A5007416692- Heat shock proteins research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Wound Healing and Treatments
- ATP Synthase and ATPases Research
- Axon Guidance and Neuronal Signaling
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Urinary Bladder and Prostate Research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Nuclear Receptors and Signaling
- vaccines and immunoinformatics approaches
- RNA regulation and disease
- Hedgehog Signaling Pathway Studies
- Sphingolipid Metabolism and Signaling
- Bacterial biofilms and quorum sensing
University of Southern California
2012-2024
Shanghai Jiao Tong University
2019-2023
Kunming Medical University
2019-2023
Shanghai Chest Hospital
2022-2023
First Affiliated Hospital of Kunming Medical University
2019-2023
Huaian First People’s Hospital
2023
Nanjing University of Chinese Medicine
2022
Urology San Antonio
2020
University of Massachusetts Chan Medical School
2012-2018
Massachusetts Institute of Technology
2018
Understanding how the extracellular matrix impacts function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce laminin (LM) 511 promotes self-renewal and tumor initiation by engaging α6Bβ1 integrin activating Hippo transducer TAZ. Although TAZ important for CSCs, mechanism unknown. observed regulates transcription α5 subunit LM511 formation matrix. These data establish positive feedback loop involving contributes to stemness in cancer.
Although the α6β1 integrin has been implicated in function of breast and other cancer stem cells (CSCs), little is known about its regulation relationship to mechanisms involved genesis CSCs. We report that a CD44high/CD24low population, enriched for CSCs, comprised distinct epithelial mesenchymal populations differ expression two α6 cytoplasmic domain splice variants: α6A α6B. α6Bβ1 defines population necessary CSC function, cannot be executed by integrins. The generation tightly controlled...
We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and its expression in tumor cells induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses insulin-like growth factor-1 (IGF-IR) signaling, mechanism involves Bmi-1-mediated transcriptional repression IGF-IR. This has significant functional therapeutic implications were evaluated. IGF-IR positively correlates inversely NRP2 tumors. robust biomarker for...
Abstract Extracellular heat shock protein-90alpha (eHsp90α) plays an essential role in tumour invasion and metastasis. The plasma eHsp90α levels patients with various cancers correlate the stages of diseases. Nonetheless, mechanism action by tumour-secreted remained unclear. Here we show that accounts for approximately 1% total cellular Hsp90α is associated exosomes. CRISPR-cas9 knockout did not affect overall distribution quantity secreted exosomes, but it caused increased...
Alzheimer's disease (AD) is the leading cause of dementia globally, but effective treatment lacking. We aimed to explore lncRNA XIST role in AD and mechanisms involved effect changes on expression Aβ-degrading enzymes. The mouse model cell induced by Aβ were established. LncRNA XIST, IDE, NEP, Plasmin, ACE, EZH2 expressions distribution nucleus cytoplasm detected qRT-PCR. Inflammatory cytokines IL-6, IL-1β, TNFα, IL-8, Aβ42 levels ELISA. TUNEL was used measure brain tissue damage. Cell...
The growth factor VEGF induces a Rac1-TAZ–mediated positive feedback loop that sustains the proliferation of stem-like cells in breast cancer.
Long noncoding RNAs (lncRNAs) have been confirmed to be aberrantly expressed in various diseases including tumors. Recently, a new tumor-related lncRNA, lncRNA TRPM2 antisense RNA (TRPM2-AS), was shown involved many tumors, such as lung cancer and breast cancer. However, the expression role of TRPM2-AS development gastric (GC) not elucidated. In current study, we provided evidence that levels were increased both GC tissues cell lines. We also showed overexpression modulated by ELK1,...
Estrogen receptor β (ERβ) promotes the degradation of hypoxia inducible factor 1α (HIF-1α), which contributes to ability this hormone sustain differentiation epithelial and carcinoma cells. Although loss ERβ consequent HIF-1 activation occur in prostate cancer with profound consequences, mechanism by HIF-1α is unknown. We report that regulates ligand (3β-adiol)-dependent transcription prolyl hydroxylase 2 ( PHD2 ) also known as Egl nine homolog 1 EGLN1 ), a 2-oxoglutarate-dependent...
Tissue repair/wound healing, in which angiogenesis plays an important role, is a critical step many diseases including chronic wound, myocardial infarction, stroke, cancer, and inflammation. Recently, we were the first to report that orphan nuclear receptor TR3/Nur77 mediator of its associated microvessel permeability. Tumor growth induced by VEGF-A, histamine, serotonin are almost completely inhibited Nur77 knockout mice. However, it not known whether any roles wound healing. In these...
The role of ERβ in prostate cancer is unclear, although loss associated with aggressive disease. Given that mice deficient do not develop cancer, we hypothesized occurs as a consequence tumorigenesis caused by other oncogenic mechanisms and its necessary for tumorigenesis. In support this hypothesis, found targeted repression PTEN deletion important tumor formation. transcription repressed BMI-1, which induced This finding provides mechanism how expression regulated cancer. Repression...
Inflammatory response has an important role in the outcome of cerebral ischemia reperfusion injury (CIR). Biliverdin (BV) administration can relieve CIR rats, but mechanism remains unknown. The aim present study was to explore expressional network microRNA (miRNA)‑mRNA rats following BV administration. A rat middle artery occlusion model with treatment established. After neurobehavior evaluated by neurological severity scores (NSS), miRNA and mRNA profiles were analyzed microarray technology...
The epithelial-mesenchymal transition (EMT) is a fundamental process that underlies development and cancer. Although the EMT involves alterations in expression of specific integrins mediate stable adhesion to basement membrane, such as α6β4, mechanisms involved are poorly understood. Here, we report Snai1 inhibits β4 transcription by increasing repressive histone modification (trimethylation H3 at K27 [H3K27Me3]). Surprisingly, expressed localized nucleus epithelial cells, but it does not...
Abstract Non-small cell lung cancer (NSCLC), accounting for 85% of all cancer, is one the leading causes cancer-related death worldwide. Previously, we demonstrated that MPZL1 gene amplification promotes liver metastasis through activating Src/Cortactin pathway. However, clinical relevance and biological roles in are still unknown. Here, found expression upregulates human NSCLC, which partly due to copy number this gene. Next, observed high correlates with unfavorable prognosis NSCLC...
Abstract Increasing evidence indicates that lncRNAs play critical roles in various biological processes, but many have not been functionally characterized. Here, we report a novel radiation-inducible lncRNA, namely lnc-RI which is essential for cell survival and appropriate mitotic progression. Our data indicated knockdown of resulted spindle abnormalities arrest simultaneously with sharply decreased mRNA protein expression PLK1, key regulator mitosis. demonstrated PLK1 downstream mediator...