A5085389972- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Vascular Anomalies and Treatments
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Liver Disease and Transplantation
Istanbul University-Cerrahpaşa
2018-2024
Istanbul University
2018-2024
Patients with chronic thromboembolic pulmonary hypertension (CTEPH) in countries limited resources have, to date, been poorly represented registries.
Abstract Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, whose build-up scar tissue induced by several molecules. Gastrin-releasing peptide (GRP) released from neuroendocrine cells, alveolar macrophages, and some nerve endings in the lung. A possible role of GRP IPF unclear. We aimed to investigate fibrotic response GRP, at cellular level MRC5 A549 cell lines. The proliferative effects on these cells were evaluated using BrdU, immunoblotting, immunofluorescence qRT-PCR for...
Identifying and understanding the microstructural changes within wall of pulmonary artery (PA) is crucial for elucidating disease mechanisms guiding treatment strategies. We assessed utility optical coherence tomography (OCT) in identifying such segmental/subsegmental PAs compared morphological variations WHO group 4 hypertension associated with Behcet Disease (BD), Takayasu arteritis (TA) chronic thromboembolic (CTEPH). Idiopathic arterial (IPAH) patients served as controls.Methods Results:...
This study aimed to analyze the role of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with persistent chest symptoms after acute PE.Patients aged between 18 and 80 years who were followed up for PE screened which persisted anticoagulation treatment. Patients suffering other types (PH) or metastatic malignancies excluded this study. Demographic functional data included collected. The underwent transthoracic echocardiography ventilation/perfusion (VQ) scans. Also, invasive...
<b>Introduction:</b> Pulmonary neuroendocrine cells (PNECs) play important roles in lung biology, such as cell proliferation and differentiation, the development. Their possible pulmonary fibrosis have not been investigated detail. Gastrin-releasing peptide (GRP) released from PNECs leads to by increased immunoreactivities of pSmad2/3, collagen alpha-smooth muscle actin (α-SMA) mice lungs. However, molecular mechanism this effect has elucidated study. <b>Aims objectives:</b> We aimed...