A5085066634- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- HER2/EGFR in Cancer Research
- Cytomegalovirus and herpesvirus research
- Nitric Oxide and Endothelin Effects
- HIV Research and Treatment
- Toxin Mechanisms and Immunotoxins
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Alzheimer's disease research and treatments
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
- Renin-Angiotensin System Studies
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- Escherichia coli research studies
- Cystic Fibrosis Research Advances
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Genetic Associations and Epidemiology
- Infectious Encephalopathies and Encephalitis
Medical University of South Carolina
2014-2025
Smilow Cancer Hospital
2025
Cancer Genetics (United States)
2025
National Institute for Occupational Safety and Health
2014
Centers for Disease Control and Prevention
2014
College of Charleston
2014
Uniformed Services University of the Health Sciences
2007
Ralph H. Johnson VA Medical Center
2001
This study explores the role of mevalonate inhibitors in activation NF-kbeta and induction inducible nitric oxide synthase (iNOS) cytokines (TNF-alpha, IL-1beta, IL-6) rat primary astrocytes, microglia, macrophages. Lovastatin sodium phenylacetate (NaPA) were found to inhibit LPS- cytokine-mediated production NO expression iNOS astrocytes; this inhibition was not due depletion end products pathway (e.g., cholesterol ubiquinone). Reversal inhibitory effect lovastatin on LPS-induced by...
Background VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of HIV-1 envelope glycoprotein (Env) that currently being evaluated in Phase IIb adult prevention efficacy trial. VRC01LS modified version VRC01, designed for extended serum half-life by increased binding affinity to neonatal Fc receptor. Methods and findings This I dose-escalation study HIV-negative healthy adults was conducted Vaccine Research Center (VRC) at National Institutes Health...
The sphingomyelin signal transduction pathway is known to play a role in mediating the action of various cytokines. Here we examined possible signaling on lipopolysaccharide (LPS)- and cytokine-mediated production NO expression inducible nitric-oxide synthase (iNOS). Sphingomyelinase (SMase) treatment astrocytes increased cellular levels ceramide without induction production. However, incubation LPS or cytokine-stimulated with SMase by increasing intracellular cell-permeable analogs (C2-...
Nitric oxide produced by inducible nitric-oxide synthase (iNOS) in different brain cells response to various cytokines plays an important role the pathophysiology of stroke and other neurodegenerative diseases. This study underlines importance cAMP inhibiting induction NO production lipopolysaccharide (LPS) rat primary astrocytes. Compounds (forskolin, 8-bromo-cAMP, (Sp)-cAMP) that increase activate protein kinase A (PKA) were found inhibit LPS- cytokine-mediated as well expression iNOS,...
Nitric oxide produced by inducible nitric-oxide synthase (iNOS) in different cells including brain response to proinflammatory cytokines plays an important role the pathophysiology of stroke and other neurodegenerative diseases. The present study underlines importance protein phosphatase (PP) 1 2A regulation differential expression iNOS rat primary astrocytes macrophages. Compounds (calyculin A, microcystin, okadaic acid, cantharidin) that inhibit PP were found stimulate lipopolysaccharide...
Abstract Immunoglobulin GM (γ marker) and KM (κ allotypes—encoded by immunoglobulin heavy chain G ( IGHG ) κ constant IGKC genes—have been shown to be associated with immune responsiveness a variety of self nonself antigens. The aim the present investigation was determine whether allelic variation at loci antibody poly-N-acetyl-D-glucosamine (PNAG), broadly-conserved surface polysaccharide expressed many microbial pathogens. In addition, we wished Fcγ receptor 2 A FCGR2A genotypes, which...
Abstract Surveillance of individuals at high‐risk pancreatic cancer using CAPS criteria and other expert consensus guidelines may result in earlier detection some cases; therefore, clinicians are responsible for appropriately identifying referring these to appropriate pancreas screening programs. This study aimed assessing the perspective, knowledge, clinical practices genetic counselors surveyed nationwide towards identification utilization One hundred eighty‐nine who listed “Cancer” as...
