harvesting Materials
  • Bacterial Genetics and Biotechnology
  • Nanopore and Nanochannel Transport Studies
  • Vibrio bacteria research studies
  • Genomics and Phylogenetic Studies
  • Advanced Biosensing Techniques and Applications
  • Diamond and Carbon-based Materials Research
  • Microfluidic and Capillary Electrophoresis Applications
  • Analytical Chemistry and Chromatography
  • Fiber-reinforced polymer composites
  • Microfluidic and Bio-sensing Technologies
  • Lipid Membrane Structure and Behavior
  • Laser-Ablation Synthesis of Nanoparticles
  • Membrane Separation Technologies
  • Nutritional Studies and Diet
  • Retinal Imaging and Analysis

University of Ulster
2014-2022

Chalmers University of Technology
2017-2021

TIFR Centre for Interdisciplinary Sciences
2017

Newtown Hospital
2014-2016

National University of Singapore
2012

A 3D hierarchical Mn<sub>3</sub>O<sub>4</sub>nanoflake structure supported on nitrogenated reduced graphene oxide (NrGO), with excellent oxygen reduction in alkaline medium, was developed by electrodeposition. High performance is attributed to poor nanoflake crystallinity and strong nanoflake–NrGO coupling.

10.1039/c4ta02279c article EN Journal of Materials Chemistry A 2014-01-01

We show that a partially reduced graphene oxide electrocatalyst, synthesized by electrochemical reduction of (GO), displays significantly enhanced catalytic activity towards the oxygen reaction (ORR) in alkaline solutions compared to starting GO. The partial GO was confirmed X-ray diffraction and photoelectron spectroscopy. Electrochemical impedance spectroscopy (EIS) verified electron transfer ability electrochemically (ErGO) resultant ErGO electrode showed capacitance an ORR onset...

10.1039/c4fd00088a article EN Faraday Discussions 2014-01-01

The global spread of antibiotic resistance among Enterobacteriaceae is largely due to multidrug plasmids that can transfer between different bacterial strains and species. Horizontal gene complicate hospital outbreaks cause problems in epidemiological tracing, since tracing usually based on clonality. We have developed a method, optical DNA mapping combined with Cas9-assisted identification genes, which used here characterize during an extended-spectrum β-lactamase (ESBL)-producing outbreak...

10.1128/mbio.00347-19 article EN cc-by mBio 2019-07-08

Au nanoparticles (AuNPs) have been used as signal reporters in colorimetric lateral flow immunoassays (LFAs) for decades. However, it remains a major challenge to significantly improve the detection sensitivity of traditional LFAs due low brightness AuNPs. As an alternative approach, we overcome this problem by utilizing 150 nm gold nanoshells (AuNSs) that were engineered coating low-density silica with thin layer gold. AuNSs are dark green, 14 times larger surface area, and approximately 35...

10.3390/bios12030182 article EN cc-by Biosensors 2022-03-19

A colloidal gold-based lateral flow immunoassay was developed for the rapid quantitative detection of Cystatin-C in serum and whole blood. This device has an assay time 15 min, making it a convenient point-of-care diagnostic tool. The quantification range spanning from 0.5 to 7.5 µg/mL, with lower limit at 0.18 µg/mL. To validate its accuracy, test compared standard nephelometric immunoassay, results exhibited robust linear correlation adjusted r

10.3390/bios14010030 article EN cc-by Biosensors 2024-01-08

Abstract The development of a low‐cost and disposable biosensor platform for the sensitive rapid detection microRNAs (miRNAs) is great interest healthcare, pharmaceuticals, medical science. We designed an impedimetric biosensing using Chitosan (CHIT)/nitrogen doped reduced graphene oxide (NRGO) conductive composite to modify surface pencil graphite electrodes (PGE) miRNAs. An initial optimisation protocol involved investigation effect NRGO concentration miR 660 DNA probe on response modified...

10.1002/elan.201700663 article EN Electroanalysis 2018-01-19

In this article, organic and polymeric materials, printing technology, sensing principles are investigated toward a reliable printed wearable pH sensor realized on textiles. A literature study experimental work of three different material‐based sensors their corresponding measurement methods systematically made. Initially, the sensors, conductometric PEDOT:PSS sensor, voltametric carbon‐alizarin potentiometric graphene/polyaniline (PANI) selected based specific established criteria...

