A5027660554- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Myasthenia Gravis and Thymoma
- Neurological diseases and metabolism
- Cerebrovascular and genetic disorders
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Autoimmune Neurological Disorders and Treatments
- Dysphagia Assessment and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ophthalmology and Eye Disorders
- Trigeminal Neuralgia and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Parkinson's Disease and Spinal Disorders
- Cerebral Palsy and Movement Disorders
- Spinal Cord Injury Research
- Psychosomatic Disorders and Their Treatments
- Genetic Neurodegenerative Diseases
- Actinomycetales infections and treatment
Praxis
2024
Spital Uster
2022-2024
Spital Linth
2017-2023
University of Zurich
2021-2022
Zug Cantonal Hospital
2020
Kantonsspital Winterthur
2010-2019
Klinik für Schlafmedizin
2018
University of St. Gallen
2012-2016
Kantonsspital St. Gallen
2010-2015
Amyotrophic Lateral Sclerosis Association
2012
Background Motor Unit Number Index (MUNIX) is a novel neurophysiological measure that provides an index of the number functional lower motor neurons in given muscle. So far its performance across centres patients with amyotrophic lateral sclerosis (ALS) has not been investigated. Objective To perform longitudinal MUNIX recordings set muscles multicentre setting order to evaluate value as marker disease progression. Methods Three applied 51 ALS over 15 months. Six different (abductor pollicis...
Percutaneous endoscopic gastrostomy (PEG) tube placement in amyotrophic lateral sclerosis (ALS) patients with impaired respiratory function is associated an increased risk of peri-procedural and post-interventional complications. It was the aim study to analyze peri- complications survival after PEG under noninvasive ventilation (NIV) ALS various degrees impairment.Twenty-six subjects were included this retrospective case study. Prior placement, training ventilatory support via oronasal mask...
BACKGROUND: One problem in the mobilization of patients with neurological diseases, such as spinal cord injury, is circulatory collapse that occurs while changing from supine to vertical position because missing venous pump due paralyzed leg muscles. Therefore, a tilt table integrated stepping device (tilt stepper) was developed, which allows passive movements for performing locomotion training an early state rehabilitation. The aim this pilot study investigate if and cycling legs during...
<b><i>Background:</i></b> The forced vital capacity (FVC) is an established measure in amyotrophic lateral sclerosis (ALS) clinical trials. Recently the sniff nasal inspiratory pressure (SNIP) test has been increasingly used as a respiratory measure. <b><i>Objectives:</i></b> It was aim of this study to assess feasibility SNIP outcome phase III trial with lead-in design. <b><i>Methods:</i></b> Twenty patients were...
Diffusion tensor spectroscopy (DTS) combines features of magnetic resonance and diffusion imaging permits evaluating cell-type specific properties microstructure by probing the intracellular metabolites. This exploratory study investigates for first time microstructural changes in neuronal glial compartments brain patients with amyotrophic lateral sclerosis (ALS) using DTS. To this end, metabolite tNAA (N-acetylaspartate + N-acetylaspartylglutamate) predominantly metabolites tCr (creatine...
Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities presumed vascular origin (WMH) compare APTw signal intensity healthy (healthy WM) with MSL WHM. Materials Methods: A total 27 patients (16 female, 11 males, mean age 39.6 years) sclerosis, 35 (17 females, 18 66.6 small vessel disease (SVD) 20 young volunteers (9 29 were included in MSL,...
<h3>BACKGROUND AND PURPOSE:</h3> In postmortem studies, subclinical optic nerve demyelination is very common in patients with MS but radiologic demonstration difficult and mainly based on STIR T2WI. Our aim was to evaluate 3D double inversion recovery MR imaging for the detection of demyelinating lesions within segments. <h3>MATERIALS METHODS:</h3> The signal intensities 4 different segments (ie, retrobulbar, canalicular, prechiasmatic, chiasm) were evaluated 95 without visual symptoms past...