BACKGROUND. HIV-1–specific broadly neutralizing monoclonal antibodies (bNAbs) have emerged as promising interventions with the potential to effectively treat and prevent HIV-1 infections. We conducted a phase I clinical trial evaluating potent CD4-binding site–specific (CD4bs-specific) bNAbs VRC01LS VRC07-523LS in people (PWH) not receiving antiretroviral therapy (ART).
10613 Background: Genetic testing for breast cancer susceptibility genes is a crucial component of clinical care patients with early-onset (EOBC) diagnosed < age 50 implications treatment and surgical decision-making, future surveillance, cascade genetic family. Limited data exist regarding prevalence pathogenic/likely pathogenic variants (P/LPV) patterns family history (FH) across diverse patient populations merit further research given the rise in EOBC rates. This study examines cohort...
Antibody-dependent cell-mediated cytotoxicity (ADCC), which links the innate and adaptive arms of immunity, is a major host immunosurveillance mechanism against tumours, as well leading underlying clinical efficacy therapeutic antibodies such cetuximab trastuzumab, target tumour antigens, human epidermal growth factor receptor (HER)1 HER2, respectively. Immunoglobulin (Ig)G antibody-mediated ADCC triggered upon ligation Fcγ (FcγR) to Fc region IgG molecules. It follows that genetic variation...
Human cytomegalovirus (HCMV) has been proposed as an amplifying agent for at least some of the spectrum systemic sclerosis (SSc; scleroderma). In support this hypothesis, antibodies to HCMV late protein UL94 have detected in majority SSc patients a study involving Caucasian subjects from Italy. The aim investigation was determine whether elevated levels anti-UL94 are present African American and U.S. We further wished there significant difference between diffuse limited forms disease. IgG...
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone equally likely to develop HCMV-spurred implying the presence of host genetic factors that might modulate immunity this virus. Here, we show antibody responsiveness HCMV glycoprotein B (gB) significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB levels were highest in 17/17 homozygotes, intermediate 3/17 heterozygotes, and lowest 3/3...
Antibody-dependent, cell-mediated cytotoxicity (ADCC) is one of the major mechanisms underlying clinical efficacy anticancer monoclonal antibodies (mAbs), such as mucin 1 (MUC1)-targeting molecule HuHMFG1. IgG trigger ADCC upon interaction with Fcγ receptors (FcγRs) expressed on surface immune effector cells. Polymorphisms affecting FcγRs are known to influence magnitude ADCC, but impact natural genetic variations in Fc-coding sequence, γ marker (GM) allotypes, has not been adequately...
Summary Cyclin B1 is a checkpoint protein that regulates cell division from G2 to the M phase. Studies in mice have shown cyclin vaccine-induced immunity significantly delayed or prevented spontaneous cancer development later life. We hypothesized if these results showing protective effect of anti-cyclin antibodies could be extrapolated human condition, cancer-free individuals should higher levels endogenous than patients with cancers characterized by over-expression this tumour-associated...
We examined the role that immunoglobulin GM and KM allotypes-genetic markers of gamma kappa chains, respectively-play in outcome hepatitis C virus (HCV) infection white Americans. A total 119 persons who had cleared HCV 111 with persistent were genotyped for presence several determinants. Persistent was more than three times as likely (odds ratio, 3.50; P= .01) subjects carriers GM3 allele those noncarriers. These results show particular alleles may be important determinants infection.
Tumour-associated antigen human epidermal growth factor receptor 2 (HER2) is over-expressed in 25-30% of breast cancer patients and associated with poor prognosis. Naturally occurring anti-HER2 antibody responses have been described HER2 over-expressing tumours. There significant interindividual variability responsiveness, but the host genetic factors responsible for this are poorly understood. The aim present investigation was to determine whether immunoglobulin markers [GM (genetic...