A5019211813- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Insect and Pesticide Research
- Parasites and Host Interactions
- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
- Traditional Chinese Medicine Analysis
- Plant biochemistry and biosynthesis
- Oral microbiology and periodontitis research
- Biological Activity of Diterpenoids and Biflavonoids
- Toxoplasma gondii Research Studies
- Endodontics and Root Canal Treatments
- Marine Sponges and Natural Products
- Plant-Derived Bioactive Compounds
- Ginger and Zingiberaceae research
- Trypanosoma species research and implications
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Helminth infection and control
Universidade de Franca
2016-2025
Natura (Brazil)
2014-2015
Universidade de São Paulo
1999-2006
Universidade de Ribeirão Preto
2006
Abstract Gold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area volume ratio, and surfaces that can be easily modified ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, eco-friendly approach. Brazilian Red Propolis (BRP), product bees, exhibits anti-inflammatory, anti-tumor, antioxidant, antimicrobial activities. Here, we described biosynthesis BRP (AuNP ) its fractions hexane , AuNP...
The antimicrobial activity of four labdane-type diterpenes isolated from the oleoresin Copaifera langsdorffii as well two commercially available (sclareol and manool) was investigated against a representative panel microorganisms responsible for periodontitis. Among all evaluated compounds, (−)-copalic acid (CA) most active, displaying very promising MIC value (3.1 µg mL−1; 10.2 µM) key pathogen (Porphyromonas gingivalis) involved in this infectious disease. Moreover, CA did not exhibit...
Abstract In the present work, anticariogenic activities of nine labdane type‐diterpenes and four sesquiterpenes were investigated. Among these metabolites, (‐)‐copalic acid (CA) was most active compound displaying MIC values very promising (ranging from 2.0 to 6.0 µg/mL) against main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, mutans, mitis, sanguinis Lactobacillus casei . Time kill assays performed with CA primary causative agent ( mutans ) revealed...
Seven pimarane type-diterpenes re-isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against the following main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, mutans, mitis, sanguinis Lactobacillus casei. The compounds ent-pimara-8(14),15-dien-19-oic acid (PA); ent-8(14),15-pimaradien-3beta-ol; ent-15-pimarene-8beta,19-diol; ent-8(14),15-pimaradien-3beta-acetoxy sodium salt derivative of PA most active...
The in vitro schistosomicidal effects of the essential oil Ageratum conyzoides L. (Ac-EO) against adult worms Schistosoma mansoni is reported this paper. Concerning activity, Ac-EO was considered to be active, but less effective than positive control (praziquantel, PZQ) terms separation coupled pairs, mortality, decrease motor and tegumental alterations. However, caused an interesting dose-dependent reduction number eggs S. mansoni. Precocene I (74.30%) (E)-caryophyllene (14.23%) were...
In Brazilian folk medicine, Tetradenia riparia (Hochst.) Codd. (Lamiaceae) is used to treat toothaches and dental abscesses diseases induced by worms, bacteria, or fungi. This paper aims investigate the chemical composition antibacterial effects of essential oil obtained from leaves (TR-EO) grown in Southeastern Brazil against a representative panel oral pathogens. We evaluated activity TR-EO terms minimal inhibitory concentration (MIC). identified aromadendrene oxide (14.0%), (E,E)-farnesol...
Many studies have reported that medicinal plant extracts can inhibit oral pathogen growth or adhesion to surfaces and therefore reduce dental caries formation. The addition of these products like mouthwashes dentifrices is considered an important strategy in control. In this sense, we developed a Mikania glomerata extract with high ent-kaurenoic acid content (KAMg). So, work describes the preparation such development validated HPLC-DAD method determine its (KA) content. Herein it also...
The dichloromethane crude extract from the roots of Viguiera arenaria (VaDRE) has been employed in an antimicrobial screening against several bacteria responsible for human pathologies. main diterpenes isolated this extract, as well two semi-synthetic pimarane derivatives, were also investigated pathogens that significantly inhibited by (MIC values lower than 100 microg mL(-1)). VaDRE was active only Gram-positive microorganisms. compounds ent-pimara-8(14),15-dien-19-oic acid (PA); PA sodium...
Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used the determination minimum inhibitory concentration (MIC) bactericidal (MBC) Porphyromonas gingivalis, Prevotella nigrescens, intermedia, buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, viscosus,...
Abstract The chemical composition and the in vitro schistosomicidal effects of essential oil Plectranthus neochilus (PN‐EO) grown Southeast Brazil was studied. β ‐Caryophyllene ( 1 ; 28.23%), α ‐thujene 2 12.22%), ‐pinene 3 12.63%), 4 6.19%), germacrene D 5 5.36%), caryophyllene oxide 6 5.37%) were major constituents. This differed from that previously reported for specimens harvested Africa. Concerning activity against adult Schistosoma mansoni worms, PN‐EO considered to be active, but less...
Background: Natural products display numerous therapeutic properties (e.g., antibacterial activity), providing the population with countless benefits.Therefore, search for novel biologically active, naturally occurring compounds is extremely important.The present paper describes action of Copaifera langsdorffii oleoresin and ten isolated from this against multiresistant bacteria; it also reports antiproliferative activity (-)-copalic acid.Methods: MICs MBCs were used to determine...
Antibiotic-resistant bacteria have emerged from the widespread use of antibiotics worldwide and prompted search for new sources antimicrobial substances. Pinus spp. contain several bioactive compounds consisting mainly terpenes, terpenoids some other aromatic aliphatic constituents. These exert important biological effects, pine oils found wide application in industry. In present study, we evaluated potential activity resin-oil elliottii its major compound dehydroabietic acid (DA) against...
Pimaradienoic acid (PA; ent-pimara-8(14),15-dien-19-oic acid) is a pimarane diterpene found in plants such as Vigueira arenaria Baker (Asteraceae) the Brazilian savannas. Although there evidence on analgesic and vitro inhibition of inflammatory signaling pathways, paw edema by PA, its anti-inflammatory effect deserves further investigation. Thus, objective present study was to investigate PA carrageenan-induced peritoneal inflammation mice. Firstly, we assessed leukocyte recruitment cavity...
Abstract Brazilian green and red propolis stand out as commercial products for different medical applications. In this article, we report the antimicrobial activities of hydroalcoholic extracts (EGP) (ERP) propolis, well guttiferone E plus xanthochymol (8) oblongifolin B (9) from against multidrug‐resistant bacteria (MDRB). We undertook minimal inhibitory (MIC) bactericidal (MBC) concentrations, inhibition biofilm formation (MICB 50 ), catalase, coagulase, DNase, lipase, hemolysin assays,...
The conventional treatment of congenital toxoplasmosis is mainly based on the combination sulfadiazine and pyrimethamine. However, therapy with these drugs associated severe side effects resistance, requiring study new therapeutic strategies. There are currently many studies natural products, including Copaifera oleoresin, showing actions against some pathogens, as Trypanosoma cruzi Leishmania . In present study, we investigated leaf hydroalcoholic extract oleoresin from multijuga Toxoplasma...
Two kaurane diterpenes, ent-kaur-16(17)-en-19-oic acid (KA) and 15-β-isovaleryloxy-entkaur- 16(17)-en-19-oic (KA-Ival), isolated from Aspilia foliacea, the methyl ester derivative of KA (KA-Me) were evaluated against oral pathogens. was most active compound, with MIC values 10 μg mL -1 following microorganisms: Streptococcus sobrinus, mutans, mitis, sanguinis, Lactobacillus casei. However, did not show significant activity salivarius Enterococcus faecalis, equal to 100 200 , respectively....
The in vitro activity of the crude hydroalcoholic extract aerial parts Miconia langsdorffii Cogn. was evaluated against promastigote forms L. amazonensis, causative agent cutaneous leishmaniasis humans. bioassay-guided fractionation this led to identification triterpenes ursolic acid and oleanolic as major compounds fraction that displayed highest activity. Several semi-synthetic derivatives were prepared, find out whether more active could be obtained. Among these acid-derived substances,...
The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected Brazil against Schistosoma mansoni worms are reported this paper. caused a significant decrease motor activity at 50 µg/mL as minimal concentration after 24 h. This also death all parasites and separation coupled pairs into individual male female 100 viability adult worm groups treated with TE-EO was similar to that praziquantel (positive control). In addition,...