A5101776549- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Metastasis and carcinoma case studies
- Photoacoustic and Ultrasonic Imaging
- Gastrointestinal Tumor Research and Treatment
- Myasthenia Gravis and Thymoma
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
Jikei University School of Medicine
2024-2025
Tachikawa Hospital
2021-2024
Keio University
2010-2023
University Health Network
2018-2022
Toronto General Hospital
2017-2022
Ashikaga Red Cross Hospital
2021
Tokyo Metropolitan Komagome Hospital
2020-2021
University of Toronto
2018
Health Net
2018
Institute for Advanced Medical Research
2016-2017
Recently, an association between tumor infiltrating Forkhead box P3 regulatory T cells (T reg ) and unfavorable prognosis has been clinically shown in some cancers, but the mechanism of induction microenvironment remains uncertain. The aims present study were to examine relationship patient outcome investigate whether is influenced by characteristics cancer‐associated fibroblasts (CAF) lung adenocarcinoma. numbers both stroma nest counted 200 consecutive pathological stage I invasive...
Abstract OBJECTIVES This study retrospectively analysed the effect of number resected pulmonary segments on surgical outcomes patients with non-small cell lung cancer (NSCLC) undergoing anatomical resection. METHODS We examined who underwent lobectomy or segmentectomy for NSCLC between January 2016 and June 2021. compared ≤3 segment group (Group A) ≥4 B). Lung functions were evaluated by comparing preoperative 6-month postoperative periods. Comprehensive status, including osteoporosis,...
Although the incidence of peripheral squamous cell carcinomas (p-SqCCs) lung has increased over recent years, clinicopathological factors influencing prognosis resected p-SqCCs remain unclear.We examined 280 patients who underwent complete resection SqCCs and analyzed features in relation to their overall survival (OS) recurrence-free (RFS) according primary location.Multivariate analysis all stages revealed that high serum carcinoma antigen (SCC) level (OS; p < 0.01, RFS; 0.01), vascular...
Pulmonary metastasectomies are performed for a variety of cancers, though few reports have examined their merit head and neck cancers. This study the relationship between clinical pathological characteristics survival after resection lung metastases these cancers.Between 1986 2013, 34 patients presenting with pulmonary primary or cancers underwent surgical resections at our institution. We retrospectively analyzed patients' metastasectomy in search adverse prognostic factors.The sites cancer...
Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established modality for the assessment of mediastinal and hilar adenopathy. To overcome sampling limitations standard 21- 22-gauge EBUS-TBNA needles, a new flexible 19-gauge (Flex 19G) was developed. Methods: We performed retrospective analysis patients who underwent with Flex 19G needle. A 22G always used first cytology, followed by needle, either early version (Oct/2014–Sep/2015) or final...
Abstract While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptive immune response is desirable, as it may control growth of nonirradiated distant disease. Previously, we developed porphyrin lipoprotein (PLP), ∼20 nm nanoparticle photosensitizer, and observed that not only efficiently eradicated primary VX2 buccal carcinomas rabbits, but also induced regression metastases draining lymph node. We hypothesized PLP-mediated PDT...
<b><i>Background:</i></b> Programmed death ligand-1 (PD-L1) assessed by immunohistochemistry (IHC) is used as biomarker for pembrolizumab therapy in advanced stage lung cancer patients. However, data permitting direct performance comparison between cytology and surgical specimen types are limited since both specimens from a single tumor site infrequently available. In addition, alcohol fixation with requires technical validation of the PD-L1 IHC assay before clinical...
Hair follicle (HF) formation and growth are sustained by epithelial-mesenchymal interaction via factors cytokines. Pivotal roles of FGFs on HF regeneration neogenesis have been reported mainly in rodent models. FGF expression is regulated upstream pathways, represented canonical WNT signaling; however, how influence human folliculogenesis remains elusive. The aim this study to assess if scalp-derived fibroblasts (sFBs) able modulate their profile response activation evaluate the...
Purpose Diagnosis and resection of indeterminate pulmonary nodules (IPNs) is a growing challenge with increased utilization chest computed tomography. Photoacoustic (PA) -guided surgical local injection indocyanine green (ICG) may have utility for IPNs that are suspicious lung cancer. This preclinical study explores the potential PA imaging (PAI) to detect ICG-labeled tumors. Materials methods ICG uptake by H460 cancer cells was evaluated in vitro. A phantom performed analyze signal...