A5083913291- Pancreatic function and diabetes
- Central Venous Catheters and Hemodialysis
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Diabetes and associated disorders
- Vascular Procedures and Complications
- Cannabis and Cannabinoid Research
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- T-cell and Retrovirus Studies
- Bipolar Disorder and Treatment
- Biochemical and Molecular Research
- Xenotransplantation and immune response
- Assisted Reproductive Technology and Twin Pregnancy
- Organ Transplantation Techniques and Outcomes
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Acute Kidney Injury Research
Vrije Universiteit Brussel
2016-2022
Universitair Ziekenhuis Brussel
2017-2021
Mathys (Netherlands)
2021
Center for Beta Cell Therapy in Diabetes
2017-2020
Alginate (Alg)-encapsulated porcine islet cell grafts are developed to overcome limitations of human transplantation. They can generate functional implants in animals when prepared from fetal, perinatal, and adult pancreases. Implants have not yet been examined for efficacy establish sustained, metabolically adequate β-cell mass (FBM) comparison with cells. This study immune-compromised mice demonstrates that subcutaneous Alg-encapsulated prenatal cells 4 × 105 β-cells form, over 10 weeks, a...
Device-encapsulated human stem cell-derived pancreatic endoderm (PE) can generate functional β-cell implants in the subcutis of mice, which has led to start clinical studies type 1 diabetes. Assessment formed mass (FBM) and its correlation with vivo metabolic markers guide translation. We recently reported ex characteristics device-encapsulated embryonic (hES)-PE mice that had established a metabolically adequate FBM during 50-week follow-up. Cell suspensions from retrieved indicated number...
Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft dysfunction due to an initial period of warm ischemia. This procurement condition can also affect the yield beta cells in islet isolates donor pancreases, and hence their use transplantation. The present study uses data collected generated by our Beta Cell Bank compare number DCD III (n = 141) with that brain (DBD, n 609), before culture, examines influence variables. cell per III-organ was...
Introduction The prophylactic use of recombinant tissue plasminogen activator once weekly reduces the incidence rate tunneled cuffed catheter (TCC) malfunction and bacteremia as compared to exclusive heparin locking solution. Restricting thrombolytic agents patients with a history thrombotic TCC could be more cost effective. We conduct multicenter, double-blind, randomized controlled trial test hypothesis that urokinase lock will reduce by 50% in prevalent hemodialysis malfunction. Methods...
Background: There are few data to inform decisions about the optimal management of occluded tunneled cuffed hemodialysis catheters with thrombolytic locking solutions. The effect dose, dwell-time, and number administrations remains controversial. Methods: In this retrospective single-center review used between 2010 2014, restoration blood flow as well pre- post-pump pressures after either short (30 min) or prolonged (48–72 h) administration 100,000 IU urokinase solution was evaluated in all...
Background The efficacy and cost-effectiveness of prophylactic thrombolytic locks in hemodialysis patients at high-risk thrombotic dialysis catheter dysfunction is uncertain. We investigated this question a double-blinded randomized controlled study. Methods Prevalent from 8 Belgian units, with ≥2 separate episodes their tunneled cuffed during the 6 months before inclusion, were to either: taurolidine heparin thrice weekly (control arm) or same twice week combined urokinase once longest...
Patients fulfilling criteria for euthanasia can choose to donate their organs after circulatory death [donors (DCD V)]. This study assesses the outcome of islet cell isolation from DCD V pancreases. A procedure procurement provided 13 pancreases preserved in Institut Georges Lopez-1 preservation solution and following acirculatory warm ischemia time under 10 minutes. Islet outcomes are compared with those reference donors brain (DBD, n = 234) a cohort controlled III, 29) procured same...
Detection of amyloid in intraportal islet implants type 1 diabetes patients has been proposed as cause their functional decline. The present study uses cultured adult human islets devoid to examine conditions its formation. After injection patients, deposits <15 µm diameter were identified 5%-12% beta cell containing aggregates, 3-76 months posttransplant. Such also formed glucose-controlling the kidney diabetic mice but not failing implants. Alginate-encapsulated during culture when...
A proper functioning access to the peritoneal cavity is first and foremost requirement start dialysis. Most commonly, dialysis catheters are inserted using a surgical approach. Laparoscopic catheter insertion recommended technique because it offers employ advanced adjunctive procedures that minimize risk of mechanical complications. In patients with low complications, such as without prior history abdominal surgery or peritonitis, in ineligible for general anesthesia, percutaneous approach...
Long-term survival after beta cell transplantation in patients with diabetes mellitus type 1 Belgium: a review and retrospective study Diabetes (DM1) is condition associated loss of functional mass the need for intensive insulin treatment. Despite technological advances recent decades (continuous glucose monitoring, pumps), there are still who suffer from problematic hypoglycemia severe glycemic variability. Beta may offer them therapeutic solution. Belgium has several experience this...