A5023643447- Biosimilars and Bioanalytical Methods
- Biosensors and Analytical Detection
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Cell Image Analysis Techniques
- Glycosylation and Glycoproteins Research
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Carbohydrate Chemistry and Synthesis
- SARS-CoV-2 detection and testing
- Protein purification and stability
- Health Systems, Economic Evaluations, Quality of Life
Celerion (United Kingdom)
2024
Covance (United Kingdom)
2016-2021
Stevenage Bioscience Catalyst
2021
University Hospital Heidelberg
2010
Central Institute of Mental Health
2010
University College Dublin
2010
University of Cambridge
2010
National Institute for Bioprocessing Research and Training
2010
Heidelberg University
2010
Schizophrenia is a major neuropsychiatric disorder that affects 2% of the population worldwide. No biochemical diagnostic tests are available, and patients must undergo lengthy clinical evaluation periods before an accurate diagnosis can be given. Blood cerebrospinal fluid candidates for identification potential biomarkers this disease. We have identified several N-glycans distinguish first onset, unmedicated schizophrenia from healthy individuals. This report N-glycome low abundance serum...
Recombinant adeno-associated virus (AAV) vectors are the leading delivery vehicle used for
The 17
Background: The calcineurin inhibitor tacrolimus is a narrow therapeutic index medication, which requires drug monitoring to optimize dose on the basis of systemic exposure. MITRA microsampling offers minimally invasive approach for collection capillary blood samples from fingerprick as an alternative conventional venous sampling quantitation concentrations. Methods: A bioanalytical method in human whole collected tips was developed, using liquid–liquid extraction followed by liquid...
We aimed to establish novel, high-throughput LC-MS/MS strategies for quantification of monoclonal antibodies in human serum and examine the potential impact antidrug antibodies.We present two using a thermally stable immobilized trypsin. The first strategy uses whole digestion second introduces Protein G enrichment improve selectivity. anti-trastuzumab on methods was tested.Whole has been validated trastuzumab (LLOQ 0.25 µg/ml). 0.1 µg/ml), bevacizumab µg/ml) adalimumab have shown anti-drug...
Aim: For decades, the traditional approach for ligand-binding assays has been to generate two measurements from adjacent wells on plate. In recent years, scientists have investigated true benefit of this 'duplicate analysis' by looking back at previously generated bioanalytical data with conclusion that benefits are negligible. Materials & methods: We demonstrated a method development determine best number replicate an immunogenicity assay. used anti-pembrolizumab assay Gyrolab® challenge...
During the first half of 2021, and due to SARS-CoV-2 pandemic preventing in-person meetings, European Bioanalysis Forum organized four workshops as live interactive online meetings. The themes discussed at were carefully selected match cyberspace dynamics meeting format. workshop was a training day on challenges related immunogenicity. second one focused biomarkers continued important discussion integrating principles Context Use (CoU) in biomarker research. third dedicated technology, that...