Eager to learn from private sector trends, practitioners in (semi)public organizations across the world have recently turned their eyes concept of work engagement improve employee performance. Studies show that is a more robust predictor performance than, for example, satisfaction. The goal this study find out whether effects on attitudinal, behavioral, and outcomes within semipublic public are also as high expected these relationships differ between public, semipublic, sector. results...

Abstract This paper addresses the arguments in favour of both decentralization and centralization public policy making. It points out that same are sometimes used to advance either claim different countries opposite support claim. Clearly, inherent features far from obvious. A closer look at attention given issue by political parties national level four European reveals becomes an these periods as a cause arguments, which rather reflect dominant values culture than refer properties itself....

Purpose – The purpose of this article is to discuss the idea that new public management (NPM) would be passé . Design/methodology/approach based on a review existing theories. Findings argues NPM has two dimensions, namely minimization role government vis-à-vis society and improvement internal performance sector. Whereas first dimension indeed more disputed nowadays does not imply also goes for second dimension. conclusion calls explanatory empirical research in order explain increasing...

Two phase I drug interaction studies were performed with oral enzalutamide, which is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC).

Oral enzalutamide (160 mg once daily) is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This article describes pharmacokinetics and its active metabolite N-desmethyl enzalutamide. Results are reported from five clinical studies. In a dose-escalation study (n = 140), half-life was 5.8 days, steady state achieved by day 28, accumulation 8.3-fold, exposure approximately dose proportional 30–360 mg/day, intersubject variability ≤30 %. mass balance 6),...

Abstract Pritelivir is a helicase‐primase inhibitor active against HSV. Two human mass balance trials (a multiple‐dose trial and single‐dose trial) were performed to characterize the absorption, distribution, metabolism, excretion of 100 mg oral pritelivir combined with single microdose 14 C‐pritelivir. Blood, urine, feces samples collected up 26 days postdose. The plasma half‐life was 63‐67 hours. Overall, 92% 66% administered dose recovered in multiple trials, respectively. low recovery...

The article presents the results of an empirical analysis interdependence, cooperation and conflict. show a curvilinear relationship between these three variables. Interdependence is measured by four indicators: politico-military, economic, institutional diplomatic ties nation-states. structure interdependence relations in period 1950-60 analysed means multidimensional scaling techniques. conflict accordingly. conclusions from are: first, that aspects are closely related; second, relatively...

In the past 20 years, decentralization has been proposed as a strategy for enhancing public participation. Aid-providing organizations, such World Bank, stimulated processes in several countries hope that this would promote civic empowerment, diminish corruption, enhance efficiency, and improve service delivery. This assumption forms basis comparative analysis into relation between participation at local level Brazil, Japan, Russia Sweden. A multi-level regression using data of Democracy...

Repetitive reorganizations cause change fatigue, which creates employee resistance to further organizational change. This paper investigates how such fatigue arises. The results show that uncertainty and workload are mediating factors. effect of is not moderated by the perceived success prior reorganization, participation in process, or leadership characteristics. It only slightly satisfaction employees about communication during reorganization.

This paper and a special issue of the journal addresses varying capacity local governments in different regions world. Local Government Capacity as concept can have definitions, but this framework it seems adequate to simply define `the ability government perform their functions an effective efficient way´. The idea behind argues that order improve especially where its performance is severely needed, more differentiated approach capacity-building required, pinpointing main factors inhibiting...

This article discusses the honesty of local politicians and public administrators in 17 countries. First, it goes into deontological, consequential, virtue, dialogic ethics. Based on a large-scale survey, this concludes that ethos (general principle) is universal value, which conforms to deontological principles. Regarding ethics (the application principle practice), however, important differences between these elites are seen. The explanation for sought at individual organizational level....

Netherlands), the developments of contracts like 'Citizen's charters' (United Kingdom, France), increasing number formalized rights, such as right to information, comprehension, be listened to, intervene, correct and professional behavior controls evaluation development Ombudsman systems, albeit in different forms, Sweden, Finland, Spain, Australia, Canada, The Netherlands France (see Rowat, 1983).Such procedures are aimed at improving democratic features policymaking processes.These laid...

5-Hydroxytryptamine_1A (5-HT_1A) receptors have been implicated in the pathophysiology and treatment of anxiety depression, are a target for novel drug development. This is first study examining human brain vivo occupancy by novel, selective, silent 5-HT_1A antagonist. 2-[4-[4-(7-Chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2<i>H</i>)-one-1,1-dioxide (DU 125530), compound clinical development, has potential applications mood...

Purpose While there is an urgent need for clean water in Ghana and Nigeria, governments lack the financial means to do much address this need. This does not mean that improving access impossible. On contrary, paper argued engaging citizens through co-production, as already being done developed countries fields of care-giving, waste management, healthcare community policing, could provide a successful strategy. The purpose examine how public facilities are managed improve sustain domestic use...

Abstract Pritelivir is a novel viral helicase‐primase inhibitor active against herpes simplex virus. In vitro drug‐drug interaction studies indicated that pritelivir has the potential for clinically relevant interactions on cytochrome P450 (CYP) enzymes 2C8, 2C9, 3A4, and 2B6, intestinal uptake transporter organic anion transporting polypeptide (OATP) 2B1 efflux breast cancer resistance protein (BCRP). This was evaluated in 2 clinical trials. 1 trial substrates flurbiprofen (CYP2C9),...

Abstract. This article addresses the question of how far turnover among those who make policy is relevant for understanding changing views. Does age or generation determine attitudes about making, does period in which new makers get dominant positions changes attitudes? The research based on a survey conducted 1989, and repeated 1996 2000, local politicians senior administrators Sweden, Netherlands, Russia, Lithuania Belarus. conclusion that period‐effects account large portion attitude...

O artigo apresenta resultados de pesquisa empírica que buscou verificar o impacto da pobreza sobre Índice Desenvolvimento Educação Básica em escolas ensino fundamental mais 5.500 municípios brasileiros, comparando desempenho estaduais e municipais. Foram analisados os dados 2005, 2007 2009 por meio regressões lineares simples, resíduos correlações parciais. Os mostram a tem um forte no escolar, chegando explicar até 60% variação. autores discutem obtidos vis-à-vis às atuais tendências...