<b><i>Background:</i></b> Recently, mutations in the <i>TARDBP</i> gene encoding TAR DNA-binding protein 43 (TDP-43) have been identified<b> </b>in some familial amyotrophic lateral sclerosis (ALS) and sporadic ALS patients. The phenotype frequency of mutation carriers reportedly varies greatly among European populations. <b><i>Objective:</i></b> To define phenotypic spectrum their a Swiss population....
Radiculopathy can be caused by nerve root irritation and compression at the level of lateral recess or intervertebral foramen. T2-weighted (T2w) MRI is considered essential to evaluate its course, starting through foramen extraforaminal space. With introduction novel acceleration techniques such as compressed SENSE, standard-resolution 2D T2w turbo spin echo (TSE) sequences with a slice-thickness 3-4 mm replaced high-resolution isotropic 3D TSE sub-millimeter resolution without prolonging...
Ultrasound has become a reliable method to detect fasciculations. There is disagreement as whether fasciculations above the knee should raise suspicion of disorder even if there are no other signs lower motor neuron abnormality.Using ultrasonography, 3 arm and leg muscles were investigated for 120 s, 45 min after 90-min handball training or 5,000 meter run in group 25 men women players 7 who amateur runners.All athletes had knee. upper limb runner group. In 21 18 between 1 17 2 detected. The...
Progressive aphasia as the presenting symptom in a patient with amyotrophic lateral sclerosis novel mutation OPTN gene
PurposeTo investigate the diagnostic yield of low to ultra-high b-values for differentiation benign from malignant vertebral fractures using a state-of-the-art single-shot zonal-oblique-multislice spin-echo echo-planar diffusion-weighted imaging sequence (SShot ZOOM SE-EPI DWI).Materials and Methods66 patients (34 malignant, 32 benign) were examined on 1.5 T MR scanners. ADC maps generated 0,400; 0,1000 0,2000s/mm2. ROIs placed into fracture interest trace images adjacent normal bodies...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with involvement of the upper and lower motor neurons. Since loss fine skills one earliest signs ALS, hypothesis was tested if nine hole PEG test (NHPT) transcranial magnet stimulation (TMS) resting-motor threshold (RMT) could be useful in monitoring progression.We examined 28 ALS patients 27 age-matched healthy controls. controls underwent peg TMS RMT. Measurements were repeated after three six months.At baseline, median...
Cerebral nocardiosis abscess is a very rare entity in an immunocompetent patient. In this case report multiparametric and multimodality MR imaging characteristics of pyogenic brain caused by Nocardia Farcinica are discussed with specific focus on amide proton transfer weighted as modern non-invasive, molecular method which detects endogenous mobile protein peptide concentration tissue pH changes pathologic lesions. The reviewed respect to possible differential diagnoses, especially malignant tumorous
"The role of the SenseWear device and ghrelin for metabolism in amyotrophic lateral sclerosis." Amyotrophic Lateral Sclerosis Frontotemporal Degeneration, 17(3-4), pp. 295–296
Isolated traumatic oculomotor nerve palsy without internal ophthalmoplegia is a rare condition after closed head trauma. The strain leads to intraneural edema with swelling on T2-weighted magnetic resonance (MR) images and disruption of the blood peripheral barrier contrast enhancement T1-weighted MR images. In this patient, susceptibility-weighted imaging allowed direct visualization hemorrhage suspected diffuse neuronal axonal injury.
Diffusion restriction is the morphologic hallmark of acute ischemic infarcts and excitotoxic brain injury in various cerebral pathologies. visible as hyperintensity on DWI hypointensity ADC maps. Due to vicinity multiple anatomic structures stem hippocampus, very small lesions with diffusion may result severe clinical symptomatology, but these easily go undetected standard due insufficient spatial resolution, T2* blurring, image artifacts caused by susceptibility-related distortions....