A5013293830- Photodynamic Therapy Research Studies
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Psoriasis: Treatment and Pathogenesis
- Cancer Research and Treatments
- Biological Stains and Phytochemicals
- Glutathione Transferases and Polymorphisms
- Plant-Derived Bioactive Compounds
- Hematopoietic Stem Cell Transplantation
- Cutaneous lymphoproliferative disorders research
- Infectious Diseases and Mycology
- Olfactory and Sensory Function Studies
- Fibroblast Growth Factor Research
- Vitamin D Research Studies
- Urban Green Space and Health
- Phytochemicals and Antioxidant Activities
- Wound Healing and Treatments
- Bee Products Chemical Analysis
- Inflammatory mediators and NSAID effects
Universidad Autónoma de Madrid
2020-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2024
Universitat Politècnica de Catalunya
2017
Skin is being increasingly exposed to artificial blue light due the extensive use of electronic devices. This, together with recent observations reporting that light-also known as high-energy visible light-can exert cytotoxic effects associated oxidative stress and promote hyperpigmentation, has sparked interest in its potential harmful on skin. The photoprotective properties new extracts different botanicals antioxidant activity are therefore studied. Deschampsia antarctica (Edafence®,...
As an important component of tumor microenvironment, cancer-associated fibroblasts (CAFs) have lately gained prominence owing to their crucial role in the resistance therapies. Photodynamic therapy (PDT) stands out as a successful therapeutic strategy treat cutaneous squamous cell carcinoma. In this study, we demonstrate that transforming growth factor β1 (TGFβ1) cytokine secreted by CAFs isolated from patients with SCC can drive PDT epithelial cells. To end, obtained situ cSCC were firstly...
Cancer metabolic reprogramming promotes resistance to therapies. In this study, we addressed the role of Warburg effect in photodynamic therapy (PDT) skin squamous cell carcinoma (sSCC). Furthermore, assessed metformin treatment, an antidiabetic type II drug that modulates metabolism, as adjuvant PDT.For that, have used two human SCC lines: SCC13 and A431, called parental (P) from these lines generated corresponding PDT resistant cells (10GT).Here, show 10GT induced enhanced aerobic...
This comprehensive review delves into various immunotherapeutic approaches for the management of actinic keratoses (AKs), precancerous skin lesions associated with UV exposure. Although there are treatments whose main mechanism action is immune modulation, such as imiquimod or diclofenac, other treatments, apart from their effect on dysplastic cells, exert some immunological action, which in end contributes to efficacy. While like 5-fluorouracil, imiquimod, photodynamic therapy, and...
Exposure to sun and especially ultraviolet radiation (UVR) exerts well known detrimental effects on skin which are implicated in malignancy. UVR induces production of cyclobutane pyrimidine dimers (CPDs), immediately during exposure even hours after the exposure, these latter being called dark-CPDs, as consequence different reactive species that formed. Fernblock® (FB), an aqueous extract Polypodium leucotomos, has proven have photoprotective antioxidant skin. The aim our work was...
Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor antioxidant activity. The effects of an extract from were assessed by storage model food oil-in-water emulsions with analysis primary secondary oxidation products. capacity the was evaluated diphenylpicrylhydrazyl (DPPH), Trolox equivalent (TEAC), oxygen radical absorbance (ORAC) ferric reducing power (FRAP) assays electron paramagnetic resonance (EPR)...
Abstract Blue light exposure of the ocular apparatus is currently rising. This has motivated a growing concern about potential deleterious effects on different eye structures. To address this, ARPE-19 cells were used as model retinal pigment epithelium and subjected to cumulative expositions blue light. The most relevant cellular events previously associated with blue-light-induced damage assessed, including alterations in cell morphology, viability, proliferation, oxidative stress,...
Photodynamic therapy (PDT) is a widely-used non-surgical treatment for non-melanoma skin cancers, including basal cell carcinoma (BCC), actinic keratoses (AK), and Bowen's disease (BD). PDT has high success rates, but various factors, can influence response. This study investigates the clinical, histological, molecular factors that affect efficacy of methyl aminolevulinate (MAL-PDT) BCC BD.
Squamous Cell Carcinoma (SCC) is a subtype of Non-Melanoma Skin Cancer, the most common group malignancies worldwide. Photodynamic therapy (PDT) non-invasive treatment approved for specific subtypes SCC. Some resist PDT, forming more aggressive tumors and multiple relapses. Thus, new approaches aimed at optimizing response to PDT are needed. The mTORC1 inhibitor rapamycin, also known as Sirolimus (SRL), interferes with protein synthesis cell metabolism. use SRL an immunosuppressant...
Photoaging and carcinogenesis are facilitated by oxidative stress, inflammation, angiogenesis, extracellular matrix (ECM) remodeling. Oxidative effects include DNA damage, membrane oxidation, lipid peroxidation, alterations in the expression of p53 antioxidant enzymes. The inflammatory angiogenesis mediators interleukin-1, tumor necrosis factor-α, interleukin-8, transforming growth factor-β, vascular endothelial factor. ECM remodeling includes organization collagen, elastin,...
Oxidative stress is a harmful effect induced on the skin by polycyclic aromatic hydrocarbons (PAH), including benzo[a]pyrene (BaP) air pollutants. This amplified additive damaging of sun, especially through UVA light component. Besides being one main compounds that make up pollution, BaP can also be found in tar, tobacco smoke, and various foods. In addition to its direct carcinogenic potential, act as photosensitizer absorbing sunlight range thus generating ROS 8-hydroxy-2'-deoxyguanosine...
In the present study, we aim to understand implications of transforming growth factor β1 secreted by cancer-associated fibroblasts (CAFs) in resistance cutaneous squamous cell carcinoma (cSCC) cells photodynamic therapy (PDT), as well effects combination PDT with N-acetyl cysteine (NAC). is widely used for treatment cSCC, and it involves visible light, molecular oxygen a photoactive compound (photosensitizer), leading death owing generation reactive species. TGFβ1 produced CAFs has been...