A5100418721- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Per- and polyfluoroalkyl substances research
- Rheumatoid Arthritis Research and Therapies
- Adipokines, Inflammation, and Metabolic Diseases
- Toxic Organic Pollutants Impact
- Sarcoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Bone Tumor Diagnosis and Treatments
- Spondyloarthritis Studies and Treatments
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Sirtuins and Resveratrol in Medicine
- Soft tissue tumor case studies
- Multiple Sclerosis Research Studies
- Effects and risks of endocrine disrupting chemicals
- Inflammatory mediators and NSAID effects
- Cytokine Signaling Pathways and Interactions
- Fatty Acid Research and Health
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
China Medical University
2013-2024
Peking University Shenzhen Hospital
2023
Sichuan University
2018-2023
First Affiliated Hospital Zhejiang University
2023
Southwest Medical University
2022
National Health and Family Planning Commission
2018-2022
Xi'an Jiaotong University
2018-2022
Linyi People's Hospital
2022
Yichang Central People's Hospital
2021
Wuhan University
2011-2020
The prevalence of osteoarthritis has been investigated in many countries and regions. Considering the wide differences ethnicity, socioeconomic status, environmental factors, lifestyle patterns, our study aimed to report knee (KOA) its associated factors rural areas Tianjin.This population-based cross-sectional was conducted between June August 2020. KOA diagnosed according 1995 American College Rheumatology criteria. Information on participants' age, years education, BMI, smoking drinking...
Circular RNAs (circRNAs) have recently been discovered as a novel type of endogenous non-coding RNA that may regulate gene expression in mammals. In the central nervous system (CNS), circRNAs are relevant to many neurological disorders such Alzheimer's disease (AD). this study, we attempted identify an aberrant circRNA, hsa_circ_0003391, which is significantly downregulated peripheral blood patients with AD, and explore relationship between hsa_circ_0003391 clinical manifestation AD. The had...
Dietary fatty acid (FA) content and type have different effects on obesity-associated osteoarthritis (OA), but the mechanisms underlying these differences are not fully understood. Inflammation activated by toll-like receptor 4 (TLR4)/nuclear factor- (NF-) κB signaling pyroptosis induced NLRP3/caspase-1/gasdermin D (GSDMD) pathway play important roles in OA development. Our aim this study was to observe of dietary FAs articular cartilage obese post-traumatic model mice chondrocytes...
Obesity has been associated with osteoarthritis (OA) due to increased mass and metabolic factors which are independent of the biomechanical contribution joint load. Resveratrol, a natural polyphenolic compound, exerts protective effects on OA through its anti-inflammatory property. However, mechanism resveratrol obesity-related is unclear. To investigate effect possible oral OA, we fed C57BL/6J mice high-fat diet (HFD) for 16 weeks establish model; then two doses (22.5 mg/kg 45 mg/kg) were...
Positive psychological constructs that can moderate or mediate the negative impact of disease activity on health-related quality life (HRQOL) in patients with rheumatoid arthritis (RA) have not been explored widely. This study aimed to assess associations activity, resilience HRQOL and moderating mediating roles among Chinese RA patients. A multi-center, cross-sectional was conducted inpatients northeast China. total 298 subjects completed Medical Outcomes Study 36-item Short-Form Health...
The effects of resveratrol on osteoarthritis (OA) pathogenesis have been demonstrated in vitro and animal models employing intra-articular injections. However, the potential for oral supplements to mediate protective OA not examined. Therefore, aim present study was investigate anti-OA mice fed a high-fat diet (HFD). C57BL/6J male were either standard or HFD, subset latter also received varying doses resveratrol. Twelve weeks later, all animals sacrificed knee joints evaluated with...
The natural polyphenolic compound, resveratrol, has been shown to exhibit anti-osteoarthritic activity. Therefore it is hypothesized that resveratrol may serve as a nutritional supplement counteract osteoarthritis (OA). However, the mechanisms responsible for these effects have not yet fully elucidated. aim of this study was determine whether biological against interleukin (IL)-1β‑induced inflammation in human articular chondrocytes involved both Toll-like receptor 4 (TLR4)/myeloid...
