A5106974385- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemophilia Treatment and Research
- Pregnancy and preeclampsia studies
- Complement system in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Maternal and fetal healthcare
- Kruppel-like factors research
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
- S100 Proteins and Annexins
- Atrial Fibrillation Management and Outcomes
- Eosinophilic Disorders and Syndromes
- Reproductive Health and Contraception
- Renal Diseases and Glomerulopathies
- Blood properties and coagulation
- Cardiac electrophysiology and arrhythmias
- Cancer-related gene regulation
- Systemic Lupus Erythematosus Research
- Blood transfusion and management
- Vitamin K Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Neonatal Respiratory Health Research
Casa Sollievo della Sofferenza
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
University of Foggia
2005-2024
Weatherford College
2015
Thrombosis and Atherosclerosis Research Institute
2015
Inherited or acquired thrombophilias have been largely explored as a cause of pregnancy complications. However, pathogenesis obstetric complications, fetal loss and pregnancy-related hypertensive disorders is still partly unexplained. Recently, common haplotype (M2) within the annexin A5 (ANXA5) gene has described risk factor in recurrent losses (RFL). It demonstrated to reduce promoter activity ANXA5 luciferase reporter assays. Aim this study was investigate prevalence M2 three different...
In SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infected patients, hemostasis shows an uncontrolled activation, with a high D-dimer concentration.[1] [2] It has been also shown that the can promote endotheliitis,[3] and in turn, pulmonary endothelial damage fostering thrombogenesis.[4]
What evaluation and care is offered to women after unexplained recurrent pregnancy loss (RPL) or intra-uterine foetal death (IUFD) what are the reproductive outcomes?Women assessed for thrombophilia often treated with low-molecular weight heparin (LMWH) and/or low-dose aspirin (ASA).Randomized controlled trials (RCTs) on possible efficacy of heparins have been inconclusive due limited power detect a difference patient heterogeneity.Prospective multicentre cohort study performed in 12...
Obstetric hemorrhage is a life-threatening complication of pregnancy. Systematic collection data on transfusion practice during pregnancy and post-partum period are scarce, as well fetal or neonatal outcomes women transfused We examined the prevalence obstetric outcome pregnancies in hospitalized women. This retrospective cohort study collecting clinical laboratory from 2015 to 2017 three Italian Tertiary level Obstetrical Departments. Inclusion criteria were: 1) age >18 years; 2) antepartum...
In the atherosclerotic plaque, cyclooxygenase-2 (COX-2) catalyzes prostaglandin E formation, which acts as a pro-atherogenic factor. A polymorphism, G/C -765, within COX-2 promoter region modulates gene expression and risk of cerebrovascular disease. We have evaluated relation between -765 genotypes occurrence ischemia. polymorphism in 110 consecutive patients with documented history acute ischemic disease, age-matched sex-matched subjects without such history, general population (n = 324)...
Objective To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) pregnancies after assisted reproductive technologies (ART). Setting Thrombosis and Haemostasis Unit at I.R.C.C.S. ‘Casa Sollievo della Sofferenza’, S. Giovanni Rotondo. Participants A prospective 998 women advised to undergo ART was referred by local fertility clinics from April 2002 July 2011. Follow-up information obtained during check-up and/or phone interviews. In a who consecutively gave birth...
Summary Whether the administration of low-molecular-weight heparin (LMWH) during pregnancy is effective in preventing obstetric complications and pregnancy-related venous thromboembolism (VTE) women who are carriers factor V Leiden (FVL) and/or prothrombin variant G20210A (PTm) controversial. This observational study investigated possible efficacy pharmacological treatment with LMWH ± aspirin (ASA) outcomes 1,011 pregnancies 416 thrombophilia (FVL PTm). Most patients were chosen on basis...
Myeloproliferative diseases represent a major risk factor for Budd-Chiari syndrome. In 32 patients with syndrome, the JAK2 V617F mutation was detected, in heterozygous state, 11 individuals (34.4%; 95% confidence interval: 18.6-53.2). Eight (72.7%; 39.0-94.0) and six without (28.6%; 11.3-52.2) had diagnosis of myeloproliferative before or at occurrence venous thrombotic event. three carrying mutation, disease not detected. Determination may be useful to recognize syndrome subsequent...
Abstract Background Thrombotic microangiopathy has been invoked as one of the most important mechanisms damage in COVID-19 patients. Protease ADAMTS13 is a marker responsible for controlling von Willebrand multimers size. Von factor/ADAMTS13 ratio found impaired patients outside pregnancy. Methods We prospectively investigated 90 pregnant women admitted to two tertiary academic hospitals Italy with laboratory-confirmed diagnosis SARS-CoV-2 infection. Demographic, clinical information and...