A5112602018- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic and Kidney Cyst Diseases
- MicroRNA in disease regulation
Hebei Medical University
2025
National Cheng Kung University
2021
Abstract The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that DNA-PK-p53 cascade induced primary cilia formation (ciliogenesis), thus maintaining response under genotoxic stress. Treatment with drugs (etoposide, neocarzinostatin, hydroxyurea, or cisplatin) led to ciliogenesis in human retina (RPE1), trophoblast (HTR8), lung (A459), and mouse Leydig...
BACKGROUND: Phenotypic switching of vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia, is a fundamental cause remodeling diseases such as atherosclerosis and hypertension. Novel hidden proteins encoded by circular RNAs play crucial roles in disease progression, yet their involvement has not been comprehensively studied. This study identifies novel protein derived from RNA VSMCs demonstrates its potential role regulating remodeling. METHODS: Cell proliferation assays...