A5020244548- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Zebrafish Biomedical Research Applications
- BIM and Construction Integration
- Mitochondrial Function and Pathology
- Mobile Agent-Based Network Management
- Dyeing and Modifying Textile Fibers
- Transport Systems and Technology
- Adipose Tissue and Metabolism
- Wireless Communication Networks Research
- Smart Parking Systems Research
- Conservation Techniques and Studies
- Optical Wireless Communication Technologies
- Advanced Optical Network Technologies
- Advanced Photonic Communication Systems
- Advanced Wireless Network Optimization
University of Minho
2008-2024
Columbia University Irving Medical Center
2021
Universidade Federal do Rio Grande do Sul
2009
University of Beira Interior
2008
Extracellular vesicles (EVs), including small EVs (sEVs) such as exosomes, exhibit great potential for the diagnosis and treatment of brain disorders, representing a valuable tool precision medicine. The latter demands high-quality human biospecimens, especially in complex disorders which pathological specimen heterogeneity, well diverse individual clinical profile, often complicate development therapeutic schemes patient-tailored treatments. Thus, collection characterization physiologically...
O estudo investiga a correlação entre inadimplência e desemprego no Nordeste brasileiro durante o primeiro segundo trimestres de 2024, considerando os impactos econômicos da pandemia COVID-19. Utilizando dados do IBGE Serasa Experian, aplica análises estatísticas para compreender como afeta capacidade das pessoas honrar compromissos financeiros. A pesquisa revela que, embora exista uma correlação, esta varia em intensidade, indicando que não é único fator contribui inadimplência. Fatores...
Abstract Chronic stress and elevated levels of glucocorticoids (GCs), the main hormones, accelerate Alzheimer’s disease (AD) onset progression. A major driver AD progression is spreading pathogenic Tau protein between brain regions, precipitated by neuronal secretion. While high GC are known to induce intraneuronal pathology ( i.e . hyperphosphorylation, oligomerization) in animal models, their role trans-neuronal unexplored. Here, we find that GCs promote secretion full-length, primarily...
Type 2 diabetes increases the risk for dementia, including Alzheimer’s disease (AD). Pioglitazone (Pio), a pharmacological agonist of peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in management AD symptoms, albeit through mostly unknown mechanisms. We here investigated Pio counter synaptic malfunction loss, characteristic pathology its accompanying cognitive deficits. Results from experiments on primary mouse...
Abstract Chronic stress and elevated glucocorticoids (GCs), the major hormones, are risk factors for Alzheimer’s disease (AD) promote AD pathomechanisms, including overproduction of toxic amyloid-β (Aβ) peptides intraneuronal accumulation hyperphosphorylated Tau protein. The latter is linked to downregulation small GTPase Rab35, which mediates degradation via endolysosomal pathway. Whether Rab35 also involved in Aβ remains an open question. Here, we find that hippocampal levels decreased not...
A very high speed FSO (free space optics) link has been successfully implemented for purposes of requirement applications, at the University Campus. An experimental performance evaluation this carried out various OSI levels (1, 4, and 7). Several results are presented discussed.
Summary Chronic stress and elevated levels of glucocorticoids (GCs), the main hormones, accelerate Alzheimer’s disease (AD) onset progression. A major driver AD progression is spreading pathogenic Tau protein between brain regions, precipitated by neuronal secretion. While high GC are known to induce intraneuronal pathology ( i.e. hyperphosphorylation, oligomerization) in animal models, their role trans-neuronal unexplored. Here, we find that GCs promote secretion full-length, vesicle-free,...
Archaeology is a science that uses multiple disciplines to ensure the validity of archaeological data and accurately support theoretical foundations. computer graphics create credible virtual representations sites artifacts, which are used for interpretation, research purposes archiving. Accurate an site rely on balanced mixture techniques, some discussed in this communication aplied I century roman fountain. Different imaging techniques were integrated - point cloud from total station, 3D...
Abstract Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer’s disease (AD), yet the factors that precipitate dysfunction AD are poorly understood. Chronic environmental stress elevated glucocorticoids (GC), major hormones, associated with increased risk AD, have been shown to trigger intracellular accumulation downstream Tau-dependent dysfunction. However, mechanisms through which GC disrupt clearance degradation neurons remain...
Sulfides are important base metal ores, usually associated with metals and coal. Their extraction generates reactive wastes that stored in piles and/or tailings dams. Those final destinations often the main source of environmental problems mining sector. The river waters can present signs acid mine drainage (AMD), responsible for degradation aquatic ecosystem. So, target study is to investigate impact AMD systems, focus on quality potential ecological risk. area at Iberian Pyrite Belt, São...
Abstract Chronic stress and elevated levels of glucocorticoids (GCs), the main hormones, accelerate Alzheimer’s disease (AD) onset progression. A major driver AD progression is spreading pathogenic Tau protein between brain regions, precipitated by neuronal secretion. While high GC are known to induce intraneuronal pathology ( i.e. hyperphosphorylation, oligomerization) in animal models, their role trans-neuronal unexplored. Here, we find that GCs promote secretion full-length, vesicle-free,...
Abstract Background In the era of Precision Medicine, extracellular vesicles (EVs) exhibit great potential for theragnostic brain disorders such as Alzheimer’s disease (AD), a complex with no effective treatment and poorly understood risk factors, where pathological heterogeneity diverse clinical presentations complicate development precise patient‐tailored therapies. Thus, collection characterization physiologically relevant EVs, well study its precipitating/risk are utmost importance....