A5101401545- Advanced NMR Techniques and Applications
- Enzyme function and inhibition
- Solid-state spectroscopy and crystallography
- Enzyme Structure and Function
- Atomic and Subatomic Physics Research
- Computational Drug Discovery Methods
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Chemical Reactions and Mechanisms
- RNA and protein synthesis mechanisms
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cholinesterase and Neurodegenerative Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobin structure and function
- Inorganic Fluorides and Related Compounds
- Graphene and Nanomaterials Applications
- Lanthanide and Transition Metal Complexes
- 3D Printing in Biomedical Research
- Magnetism in coordination complexes
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Protein Tyrosine Phosphatases
- Erythrocyte Function and Pathophysiology
Advanced Imaging Research (United States)
2018-2022
The University of Texas Southwestern Medical Center
2018-2022
University of Houston
2016-2017
University of Southampton
1991
Novel polymyxin derivatives are often classified either as having direct activity against Gram-negative pathogens or compounds inactive in their own right, which through permeabilization of the outer membrane act potentiators other antibiotics. Here, we report systematic investigation influence lipophilicity on microbiological (including strains with reduced susceptibility to polymyxins), potentiation rifampicin, and vitro toxicity within a series next-generation nonapeptides. We demonstrate...
Tissue pH is tightly regulated in vivo, being a sensitive physiological biomarker. Advent of dissolution dynamic nuclear polarization (DNP) and its translation to humans stimulated development pH-sensitive agents. However, requirements DNP probes such as biocompatibility, signal sensitivity, spin-lattice relaxation time (T1) complicate vivo the Here, we developed 13C-labeled alanine derivative, [1-13C]-l-alanine ethyl ester, viable probe whose chemical shift range, demonstrated feasibility...
The rate of water exchange between the inner sphere a paramagnetic ion and bulk is an important parameter in determining magnitude chemical saturation transfer signal from CEST agents (paraCEST). This governed by various geometric, steric ligand field factors created macrocyclic ligands surrounding metal ion. Our previous on‐bead combinatorial studies di‐peptoid–europium(III)–1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA)–tetraamide complexes revealed that negatively charged...
Conventional one-bead one-compound (OBOC) library synthesis is typically used to identify molecules with therapeutic value. The design and of OBOC libraries that contain imaging or even potentially diagnostic capacities (e.g. theranostic agents) has been overlooked. development a therapeutically active molecule built-in component for certain target daunting task, structure-based rational might not be the best approach. We hypothesize develop combinatorial components fused together in each...
The TCA cycle is a central metabolic pathway for energy production and biosynthesis. A major control point of flux through the decarboxylation 2-ketoglutarate by enzyme dehydrogenase (2-KGDH). In this project, we developed 13C labeled derivatives to monitor 2-KGDH activity in vivo. NMR analysis liver extracts revealed that uniformly 2-ketogutarate, its cell permeable ester form, was rapidly taken up hydrolyzed underwent extensive metabolism produce glutamate, succinate, lactate other...
Abstract 77 Se is a spin , low sensitivity nucleus with natural abundance of 7.6 %. Although NMR very useful in the characterization selenium containing molecules including seleno‐proteins, detection challenging biological samples without enrichment. Therefore, goal this work was to establish whether signal could be enhanced liquid state by dissolution dynamic nuclear polarization (DNP) need The dominant spin‐lattice relaxation mechanism for via chemical shift anisotropy, which highly...
Selective radiolabelling of red blood cells via an enzyme-inhibitor approach represents a novel method in diagnostic nuclear medicine. Current problems pool labelling could be overcome by using selective sulphonamide inhibitors as carriers. Red cell carbonic anhydrase is identified ideal target enzyme for such approach. A brief review the presented together with screening series synthesised inhibitors. p-Iodobenzenesulphonamide, 4-[(4-iodophenyl)thio]benzenesul-phonamide and...