NFDI4DS | UHH-SEMS - Publication Details

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome (WGS), whole-exome (WES), and RNA (RNA-seq), to examine germline genomes from 309 prospectively identified children with newly diagnosed (85%) relapsed/refractory (15%) cancers, unselected for type. Eighty-six percent patients harbored diagnostic (53%), prognostic (57%), therapeutically relevant (25%), and/or...

10.1158/2159-8290.cd-20-1631 article EN cc-by-nc-nd Cancer Discovery 2021-07-23

Data from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<div>Abstract<p>Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome (WGS), whole-exome (WES), and RNA (RNA-seq), to examine germline genomes from 309 prospectively identified children with newly diagnosed (85%) relapsed/refractory (15%) cancers, unselected for type. Eighty-six percent patients harbored diagnostic (53%), prognostic (57%), therapeutically...

10.1158/2159-8290.c.6549437 preprint EN 2023-04-03

Data from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<div>Abstract<p>Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome (WGS), whole-exome (WES), and RNA (RNA-seq), to examine germline genomes from 309 prospectively identified children with newly diagnosed (85%) relapsed/refractory (15%) cancers, unselected for type. Eighty-six percent patients harbored diagnostic (53%), prognostic (57%), therapeutically...

10.1158/2159-8290.c.6549437.v1 preprint EN 2023-04-03

Supplementary Figure S4 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S4</p>

10.1158/2159-8290.22540643 preprint EN cc-by 2023-04-03

Supplementary Figure S3 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S3</p>

10.1158/2159-8290.22540646 preprint EN cc-by 2023-04-03

Supplementary Figure S2 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S2</p>

10.1158/2159-8290.22540649.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S2 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S2</p>

10.1158/2159-8290.22540649 preprint EN cc-by 2023-04-03

Supplementary Figure S6 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S6</p>

10.1158/2159-8290.22540637.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S1 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S1</p>

10.1158/2159-8290.22540652.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S1 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S1</p>

10.1158/2159-8290.22540652 preprint EN cc-by 2023-04-03

Supplementary Figure S4 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S4</p>

10.1158/2159-8290.22540643.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S3 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S3</p>

10.1158/2159-8290.22540646.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S5 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S5</p>

10.1158/2159-8290.22540640 preprint EN 2023-04-03

Supplementary Figure S5 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S5</p>

10.1158/2159-8290.22540640.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S6 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S6</p>

10.1158/2159-8290.22540637 preprint EN cc-by 2023-04-03

Supplementary Figure S7 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S7</p>

10.1158/2159-8290.22540631.v1 preprint EN cc-by 2023-04-03

Supplementary Figure S7 from Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing

OPENALEX - Publications

Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato David A. Wheeler and 52 more

<p>Supplementary Figure S7</p>

10.1158/2159-8290.22540631 preprint EN cc-by 2023-04-03

LACE+ is marginally predictive of 30-day readmission after stroke (P11-5.027)

OPENALEX - Publications

Muhib Khan Freddie Hildreth Diana Haggerty Jay Knight Małgorzata Miller and 10 more

<h3>Objective:</h3> We aimed to investigate predictors of 30-day same hospital readmission after stroke and incorporate these factors in a predictive model. <h3>Background:</h3> Hospital readmissions is costly negatively impact outcomes. <h3>Design/Methods:</h3> Patients discharged with primary diagnosis ischemic intracerebral hemorrhage between 1/1/2018 12/31/2020 were included. Transient Ischemic Attack (TIA) patients excluded from the analysis. LACE+ index, age, smoking status, care...

10.1212/wnl.0000000000201970 article EN Neurology 2023-04-25

Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer

OPENALEX - Publications

David A. Wheeler Scott Newman Joy Nakitandwe Chimene Kesserwan Elizabeth M. Azzato and 44 more

Abstract Clinical genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. In the Genomes for Kids study (NCT02530658) we used a three-platform sequencing approach, including whole genome (WGS), exome (WES) and RNA sequencing, to examine paired germline genomes from prospectively identified children with cancer. The goal was assess potential comprehensive next generation elucidate molecular mechanisms underlying formation investigate this...

10.1158/1538-7445.am2021-642 article EN Cancer Research 2021-07-01