Diabetes is the most common metabolic disorder in both developing and non-developing countries, a well-recognized global health problem. The WHO anticipates an increase cases from 171 million 2000 to 366 by 2030. In present study, we focus on preparation of pyrimidine derivatives as potential antidiabetic antimicrobial agents. Thein vivoeffect total serum glucose concentration, cholesterol antioxidant activity was assessed adult male albino Wister rats compared reference drug glimperide....

Recently, numerous plant-based synthesis techniques have been used to develop metal nanoparticles. The current study uses the medicinal plant extract of couroupita guianensis (CG) petals create biogenic silver nanoparticles in an environmentally friendly manner. Different techniques, including ultraviolet–visible spectroscopy (UV–vis), Fourier Transformation Infrared (FTIR), X-ray diffraction (XRD), and Dynamic Light Scattering (DLS) analysis, are evaluate synthesized From XRD results...

In the present study, versatile multifunctional unreported triazolo[1,5-a]quinoline derivatives were prepared. Compounds 1–19 synthesized by adopting appropriate synthetic routes and pharmacologically evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) Caucasian breast adenocarcinoma (MCF-7), addition to antibacterial antifungal activities. Compound 4 demonstrated strong inhibitory effects whereas compounds 8 19 exhibited...

This article reports on a new rout to synthesize of copper nanoparticles with aqueous extracts from Couroupita guianensis Aubl. is an environmentally friendly, inexpensive, and time-saving method producing nanoparticles. The petals, stems, bark, leaves were used the Plant induce reduction Cu2+ ions into CuNP act as protection stabilization agents. formation CuNPs was monitored throughout synthesis process by absorption spectra UV–Vis spectrophotometer. Fourier transfer infrared (FTIR)...

Synthesis and biological activity of some new 1-benzyl 1-benzoyl-3-heterocyclic indole derivatives Starting from 1-benzyl- ( 2a ) 1-benzoyl-3-bromoacetyl indoles 2b heterocyclic, 2-thioxoimidazolidine 4a, b ), imidazolidine-2,4-dione 5a, pyrano(2,3- d )imida-zole 8a, 9a, 2-substituted quinoxaline 11a, b-17a, triazolo(4,3- a )quinoxaline 18a, 19a, were synthesized evaluated for their antimicrobial anticancer activities. Antimicrobial screening performed with concentrations 0.88, 0.44 0.22 μg...

Nanomaterial is a rapidly growing area that used to create variety of new materials and nanotechnology applications from medical, pharmaceuticals, chemical, mechanical, electronics several environmental industries including physical, chemical biological nanoparticles are very important in our daily life. Nanoparticles with leaf extract the healthy plant research using biosynthesis methods. Because it’s as an environmentally ecofriendly, other than traditional physical strategies. In...

A monolithic methacrylate packed 96-tips device was used for the extraction of busulfan and cyclophosphamide in whole blood samples. Using a set, 96-well plate could be handled about 2 min. The key aspect phase is that material can offer both good capacity low-back-pressure properties. validation methodology showed accuracy values quality-control samples were between 99 113% busulfan, 103 110% cyclophosphamide. inter-day precision ranged from 7.0 to 12% 13 16% standard calibration curves...

In recent years, molecular modeling has become an important technique for drug discovery and pharmaceutical science. The objective of this study is to determine the antibacterial, anti-inflammatory anti-nociceptive activities a new series pyrazoles, oxadiazoles sugar hydrazines 5-nitroindolin-2- one derivatives. protocol was applied using MOE (Molecular Operating Environment) software. Synthetic compounds 1, 3, 8, 9, 10 12 were most active compounds, as antiinflammatory studied binding...

Microextraction by packed sorbent (MEPS) was used to handle whole mice blood samples.MEPS as an online rapid sample-preparation method, followed liquid chromatography with tandem mass spectrometry (LC-MS/MS).Cyclophosphamide in a model compound.The new method reduced the handling time and cost could small volumes of samples (20 μL).The lower limit quantification (LLOQ) 0.1μg/mL.The accuracy quality-control (QC) ranged from 107 110 %.The within-day variation within range 2.0-7.0%(C.V.%) while...

Objectives A new series of 2-(1,5,6-trimethyl-1H-benzo[d]imidazole-2-carbonyl)-2,3-dihydro-1H-pyrazole-4-carbonitrile (6a,b), (1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazol-5-yl)(phenyl) methanone (9–11), and (1,3,4-oxadiazol-2-yl)-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (14–16) derivatives were synthesized evaluated for their antioxidant antimicrobial activities; in addition, quantitative structure–activity relationships molecular docking investigated. Methods The target...

A series of VOII, NiII, CuII, CoII, MnII, CdII and ZnII complexes new Schiff base ligand resulting form 4-aminoantipyrine Furobenzopyrone were prepared. The structure newly synthesized compounds (1-8) was proven by studying their elemental analyses, spectral data (IR, NMR, UV-vis), molar conductivity magnetic susceptibility. In addition the in vitro antimicrobial activi-ty all examined. results cleared that nickel zinc exhibited promising activity compared with standard drug (chloramphenicol).

Fabrics treated with many chemicals and different technologies to give them good functional properties. In this study, new coloured materials were prepared used for colouring finishing fabrics in one step. Pyrimidine derivatives are compounds that have attracted much attention recent years because of their broad spectrum biological activities.We synthesized various pyrimidine such as aminothioxopyrido (2,3-d) materials, which dyeing textile materials. The effect the nature substituents on...

BACKGROUND: Therapies for diabetes mellitus are still meeting failure in most cases, especially the developed stages of disease due to incredible associating complications. Hence, there is a need continuous development curative therapies that stubborn disease.
 AIM: We aimed investigate antidiabetic effects one popular plants cultivated Egypt, C. olitorius.
 METHODS: Phytochemical screening total alcoholic extract Corchorus olitorius leaves and its aqueous chloroform fractions...

Objective The aim of this study (part II) is to evaluate the antibacterial, anti-inflammatory, and antinociceptive activities a series 1H-1,2,4-triazol-3-yl)phenylimino)(methylbenzyl)-5-nitroindolin-2-ones, 1H-pyrazole-1-carbonyl)phenylimino)-1-(p-methylbenzyl)-5-nitroindolin-2-ones, 3-(4-(1,3,4-oxadizine-6-one)phenylimino)-1-(p-methylbenzyl)-5-nitroindolin-2-ones, 1,3,4-oxadiazol-2-yl)phenylimino)-1-(p-methylbenzyl)-5-nitroindolin-2-ones...

Clothing comfort is essential for any wearer.It desirable all apparel products.Tactile and thermal factors are related to human comfort.The aim of this study the effect new dye based on (Pyrido Pyrimidine Heptadinone Derivative) as colour some attributes KES mechanical properties wool fabric well tensile, bending shear properties.It was found that dyeing process affect tensile energy extensibility significantly in warp direction, rigidity hysteresis directions, weft both directions.A...