Aim of the study: Obesity leads to mild, chronic inflammation which is a primary risk factor for osteoarthritis (OA). Resveratrol exerts protective effect on OA through its anti-inflammatory properties, but precise mechanism remains unknown. The present study aimed investigate by resveratrol alleviates obesity-related OA, and whether it linked TLR4 PI3K/Akt signaling pathways.Materials methods: C57BL/6J male mice were fed high-fat diet (HFD) with or without treatment knee joints collected...
The X protein (HBx) of hepatitis B virus (HBV) is involved in the development hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) promotes growth liver cancer cells through altering S-adenosylmethionine homeostasis. Thus, we speculated that a link between HBx MAT2A may contribute to HCC development. In this study, effects on expression cell apoptosis were investigated, molecular mechanism by which regulate tumorigenesis was evaluated. Results from...
The polyphenol resveratrol (Rev) has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH). present study was designed investigate the action and potential mechanism Rev on PAH, focusing role SIRT1 (Silent Information Regulator 1) in apoptosis artery smooth muscle cells (PASMCs).PAH rats were established by exposure hypoxia for 21 days. SRT1720 (a selective activator) used reverse PAH gavaging rats. PASMCs confronted with 24 h or 48...
Vascular calcification (VC) is a complex, regulated process involved in many disease entities. So far, there are no treatments to reverse it. Exploring novel strategies prevent VC important and necessary for VC-related intervention.In this study, we evaluated whether MOTS-c, mitochondria-related 16-aa peptide, can reduce vitamin D3 nicotine-induced rats.Vitamin plus nicotine-treated rats were injected with MOTS-c at dose of 5 mg/kg once day 4 weeks. Blood pressure, heart rate, body weight...
Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship still poorly understood. Leptin, one most relevant factors secreted by adipose tissues, plays an important role in pathogenesis OA. Our aim was to investigate regulation and molecular mechanism leptin signaling pathway obesity‐related SD rats were fed with high‐fat diet (HFD) for 5, 15, 27 weeks. The levels serum increased from W5, while synovial fluid W15. histological evaluation showed that...
Early diagnosis of osteoarthritis (OA) is critical for effective cartilage repair. However, lack blood vessels in articular poses a barrier to contrast agent delivery and subsequent diagnostic imaging. To address this challenge, we proposed develop ultra-small superparamagnetic iron oxide nanoparticles (SPIONs, 4 nm) that can penetrate into the matrix cartilage, further modified with peptide ligand WYRGRL (particle size, 5.9 nm), which allows SPIONs bind type II collagen increase retention...
Teriflunomide is an oral disease-modifying therapy recently approved in several locations for relapsing forms of multiple sclerosis. To gain insight into the effects teriflunomide, immunocyte population changes were measured during progression experimental autoimmune encephalomyelitis Dark Agouti rats. Treatment with teriflunomide attenuated levels spinal cord-infiltrating T cells, natural killer macrophages, and neutrophils. also mitigated disease-induced immune cell populations blood...
Osteoarthritis (OA) is associated with chronic low-grade inflammation. Resveratrol exerts protective effects on OA through its anti-inflammatory property; however, the mechanism of resveratrol signaling pathways has not been fully elucidated yet. The aim present study was to investigate whether resveratrol-mediated PI3K/Akt expression linked TLR4/NF-κB pathway and role TLR4/Akt/FoxO1 axis in anti-osteoarthritic effect resveratrol.SW1353 cells stimulated by IL-1β (10 ng/mL) were cultured...
The mechanism underlying curcumin's protective effect on osteoarthritis (OA) has not been clarified. This study aimed to determine whether curcumin exerts a chondroprotective by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation autophagy the Akt/mTOR pathway targeting microRNA-34a (miR-34a).Male Sprague-Dawley rats were fed normal diet (ND) or high-fat (HFD) for 28 weeks. Five from each group selected randomly histological analysis OA characteristics. Rats HFD given single...
Abstract The abundance of inflammatory mediators in injured joint indicates innate immune reactions activated during temporomandibular osteoarthritis (TMJOA) progression. Toll‐like receptor 4 (TLR4) can mediate reaction. Herein, we aimed to investigate the expression profile and effect TLR4 cartilage subchondral bone discectomy‐induced TMJOA mice. NFκB p65 synovium patients was measured by immunohistochemistry, Western blotting RT‐PCR. H&E Masson staining were utilized assess damage A...