A5010801048- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Autism Spectrum Disorder Research
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Prostate Cancer Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- BRCA gene mutations in cancer
- Molecular Biology Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Biosensors and Analytical Detection
- Prostate Cancer Treatment and Research
- Microfluidic and Capillary Electrophoresis Applications
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
New York University Abu Dhabi
2020-2024
McGill University
2021
New York University
2021
Khalifa University of Science and Technology
2020
Mohammed Bin Rashid University of Medicine and Health Sciences
2019
The interaction of immune cells with drugs and/or other cell types should be mechanistically investigated in order to reduce attrition new drug development. However, they are currently only limited technologies that address this need. In our work, we developed initial but significant building blocks enable such immune-drug studies. We a novel microfluidic platform replicating the Lymph Node (LN) microenvironment called LN-on-a-chip, starting from design all way microfabrication,...
Abstract Background In recent years, several hundred autism spectrum disorder (ASD) implicated genes have been discovered impacting a wide range of molecular pathways. However, the underpinning ASD, particularly from point view ‘brain to behaviour’ pathogenic mechanisms, remains largely unknown. Methods We undertook study investigate patterns spatiotemporal and cell type expression ASD-implicated by integrating large-scale brain single-cell transcriptomes (> million cells) de novo...
Abstract In this work, for first time, circulating tumor cells (CTCs) are captured on an open biofunctionalized substrate with multiplexing capability. This is achieved by developing a new microfluidic probe (MFP) integrated radially staggered herringbone (HB) elements microvortex generation. The tool, named as (HB‐MFP), channel‐less system physically separated bottom capture and top fluidics delivery system. concept allows functionalizing the multiple biorecognition ligands (in stripes of...
Schematic representation of the methodology developed for creating cryopreservable high throughput paper-based arrays 3D tumor models drug screening applications.
Genetic testing is becoming an essential tool for breast cancer (BC) diagnosis and treatment pathway, particularly important early detection prevention. The purpose of this study was to explore the diagnostic yield targeted sequencing high priority BC genes. We have utilized a cost-effective approach actionable genes (BRCA1, BRCA2, ERBB2 TP53) in homogeneous patient cohort from Bangladesh (n = 52) by using tumor blood samples. Blood derived revealed 25.58% (11/43) clinically relevant...
Abstract Background In recent years, several hundred autism spectrum disorder (ASD) implicated genes have been discovered impacting a wide range of molecular pathways. However, the underpinning ASD, particularly from point view ‘brain to behaviour’ pathogenic mechanisms, remains largely unknown. Methods We undertook study investigate patterns spatiotemporal and cell type expression ASD-implicated by integrating large-scale brain single transcriptomes (> million cells) de novo loss...