This study is aimed at the development of a safe radioprotective formulation to minimize human sufferings during accidental nuclear exposures. In current study, combination three active principles, namely podophyllotoxin, podophyllotoxin beta-D-glucoside, and rutin (G-002M), isolated from Podophyllum hexandrum rhizomes, has been evaluated for its potential mode action. Total body protection studies have demonstrated that single prophylactic dose G-002M delivered more than 85% survival in...

Diallyl sulfide (DAS) is a garlic-derived organosulfur compound known for its chemotherapeutic properties, as strong food additive and potential radiomitigator. Despite therapeutic potentials, the apparent lack of toxicity data hinders clinical applications. The present study investigated pre-clinical DAS to identify maximum tolerable lethal doses understand underlying mechanisms at toxic doses. was administered intraperitoneally C57BL/6 mice range concentrations (160, 1280, 1600, 1920...

Catharanthus roseus (L.) G. Don produces a number of biologically active terpenoid indole alkaloids via complex alkaloid biosynthetic pathway. The final dimerization step this pathway, leading to the synthesis dimeric alkaloid, vinblastine, was demonstrated be catalyzed by basic peroxidase. However, reports gene encoding enzyme are scarce for C. roseus. We report here first time cloning, characterization and localization novel peroxidase, CrPrx, from A 394 bp partial peroxidase cDNA ( CrInt1...

Radiation-induced gastrointestinal injury (RIGI) is a serious side effect of abdominal and pelvic radiotherapy, which often limits the treatment gynaecological cancers. RIGI also observed during accidental radiological or nuclear scenarios with no approved agents available till date to prevent mitigate in humans. Trichostatin A (TSA), an epigenetic modulator, has been currently clinical trials for cancer well known its antibiotic antifungal properties.In this study, partial body (abdominal)...

The detrimental effect of nuclear accidents due to localized or whole body radiation exposure results in severe cellular damage. current study was carried out evaluate radiation-mediated variability blood components metal scrap workers exposed accidently cobalt-60 source. Blood samples collected initially from five hospitalized patients, coded P1-P5, were processed for total leukocyte counts (TLC), platelet (PLT) counts, haemoglobin, estimation DNA double strand breaks by measuring...

The study was planned to evaluate modulatory effect of aqueous extract Piper betle leaf (PBL) on ionizing radiation mediated oxidative stress leading normal tissues damage during radiotherapy and other exposures. total polyphenols flavonoids known as free radical scavenger (chelators) were measured in the extract. To ascertain antioxidant potential PBL we studied scavenging, metal chelation, reducing power, lipid peroxidation inhibition ferric properties (FRAP) using vitro assays. Mice...

Intestinal injury is inevitable during exposure to high radiation doses and a common side effect observed abdominal/pelvic radiotherapy. Yet, no countermeasures are available for gastrointestine (GI) management. The aim of this study determine the effects podophyllotoxin rutin in combination (G-003M) on ionising induced GI injury. We prophylactically administered G-003M C57BL/6J mice exposed 9 Gy total body (TBI) assessed morphological changes, loss absorption, fluid retention, biochemical...

Radiation-induced hematopoietic dysfunction is one of the most common problems during unplanned radiation exposures and also in cancer patients receiving radiotherapy. Management system necessary to promote survival against radiation. The present study was undertaken demonstrate protective potential Quercetin 3 rutinoside (Q-3-R), gamma radiation-induced injuries. C57BL/6 male mice exposed either or pretreated with Q-3-R (10 mg/kg body weight) were checked for protection using hematotoxicity...

Irradiation causes extensive alteration in the cellular homeostasis leading to severe organ damage and dysfunction. The lack of understanding mechanism conferring radioprotection is often considered a major limitation development agents that suppress damaging effects radiation. In this study, we demonstrate Quercetin 3-O-rutinoside (Q-3-R), flavonoid, can significantly protect gastrointestine against gamma radiation induced damage. Q-3-R (10 mg/kg body weight) treated C57BL/6 mice were...

Radiation-induced exchange aberrations are thought to arise as a consequence of misrejoining free ends DNA double strand breaks (dsbs). In quiescent mammalian cells this process is prevalently taken up by the non-homologous end joining (NHEJ) process. order investigate role glutathione (GSH) in dsb rejoining, interaction lesions induced bleomycin (Blem) and radiation was studied since caused both have similar apparent rapid rates repair. Endogenous GSH depleted buthionine sulfoximine (BSO)...

view Abstract Citations (24) References (37) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Ionization States of the Anomalous Cosmic Rays Singh, R. K. ; Mitra, Banashree Durgaprasad, N. Biswas, S. Vahia, M. Yadav, J. Dutta, A. Goswami, states individual N, O, and Ne ions in low-energy (10-30 MeV/n) anomalous cosmic rays (ACR) were detected Anuradha experiment performed on Space Shuttle Spacelab-3 mission during April-May 1985. The instrumentation made it...

Allium sativum (garlic) is used as food additives and medicines. Its health benefits are well known, which mainly contributed by the active organosulfur compounds present in it. Though garlic widely used, but limited known about preclinical acute toxicity of its mice. The study aimed at evaluation diallyl sulfide (DAS) C57BL/6 mice following oral administration range concentrations (40 mg/kg, 400 800 mg/kg 1600 mg/kg). Survival, hematological, organ coefficients, histopathology studies were...