A5042040640- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Inorganic Chemistry and Materials
- Magnetism in coordination complexes
- Coordination Chemistry and Organometallics
- Adenosine and Purinergic Signaling
- Nuclear Materials and Properties
- Chemical Reactions and Mechanisms
- Crystallography and molecular interactions
- Inorganic and Organometallic Chemistry
- Supramolecular Chemistry and Complexes
- CO2 Reduction Techniques and Catalysts
- Radiopharmaceutical Chemistry and Applications
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Chemical Reactions and Isotopes
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and Properties of Aromatic Compounds
- Carbon dioxide utilization in catalysis
- Synthesis and Catalytic Reactions
- Ammonia Synthesis and Nitrogen Reduction
- Fluorine in Organic Chemistry
University of Sussex
2022-2025
École Polytechnique Fédérale de Lausanne
2018-2025
Institut de Chimie
2019
Charles Humbert 8
2019
The concept of oxidation state plays a fundamentally important role in defining the chemistry elements. In f block periodic table, well-known states compounds lanthanides include 0, +2, +3 and +4, for actinides range from +7 to +2. Oxidation +1 is conspicuous by its absence f-block Here we show that uranium(II) metallocene [U(η5-C5iPr5)2] uranium(III) [IU(η5-C5iPr5)2] can be reduced potassium graphite presence 2.2.2-cryptand uranium(I) [U(η5-C5iPr5)2]- (1) (C5iPr5 =...
Aromatic π-stacking is a weakly attractive, noncovalent interaction often found in biological macromolecules and synthetic supramolecular chemistry. The weak nondirectional nature of can present challenges the design materials owing to their weak, nature. However, when aromatic π-systems contain an unpaired electron, stronger attraction involving face-to-face π-orbital overlap possible, resulting covalent so-called "pancake" bonds. Two-electron, multicenter single pancake bonds are well...
A diuranium(<sc>v</sc>) bis-nitride complex supported by siloxide ligands displays remarkable reactivity in ambient conditions with small molecules such as CS<sub>2</sub>, CO<sub>2</sub>, CO and H<sub>2</sub> resulting N–C N–H bond formation. The nitride linker also leads to an unusually strong antiferromagnetic coupling between uranium(<sc>v</sc>) ions.
Terminal uranium nitrides have so far proven impossible to isolate by photolysis of azides. Here we report the second ever example an isolated terminal uranium(VI) nitride. We show that nitride [NBu4][U(OSi(OtBu)3)4(N)], 3, can be prepared upon with UV light U(IV) azide analogue. This is achieved careful tailoring precursor and reaction conditions. Complex 3 stable under ambient conditions but reacts readily electrophiles (H+ CO).
Multimetallic cooperativity is believed to play a key role in the cleavage of dinitrogen nitrides (N3–), but mechanism remains ambiguous due lack isolated intermediates. Herein, we report reduction complex [K2{[UV(OSi(OtBu)3)3]2(μ-O)(μ-η2:η2-N2)}], B, with KC8, yielding tetranuclear tetranitride cluster [K6{(OSi(OtBu)3)2UIV}3{(OSi(OtBu)3)2UVI}(μ4-N)3(μ3-N)(μ3-O)2], 1, novel example N2 nitride by diuranium complex. The structure 1 remarkable, as it contains unique uranium center bound four...
Molecular uranium nitride complexes were prepared to relate their small molecule reactivity the nature of U[double bond, length as m-dash]N[double m-dash]U bonding imposed by supporting ligand. The U4+-U4+ complexes, [NBu4][{(( t BuO)3SiO)3U}2(μ-N)], [NBu4]-1, and [NBu4][((Me3Si)2N)3U}2(μ-N)], 2, synthesised reacting NBu4N3 with U3+ [U(OSi(O Bu)3)2(μ-OSi(O Bu)3)]2 [U(N(SiMe3)2)3], respectively. Oxidation 2 AgBPh4 gave U4+-U5+ analogue, [((Me3Si)2N)3U}2(μ-N)], 4. previously reported...
