A5008462070- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Microbial metabolism and enzyme function
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Vasculitis and related conditions
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Cardiac Fibrosis and Remodeling
- Immune cells in cancer
- Neonatal and Maternal Infections
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2024
Scripps Research Institute
2024
Mahatma Gandhi University
2018-2020
Neutrophils, the first cells that come to infection site, regulate recruitment and functioning of monocytes. Alteration in neutrophil secretions during pathological conditions result altered monocyte functions. As hyperglucose hyperisulin are known prime innate immune system, role secretion activating or priming neutrophils monocytes these was studied. Neutrophils were isolated treated with hyperglucose, hyperinsulin + vitro supernatants collected. Neutrophil then studied for their functions...
Abstract Collagen crosslinking, mediated by lysyl oxidase, is an adaptive mechanism of the cardiac repair process initiated fibroblasts postmyocardial injury. However, excessive crosslinking leads to wall stiffening, which impairs contractile properties left ventricle and heart failure. In this study, we investigated role periostin, a matricellular protein, in regulation oxidase response angiotensin II TGFβ1. Our results indicated that periostin silencing abolished TGFβ1‐mediated...
Endosomal Toll-like receptors (eTLRs) are essential for the sensing of non-self through RNA and DNA detection. Here, using spatiotemporal analysis vesicular dynamics, super-resolution microscopy studies, functional assays, we show that endomembrane defects associated with deficiency small GTPase Rab27a cause delayed eTLR ligand recognition, defective early signaling, impaired cytokine secretion. Rab27a-deficient neutrophils retention eTLRs in amphisomes internalization. Extracellular...