Andrea Granados
A5060249625- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
University of California, San Francisco
2020-2023
Global Viral
2020-2022
Abbott (United States)
2020-2022
Universidad Católica de Santa Fe
2020
Abstract In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) killed over a million people, including >25,000 in New York City (NYC) alone. The COVID-19 pandemic caused by SARS-CoV-2 highlights clinical needs to detect infection, track strain evolution, and identify biomarkers of disease course. To address these challenges, we designed fast (30-minute) colorimetric test (LAMP) for infection from naso/oropharyngeal swabs large-scale shotgun...
Abstract Given the limited availability of serological testing to date, seroprevalence SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 two San Francisco Bay Area populations. Seroreactivity was 0.26% 387 hospitalized patients admitted for non-respiratory indications and 0.1% 1,000 blood donors early April 2020. We additionally describe longitudinal dynamics immunoglobulin-G (IgG), immunoglobulin-M (IgM), vitro neutralizing...
ABSTRACT An outbreak of novel betacoronavirus, SARS-CoV-2 (formerly named 2019-nCoV), began in Wuhan, China December 2019 and the COVID-19 disease associated with infection has since spread rapidly to multiple countries. Here we report development DETECTR, a rapid (∼30 min), low-cost, accurate CRISPR-Cas12 based lateral flow assay for detection from respiratory swab RNA extracts. We validated this method using contrived reference samples clinical infected US patients demonstrated comparable...
SARS-CoV-2 infection elicits a distinct host response in nasal swabs and blood that can be used to diagnose COVID-19.
ABSTRACT We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% 387 hospitalized patients admitted for non-respiratory indications and 0.1% 1,000 blood donors. additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, vitro neutralizing antibody titers COVID-19 patients. Neutralizing antibodies rise tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within...
The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of infant remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort 53 infants age 2 weeks to 3 years (80.7 billion reads), their mothers (9.8 reads) examine compare viromes. asymptomatic consisted bacteriophages, nonhuman dietary/environmental viruses, human-host predominantly...
Abstract The potential role of enteric viral infections and the developing infant virome in affecting immune responses to oral poliovirus vaccine (OPV) is unknown. Here we performed metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination compared findings 16 age-matched United States (US). In 14 infants, available post-vaccination serum were tested for polio-neutralizing antibodies. abundance (p = 0.006) richness 0.013) eukaryotic...
Abstract The virome of the human gut and its development in early life are poorly understood. Here we performed viral metagenomic sequencing on stool samples from a multiethnic, socioeconomically diverse cohort 53 infants collected longitudinally over their first 3 years mothers to investigate compare viromes. asymptomatic infant consisted bacteriophages, dietary/environmental viruses, pathogenic contrast material virome, which sequence reads viruses were absent or present at extremely low...