The synthesis and reactivity of uranium compounds supported by the tris-tert-butoxysiloxide ligand is surveyed. multiple binding modes tert-butoxysiloxide have proven very well suited to stabilize highly reactive homo- heteropolymetallic complexes that shown an unusual high towards small molecules such as CO2, CS2, chalcogens azides. Moreover, these ligands allowed isolation dinuclear nitride oxide bridged in various oxidation states. ability trap alkali ions or leads unprecedented based...
Uranium nitride compounds are important molecular analogues of uranium materials such as UN and UN2 which effective catalysts in the Haber-Bosch synthesis ammonia, but nitrides remains a challenge studies reactivity nature bonding poorly developed. Here we report first bridged complexes containing U(vi) provide unique comparison U(vi)/U(vi), U(vi)/U(v) U(v)/U(v) systems. Oxidation bis-nitride [K2{U(OSi(O t Bu)3)3(μ-N)}2], 1, with mild oxidants yields U(v)/U(vi) [K{U(OSi(O 2...
The P2X purinergic receptor 7 (P2X7) has an essential role in inflammation, innate immunity, tumor progression, neurodegenerative diseases, and several other leading subsequently to the development of P2X7 modulators. AZ11645373 is a frequently studied antagonist tool compound but always used as racemic mixture. Racemic can be separated into its respective enantiomers by chiral chromatography, albeit small batches, these were stereochemically intact over two years later, high-performance...
Despite their synthetic interest and potential attractive properties the preparation of heteroleptic U(III) complexes containing monodentate ligands remains challenging. Here we report synthesis, structure magnetic three two siloxide donors in coordination sphere. The bis‐siloxide monoiodide complex [U(OSi(OtBu)3)2I(thf)3], 1 provides a very precursor for accessing rationally modify binding angle between strongly donating ligands. reacted with macrocyclic to yield [[U(OSi(OtBu)3)2(crypt)]I,...
Thorium nitrides are likely intermediates in the reported cleavage and functionalization of dinitrogen by molecular thorium complexes attractive compounds for study multiple bond formation f-element chemistry, but only one example nitride isolable from solution was reported. Here, we show that stable multimetallic azide/nitride can be generated reduction azide precursors─a route has failed so far to produce Th nitrides. Once isolated, clusters, M3Th═N═Th (M = K or Cs), solutions probably due...
The synthesis of acylpyrazolone salts and their complexes main group elements, transition metals, lanthanides, actinides are described characterized inter alia by means single-crystal X-ray crystallography, NMR, IR spectroscopies. consist two, three, or four acylprazolone ligands bound to the metal atom, resulting in a structurally diverse set coordination with (distorted) octahedral, pentagonal-bipyramidal, antiprismatic arrangements. Several proved be polymeric solid state including...
The reaction of a terminal Mo(II) nitride with U(III) complex yields heterodimetallic U-Mo which is the first example transition metal-capped uranium nitride. triply bonded to U(V) and singly Mo(0) supports interaction. This compound shows reactivity toward CO oxidation.
Reduction of the neutral U IV –X–U (X = O or S) complexes supported by aryloxide ligands yielded /U III and analogues. Notably, –S–U is first example a U( iii ) sulphide-bridged complex.
The P2X purinergic receptor 7 (P2X7) has an essential role in inflammation, innate immunity, tumor progression, neurodegenerative diseases, and several other leading subsequently to the development of P2X7 modulators. AZ11645373 is a frequently studied antagonist tool com-pound, but always as racemic mixture. Racemic can be separated, into its respective enantiomers by chiral chromatography, albeit small batches, these were stereochemically in-tact over year later, HPLC analysis. On higher...
The P2X purinergic receptor 7 (P2X7) has an essential role in inflammation, innate immunity, tumor progression, neurodegenerative diseases, and several other leading subsequently to the development of P2X7 modulators. AZ11645373 is a frequently studied antagonist tool com-pound, but always as racemic mixture. Racemic can be separated, into its respective enantiomers by chiral chromatography, albeit small batches, these were stereochemically in-tact over year later, HPLC analysis. On higher...