A5052295555- Autopsy Techniques and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Disaster Response and Management
- Superconducting Materials and Applications
- Forensic Anthropology and Bioarchaeology Studies
- Monoclonal and Polyclonal Antibodies Research
- Forensic and Genetic Research
- Spacecraft and Cryogenic Technologies
- Particle accelerators and beam dynamics
- Trauma and Emergency Care Studies
- European and International Law Studies
- T-cell and B-cell Immunology
- Education, Healthcare and Sociology Research
- Immune Cell Function and Interaction
- Spine and Intervertebral Disc Pathology
- Immune Response and Inflammation
- Forensic Entomology and Diptera Studies
- Medical Malpractice and Liability Issues
- Spinal Fractures and Fixation Techniques
- Immunotherapy and Immune Responses
- Disaster Management and Resilience
- Molecular Biology Techniques and Applications
- Injury Epidemiology and Prevention
- Glycosylation and Glycoproteins Research
- Electromagnetic Launch and Propulsion Technology
University of Southern Denmark
2001-2024
Facility for Rare Isotope Beams
2024
Thomas Jefferson National Accelerator Facility
2006-2015
Bispebjerg Hospital
2015
Institute of Forensic Science
1999-2013
United States Army Reserve
2003
Aarhus Municipality
1994-1997
Aarhus University Hospital
1994-1996
Aarhus University
1993
Aalborg University
1993
The effect of prostaglandins and cyclic 3',5'-adenosine monophosphate (cAMP) on expression human interleukin 1 (IL 1) activity was investigated in the promonocytic tumor cell line U937 peripheral blood monocytes. After vitro stimulation by bacteriotoxins, monocytes express IL activity, as measured thymocyte costimulation assay. Although high doses bacteriotoxins impaired 1, this reversed indomethacin. When stimulated were cultured with exogenous prostaglandins, including PGE2 PGI2,...
Abstract We investigated effects of corticosteroids on interleukin 1 (IL-1) production in monocyte-like tumor cell line, U937. Release IL-1 activity by bacterial toxin-stimulated cells was completely blocked 10 nM dexamethasone (Dex). examined the question whether suppress blocking transcription mRNA, or synthesis at a post-transcriptional step. Northern blot hybridization analysis indicated that Dex, nM, accumulation beta-encoding mRNA U937 cells. Dex-mediated inhibition release appeared to...
A monoclonal antibody (HC 2.1) directed against the separated heavy chain of HLA-DR has been prepared. By binding HC 2.1 to polysomes from human B lymphoblastoid cells followed by use a protein A-Sepharose column as an immunoadsorbent, we have purified mRNA coding for nearly homogeneity. The immunopurified used prepare labeled cDNA with which probe libraries. Double-stranded was also made and cloned directly into pBR322. Two clones, one each above procedures, positively selected DR message...
We have investigated beta 2-microglobulin (beta 2M) synthesis and release by blood leukocytes isolated mononuclear phagocytes. Recent interest in 2M has developed since the discovery that this protein forms amyloid fibrils patients undergoing long-term, chronic hemodialysis these greatly elevated levels of monomeric their circulation. Since hemodialysis-related factors increase production are unknown, we evaluated freshly prepared monocyte-derived macrophages under a variety conditions....
Serum components inhibit DNA polymerase, thereby obviating direct detection of serum viral sequences by the polymerase chain reaction (PCR). This has necessitated extraction nucleic acid from sera before performing PCR and resulted in loss sensitivity. By adsorbing virus to a solid surface (microcentrifuge tubes or antibody coated microparticles) followed proteinase K digestion, as little three viruses per 200 microliters may be directly detected without extraction. The sensitivity is...
Interleukin 1 (IL 1) produced by a human tumor cell line was purified to homogeneity three-step chromatographic method and tested in various assays for multiple biologic properties. The IL stimulated the proliferative response of D10.G4.1 line, mouse indicator T cell; caused release prostaglandin E2 prostacyclin from cultured foreskin fibroblasts primary umbilical vein endothelial cells; elicited characteristic endogenous pyrogen fever rabbits. To stimulate production, histiocytic lymphoma...
The thermal stability of lipid-free rhodopsin in solutions a homologous series alkyltrimethylammonium bromide detergents and one nonionic detergent, dodecyl-β-maltoside, has been studied as function detergent concentration. Rhodopsin increases with increasing chain length within the ionic detergents, for lengths greater than 10 carbon atoms concentration up to “critical” that depends on length. Stability also detergent. These results may be rationalized terms dependence micelle packing...
The modified International Knee Documentation Committee Subjective Form (Pedi-IKDC) is a widely used patient-reported tool ranging on scale from 0 to 100. We aimed translate Pedi-IKDC into Danish and assess its reproducibility responsiveness in children with knee disorders. translation complied the international guidelines. Reproducibility was assessed 53 (15 years) responding at baseline after 3-14 days. For analysis of responsiveness, 94 responded again 3 months. Test-retest reliability...
ABSTRACT Heritable disorders that feature high bone mass (HBM) are rare. The etiology is typically a mutation(s) within gene regulates the differentiation and function of osteoblasts (OBs) or osteoclasts (OCs). Nevertheless, molecular basis unknown for approximately one-fifth such entities. NF-κB signaling key regulator remodeling acts by enhancing OC survival while impairing OB maturation function. transcription complex comprises five subunits. In mice, deletion p50 p52 subunits together...
The planned approach to have a turnkey helium refrigeration system for the MSU-FRIB accelerator system, encompassing design, fabrication, installation and commissioning of 4.5-K refrigerator cold box(es), compression warm gas management, oil removal utility/ancillary systems, was found be cost prohibitive. Following JLab's suggestion, management made formal request evaluate applicability recently designed 12GeV JLab cryogenic this application. following paper will outline findings FRIB system.
Abstract Antibodies which react with products encoded by the human DR locus precipitate a biomolecular membrane glycoprotein complex m.w. of 29,000 and 34,000 daltons. Such antibodies are directed against HLA-DR Ia-like antigens found on B cells monocytes have been shown previously to inhibit variety in vitro cellular humoral immune reactions. We compared effects such two assays immunity: antigen-specific proliferation polyclonal immunoglobulin production. Intact IgG fractions rabbit...
Abstract Immersion Pulmonary Edema ( IPE ) reduces the transport of gases over respiratory membrane due to edema in interstitium and zones. has previously been described both swimmers divers, with a few known fatal cases. We have reviewed 42 SCUBA snorkeling‐related drowning deaths, through thorough analysis each case, including diving physiology forensic pathology, we present as differential diagnosis four Our findings propose that; absence watery content stomach conducting airways, liquid...
We have investigated the regulation of β2-microglobulin (β2-M) synthesis by monocytes. Recent interest in β2-M has developed since discovery that this protein forms amyloid fibrils patients undergoing long-term, chronic hemodialysis. The amyloid-osis is linked to greatly elevated levels monomeric their circulation. Since factors govern release from plasma membranes are not known, we endeavored evaluate during monocyte activation. Utilizing a human monocyte-like cell line, U937, studied...