A5101624720- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Pharmaceutical studies and practices
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Adolescent and Pediatric Healthcare
- Child and Adolescent Health
- Osteomyelitis and Bone Disorders Research
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Orthopedic Infections and Treatments
- Bone health and treatments
- Blood disorders and treatments
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Medical Imaging and Pathology Studies
Children's Hospital Zagreb
2007-2024
University of Osijek
2018-2024
University of Zagreb
2011-2021
University Hospital Centre Zagreb
2012-2021
University of Dubrovnik
2021
Boston Children's Hospital
2010-2012
Palmetto Hematology Oncology
2010
Background: Among malignant diseases which develop during childhood, hematological cancers, such as leukemias and lymphomas, are the most common. Outcomes have greatly improved due to refinement of multiagent chemotherapy regimens that include enhanced asparaginase therapy. In this study, we aimed evaluate our experiences related analytical clinical significance determining l-Asparaginase activity. Methods: Since 2016, Laboratory Children’s Hospital Zagreb has routinely measured activity...
To assess the clinical-biological characteristics and outcomes of Croatian pediatric patients with acute lymphoblastic leukemia (ALL). A secondary aim was to evaluate predictive value pretreatment leukemia-associated immunophenotypes (LAIPs) for poor early response induction therapy defined as ≥10% day 15 bone marrow flow cytometry minimal residual disease (FCM-MRD). This retrospective cohort study reviewed medical data 393 consecutive ALL diagnosed treated from February 2003 April 2017 at...
The mast-cell sarcoma of a bone is described here for the first time. tumour presented in 4-year-old boy, with pain, oedema and deformation his right lower leg. Radiological findings revealed destructive tumourous mass. Histopathological examination showed to be composed large, atypical cells, hyperchromatic oval polygonal nuclei. cytoplasm around them was eosinophilic many basophilic toluidine-blue-positive granules. These mast cells were positive chloroacetate esterase, c-kit, tryptase...
The collection of peripheral blood stem cells, although now a routine procedure, is still challenge in low body weight children because specific technical and clinical issues. For paediatric patients it crucial to obtain an adequate number CD34+ cells with the minimum procedures: this can be done using large volume leukapheresis (LVL).We analysed efficacy safety 54 autologous LVL performed 50 (33 [66%] males 17 [34%] females), median age 2 years (range, 1-5) 12 kg 6-15). procedures were COBE...
Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with tumour and plays an important role in determining the response to treatment general, clinical data are still insufficient, more evaluations needed draw conclusions. The aim of this study was evaluate vascular endothelial growth factor (VEGF) expression neuroblastoma, determine whether it other prognostic factors and/or therapeutic response, assess should VEGF be...
Abstract We report a 2‐year‐old female with subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma positive EWSR1 rearrangement and EWS/FLI1 transcript. After finding lymphoblasts in peripheral blood, the diagnosis of acute lymphoblastic leukemia established. This necessitated further analysis tumor. The tissue for immature B‐cell markers an immunoglobulin heavy chain gene rearrangement, which confirmed final common type bulk extramedullary disease. patient treated...
Inflammatory bowel disease (IBD) is a well-recognized risk factor for thrombotic events in adults but data on children are scarce.In the great majority of adult patients, usually deep vein thrombosis and pulmonary embolism.Other sites such as jugular veins extremely rare.We present case Lemierre syndrome an adolescent girl with active ulcerative colitis discuss possible factors.This first reported severe thrombus extension to cranial patient colitis.Early recognition patients who rapidly...
Nutritional status is recognized as an independent and modifiable risk factor of outcome in stem cell transplant. Our research aim was to evaluate the impact body mass index (BMI) serum albumin on prevalence adverse events survival autologous transplant children. A retrospective study conducted transplants performed between 2006 2017 Children's Hospital Zagreb, Croatia. assessed at times diagnosis, procedure, discharge using BMI (underweight, normal, obese) (grades 1–4). Adverse (fever,...
Aim: As the results of pharmacogenetic studies are increasingly translated into clinical practice, ultimate goal personalising treatment for children with cancer seems achievable in future. Our survey aimed to establish what extent pharmacogenetics has already been utilised everyday work.Methods: A retrospective on testing treated malignancies at Department Oncology and Haematology, Children’s Hospital Zagreb, from 2021 2023 was carried out.Results: Pharmacogenetic performed 17.2% 180 (53.3%...
Ista tumorska bolest kod različitih bolesnika može imati različitu prognozu, odnosno dužinu preživljenja. S ciljem individualizacije terapije i poboljšanja liječenja pedijatrijskih malignih tumora, intenzitet vrsta iste tumorske bolesti razičitih mo?e biti različita. Razlike u liječenju određene su stupnjem rizika, prognostičkim čimbenicima rizika. Prognostički čimbenici rizika utječu na ishod preživljenje.
Despite thorough medical assessment, diagnosis of inherited bone marrow failure syndrome (IBMFS) is often significantly delayed. Genomic investigations have been more used to facilitate correct and guide management in unexplained childhood cytopenias. We present two cases unrelated adolescent girls with bicytopenia, unremarkable history normal physical features who were diagnosed nonclassical IBMFS ( ERCC6L2) using genetic evaluation. ERCC6L2-associated disease has so far frequently related...
In this study we investigated the presence of antisperm antibodies in sera neonatal and young calves up to age 120 days by indirect immunofluorescence assay (IIP) sperm-agglutination method. By IIP assay, anil IgG ants IgM were detected. calves, before colostrum ingestion, no anti-sperm detected due physiological agammaglobulinemia. Titer obtained values two day old older different for native sperm cells previously suspended TRIS egg yolk extender or Biociphos plus (IMV, France) indicating...