10.1002/adem.202101087 article EN Advanced Engineering Materials 2021-11-23

Decorating graphene nanoflakes with nanocrystalline diamond gives superior functioning for microplasma devices long lifetime stability plasma illumination performances.

10.1039/c6ra07116c article EN RSC Advances 2016-01-01

We report a self-sufficient microfluidic paper-based lateral flow immunoassay device (μLFD) for highly sensitive detection of the thyroid-stimulating hormone (TSH). Fabrication paper microchannels involves engraving nitrocellulose membrane with CO2 laser to create narrow paths, which constrain fluid over test zone. The proposed microchannel modified devices were studied TSH using gold nanoparticles as labels. effect such LFDs has led an improvement in sensitivity by nine times and limit 6.6...

10.1063/5.0026047 article EN cc-by AIP Advances 2020-12-01

The output from whole genome sequencing is a set of contigs, i.e. short non-overlapping DNA sequences (sizes 1-100 kilobasepairs). Piecing the contigs together an especially difficult task for previously unsequenced DNA, and may not be feasible due to factors such as lack sufficient coverage or larger repetitive regions which generate gaps in final sequence. Here we propose new method scaffolding contigs. proposed uses densely labeled optical barcodes competitive binding experiments...

10.1371/journal.pone.0193900 article EN cc-by PLoS ONE 2018-03-09

The site-specific interactions of polar solvents (such as tetrahydrofuran (THF)) with fluorographene oxide (FGO), leading to its defluorination, are demonstrated. Density functional theory (DFT) studies conducted understand the various graphene and FGO, defluorination FGO during interaction THF is demonstrated experimentally, shown by change in color black. As a service our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be...

10.1002/ppsc.201600346 article EN Particle & Particle Systems Characterization 2017-03-07

This paper presents a plasma display device (PDD) based on laser-induced graphene nanoribbons (LIGNs), which were directly fabricated polyimide sheets. Superior field electron emission (FEE) characteristics, viz. low turn-on of 0.44 V/μm and large enhancement factor 4578, achieved for the LIGNs. Utilizing LIGNs as cathode in PDD showed excellent illumination characteristics with prolonged lifetime stability. Moreover, LIGN cathodes laser-patternable. Such superior performance LIGN-based PDDs...

10.3390/nano9101493 article EN cc-by Nanomaterials 2019-10-19

Karl Coleman opened the discussion of paper by Mary Chan-Park: Is source SWCNTs important? I ask this in context that ratio SC to metallic will be different from suppliers and methods production. Chan-Park responded: We have not tried o

10.1039/c4fd90046d article EN Faraday Discussions 2014-01-01

Nanochannels provide means for detailed experiments on the effect of confinement biomacromolecules, such as DNA. We here introduce a model complete unfolding DNA from circular to linear configuration. Two main ingredients are entropic force well friction coefficient process, and we describe associated dynamics by non-linear Langevin equation. By analyzing experimental data where molecules photo-cut unfolded inside nanochannel, our allows us extract values first time. In order numerical these...

10.1063/1.5051319 article EN The Journal of Chemical Physics 2018-12-04

Carbapenem-resistant Klebsiella pneumoniae are a major global threat in healthcare facilities. The propagation of carbapenem resistance determinants can occur through vertical transmission, with genetic elements being transmitted by the host bacterium, or horizontal same transferred among distinct bacterial hosts. This work aimed to track transmission K . facility. study involved polyphasic approach based on conjugation assays, phenotype and genotype analyses, whole genome sequencing,...

10.1371/journal.pone.0247058 article EN cc-by PLoS ONE 2021-02-26

Large-scale genomic alterations play an important role in disease, gene expression, and chromosome evolution. Optical DNA mapping (ODM), commonly categorized into sparsely-labelled ODM densely-labelled ODM, provides sequence-specific continuous intensity profiles (DNA barcodes) along single molecules is a technique well-suited for detecting such alterations. For barcodes, the possibility to detect large has been investigated extensively, while barcodes have not received as much attention. In...

10.1371/journal.pone.0259670 article EN cc-by PLoS ONE 2021-11-05
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