A5022060952- Fungal and yeast genetics research
- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Machine Learning in Bioinformatics
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Antifungal resistance and susceptibility
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Microbial Metabolic Engineering and Bioproduction
- Antimicrobial Peptides and Activities
- Advanced Proteomics Techniques and Applications
- Hippo pathway signaling and YAP/TAZ
- Fungal Infections and Studies
- Glycosylation and Glycoproteins Research
- Biochemical and Structural Characterization
- Cell Adhesion Molecules Research
University of Oulu
2024
University of Macau
2017-2023
Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and potential solution to the multi-drug resistance problem. In particular, short-length AMPs have been shown enhanced activities, higher stability, lower toxicity human cells. We present (≤30 aa) AMP prediction method, Deep-AmPEP30, developed based on an optimal feature set PseKRAAC reduced amino acids composition convolutional neural network. On balanced benchmark dataset 188 samples, Deep-AmPEP30 yields improved...
Abstract The extracellular matrix (ECM) undergoes substantial changes during prostate cancer (PCa) progression, thereby regulating PCa growth and invasion. Herein, a meta‐analysis of multiple cohorts is performed which revealed that downregulation or genomic loss ITGA1 ITGA2 integrin genes associated with tumor progression worse prognosis. Genomic deletion both activated epithelial‐to‐mesenchymal transition (EMT) in benign epithelial cells, enhancing their invasive potential vitro converting...
The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence stress in pathogens. Here we define circuitry that enables the fungal pathogen Candida albicans couple cell cycle dynamics wall induced by echinocandins, a front-line class antifungal drugs. We discover C. transcription factor Cas5 proper which inhibit β-1,3-glucan synthesis. has distinct transcriptional targets under basal conditions, activated...
ABSTRACT Transcription factors (TFs) play a crucial role in regulating gene expression living organisms, and any malfunction their functions can lead to severe physiological consequences. The regulation of TFs occurs at multiple levels, with autogenous being common mode where the TF is dependent on its own function. Although bioinformatics analysis promoter sequences frequently used predict events, it not entirely reliable. In this study, we present simple yet effective strategy identify TF....