A5102973536- Primary Care and Health Outcomes
- Healthcare Policy and Management
- Tissue Engineering and Regenerative Medicine
- Pharmaceutical Practices and Patient Outcomes
- Cancer Cells and Metastasis
- Diverticular Disease and Complications
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Healthcare innovation and challenges
- Shoulder Injury and Treatment
- Problem and Project Based Learning
- Pelvic floor disorders treatments
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Maternal and fetal healthcare
- Gestational Trophoblastic Disease Studies
- COVID-19 Pandemic Impacts
- Appendicitis Diagnosis and Management
- Inhalation and Respiratory Drug Delivery
- Geophysics and Sensor Technology
- Religion, Spirituality, and Psychology
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Advanced Breast Cancer Therapies
University of Utah
2022-2025
Children's Hospital Colorado
2023
University of Colorado Denver
2021-2023
University of Colorado Cancer Center
2021
University of Colorado Anschutz Medical Campus
2020
University of Colorado Boulder
1985-2020
Harris Health System
2016-2020
Maryville University
2013
Background Cardiac fibroblasts (CFs) have the ability to sense stiffness changes and respond biochemical cues modulate their states as either quiescent or activated myofibroblasts. Given potential for secretion of bioactive molecules cardiac microenvironment, we sought determine how CF secretome with matrix this affects myocytes via paracrine signaling. Methods Results Myofibroblast activation was modulated in vitro by combining TGFβ1 (transforming growth factor β 1) treatment using...
Abstract Background Extracellular vesicles (EVs) are small membrane particles that contribute to cancer progression and metastases by transporting biologically significant proteins nucleic acids. They may also serve as biomarkers of various disease states or important therapeutic targets. Breast EVs have the potential change behavior other cells in their microenvironment. However, proteomic content isolated from young women’s breast patients mechanisms underlying influence on tumor cell not...
Texas is one of 8 states that have received a Medicaid 1115 Transformation Waiver in which federal supplemental payments are being used to incentivize delivery system reform. Under the Waiver's 5-year Delivery System Reform Incentive Payment (DSRIP) program, hospitals and other providers established regional health care partnerships, conducted needs assessments, developed implemented projects addressing local gaps service. The were selected from menus, supplied by Health Human Services...
Abstract Breast cancers that express hormonal receptors (HR) and HER2 display resistance to targeted therapy. Tumor-promotional signaling from the estrogen receptor (ER) pathways converges at cyclin D1 cyclin-dependent kinases (CDK) 4 6 complex, which drives cell-cycle progression development of therapeutic resistance. Therefore, we hypothesized co-targeting ER, HER2, CDK4/6 may result in improved tumoricidal activity suppress drug-resistant subclones arise on We tested triple combination...
Background and purpose: Kendall suggests testing the rotator cuff muscles in their maximally shortened position, since one-joint are thought to be strongest. We found little evidence support this concept. The purpose of study was determine if shoulder internal (IR) external (ER) strongest when placed length position. Methods: Fifty-three subjects participated. Glenohumeral joint rotation motion measured. Muscle strength then tested using a hand-held dynamometer four positions: (1) end-range...
The Texas Medicaid 1115 Transformation Waiver reforms the state's safety net systems by creating a Delivery System Reform Incentive Payment incentive pool for innovative healthcare delivery. supports design and implementation of transformative projects. As part requirements, regions created Learning Collaboratives to collaborate on project outcomes. This paper describes experience one region in adapting Institute Healthcare Improvement Breakthrough Series (IHI BTS) model, as framework their...
The Texas Medicaid Waiver, via the Delivery System Reform Incentive Payment (DSRIP) program, has provided a path for to achieve Triple Aim through its focus on defined population at project and system levels, financial payment policy based outcomes. Both iterations of DSRIP program (Waiver 1.0 2.0) have helped define populations, created regional collaboration that sets stage true integrator, incentives improving health, enhancing patient experience, controlling costs. flexible design menus...
Medically underserved patients experience significant barriers to affordable acute care. This brief report describes an innovative urban hospital-affiliated federally qualified health center urgent care clinic that successfully meets a medically population's need for accessible, appropriate, and
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