A5088599670- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Lung Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Bariatric Surgery and Outcomes
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Clinical Nutrition and Gastroenterology
- Eosinophilic Esophagitis
- Medical Device Sterilization and Disinfection
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
Hospital Clínico San Carlos
2016-2025
Hospital Universitario Dexeus
2020-2023
Hospital Quirón Teknon
2020-2023
Hospital Universitario 12 De Octubre
2023
Hospital Ruber Internacional
2023
Hospital Son Llatzer
2023
Sri Aurobindo Institute of Medical Sciences
2023
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2020
Sociedad Española de Patología Digestiva
2019
Sociedad Española de Endoscopia Digestiva
2019
A novel large-diameter, lumen-apposing, self-expanding metal stent with bilateral flanges was recently developed for endoscopic ultrasound (EUS)-guided transmural drainage of symptomatic pancreatic fluid collections (PFCs). The aim this study to evaluate the efficacy and safety in a large cohort.Patients PFC undergoing EUS-guided were prospectively enrolled multicenter cohort study.There 61 patients: 46 patients (75 %) walled-off necrosis (WON) 15 (25 pseudocyst. Stent placement technically...
Inflammatory myofibroblastic tumor (IMT) of the urinary tract, also termed postoperative spindle cell nodule, inflammatory pseudotumor, and pseudosarcomatous fibromyxoid tumor, is rare in past was believed to reflect diverse entities. We reviewed a series 46 IMTs arising ureter, bladder, prostate, derived primarily from large consultation practice. There were 30 male 16 females aged 3 89 years (mean 53.6). Lesions 1.2 12 cm 4.2). history recent prior instrumentation 8 cases. Morphology...
BackgroundComputer-aided detection (CADe) systems could assist endoscopists in detecting early neoplasia Barrett's oesophagus, which be difficult to detect endoscopic images. The aim of this study was develop, test, and benchmark a CADe system for oesophagus.MethodsThe first pretrained with ImageNet followed by domain-specific pretraining GastroNet. We trained the on dataset 14 046 images (2506 patients) confirmed oesophagus non-dysplastic from 15 centres. Neoplasia delineated experts all...
Monoclonal antibody (MAb) B72.3 has been previously shown, by in vitro assays, to have a high degree of specificity for carcinomas the colon, ovary and breast versus normal adult tissues. IgG was labelled with 131I injected i.v. into 20 patients known or suspected colorectal cancer. All subsequently underwent surgical exploration, tumor selected tissues removed staging purposes. The selective localization 131I-MAb demonstrated biodistribution studies which % ID/g each compared that tissues,...
RNA biomarkers discovered by RT-PCR-based gene expression profiling of archival formalin-fixed paraffin-embedded (FFPE) tissue form the basis for widely used clinical diagnostic tests; however, RT-PCR is practically constrained in number transcripts that can be interrogated. We have developed and optimized RNA-Seq library chemistry as well bioinformatics biostatistical methods whole transcriptome from FFPE tissue. The accommodates low inputs sample multiplexing. These both enable rediscovery...
Radiofrequency ablation (RFA) is safe and effective for the eradication of neoplastic Barrett's esophagus; however, occasionally there minimal regression after initial circumferential balloon-based RFA (c-RFA). This study aimed to identify predictive factors a poor response 3 months c-RFA, relate percentage at final treatment outcome.We included consecutive patients from 14 centers who underwent c-RFA high grade dysplasia worst. Patient characteristics were registered prospectively. "Poor...
Abstract Background and aims Seattle protocol biopsies for Barrett's Esophagus (BE) surveillance are labour intensive with low compliance. Dysplasia detection rates vary, leading to missed lesions. This can potentially be offset computer aided detection. We have developed convolutional neural networks (CNNs) identify areas of dysplasia where target biopsy. Methods 119 Videos were collected in high‐definition white light optical chromoendoscopy i‐scan (Pentax Hoya, Japan) imaging patients...
The clinicopathologic, immunohistochemical, and flow cytometric characteristics of 34 cases mammary carcinoma with metaplasia were compared those 20 pure sarcoma the breast. All latter tumors showed pattern malignant fibrous histiocytoma. There mesenchymal metaplasia, 7 mixed epithelial (squamous) (four ductal/squamous three squamous cell carcinomas). No patient had lymph node metastases develop; all nodal found in patients who although one case carcinomatous component was seen only within a...
Obesity is a multifactorial, chronic, progressive and recurrent disease considered public health issue worldwide an important determinant of disability death. In Spain, its current prevalence in the adult population about 24% estimated 2035 37%. increases probability several diseases linked to higher mortality such as diabetes, cardiovascular disease, hyperlipidemia, arterial hypertension, non-alcoholic fatty liver types cancer, or obstructive sleep apnea. On other hand, although incidence...
Characterization of visible abnormalities in patients with Barrett's esophagus (BE) can be challenging, especially for inexperienced endoscopists. This results suboptimal diagnostic accuracy and poor interobserver agreement. Computer-aided diagnosis (CADx) systems may assist We aimed to develop, validate, benchmark a CADx system BE neoplasia.
Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in medical literature. There persisting controversy regarding pathogenesis and biology of these lesions. We report well-studied well-characterized case benign lung. The patient was 72-year-old woman with an enlarged uterus contained several leiomyomas usual histology. Areas fibrosis, hyalinization, edema, focal infarction together small foci mildly increased cellularity...
Twenty-nine patients with clinical stage Tl-2, NO, MO prostate carcinoma were treated by retropubic radical prostatectomy. Diagnosis was made fine-needle aspiration biopsy from six to eight separate sectors of the prostate. At time biopsy, diagrams palpated organ drawn, depicting location lesion and site each biopsy. Without examiners' knowledge cytologic data, extirpated glands examined whole histologic sections, carcinomas scored according method Gleason. The extent all atypical malignant...
BACKGROUND Vascular enumeration using antibodies to Factor VIII has been reported be an independent prognostic indicator of invasive breast carcinoma. METHODS To eliminate potential subjectivity in distinguishing between individual vessels, especially areas tangled capillaries, total endothelial area (EA) was assessed a Samba 4000 image analyzer. One hundred seventy-eight carcinomas (Stage 1 and 2, mean follow-up: 71 months) were immunostained for the presence CD34, human hematopoietic...