A5065582200- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Genomics and Rare Diseases
- Retinal Development and Disorders
- Smoking Behavior and Cessation
- Substance Abuse Treatment and Outcomes
- Behavioral Health and Interventions
- Healthcare Systems and Technology
- Eating Disorders and Behaviors
- Public Health and Nutrition
- Health Literacy and Information Accessibility
- Genomic variations and chromosomal abnormalities
- Corneal surgery and disorders
- Media Influence and Health
- Telemedicine and Telehealth Implementation
- Genetics and Neurodevelopmental Disorders
- Global Public Health Policies and Epidemiology
- Electronic Health Records Systems
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cannabis and Cannabinoid Research
- Ophthalmology and Visual Health Research
- Systemic Lupus Erythematosus Research
- Mobile Health and mHealth Applications
University College London
2023-2025
Moorfields Eye Hospital
2023-2025
Moorfields Eye Hospital NHS Foundation Trust
2023-2025
NIHR Moorfields Biomedical Research Centre
2024
King's College London
2020-2023
Nightingale Hospital
2022
Queen Mary University of London
2019-2020
Middlesex University
2015
Introduction Inherited retinal diseases (IRD) are a leading cause of visual impairment and blindness in the working age population. Mutations over 300 genes have been found to be associated with IRDs identifying affected gene patients by molecular genetic testing is first step towards effective care patient management. However, diagnosis currently slow, expensive not widely accessible. The aim current project address evidence gap IRD an AI algorithm, Eye2Gene, accelerate democratise service....
Abstract Purpose To quantify relevant fundus autofluorescence (FAF) image features cross-sectionally and longitudinally in a large cohort of inherited retinal diseases (IRDs) patients. Design Retrospective study imaging data (55-degree blue-FAF on Heidelberg Spectralis) from Participants Patients with clinical molecularly confirmed diagnosis IRD who have undergone FAF 55-degree at Moorfields Eye Hospital (MEH) the Royal Liverpool (RLH) between 2004 2019. Methods Five interest were defined:...
To quantify relevant fundus autofluorescence (FAF) features cross-sectionally and longitudinally in a large cohort of patients with inherited retinal diseases (IRDs). Retrospective study imaging data. Patients clinical molecularly confirmed diagnosis IRD who have undergone 55° FAF at Moorfields Eye Hospital (MEH) the Royal Liverpool between 2004 2019. Five interest were defined: vessels, optic disc, perimacular ring increased signal (ring), relative hypo-autofluorescence (hypo-AF),...
Background: Inherited Retinal Diseases (IRDs) are the leading cause of blindness in young people UK. Despite significant improvements genomics medicine, diagnosis these conditions remains challenging, with many patients enduring lengthy diagnostic odysseys and even after genetic testing around 40% them do not receive a definite diagnosis. This survey aims to explore experience individuals affected IRDs, their relatives, friends caregivers, potential acceptability an AI technology, such as...
Background Inherited retinal diseases (IRDs) are the leading cause of blindness in young people UK. Despite significant improvements genomics medicine, diagnosis these conditions remains challenging, and around 40% do not receive a definite genetic after extensive testing. This survey aims to investigate experience individuals affected by IRDs, their relatives, friends caregivers, focusing on care diagnostic journey. Additionally, it explores potential acceptability artificial intelligence...
Abstract There is growing demand for emergency-based eyecare services where the majority of those attending do not require urgent ophthalmic management. The Royal College Ophthalmologists have recommended upskilling and supporting allied health professionals to support delivery, machine learning algorithms could help. A mixed methods study was conducted evaluate usability an artificial intelligence (AI) powered online triage platform ophthalmology. interface, usability, safety acceptability...
Background/Aims Recent decades have seen significant advances in both structural and functional testing of retinal disease. However, the current clinical value specific modalities, as well future trends, need to be clearly identified order highlight areas for further development routine care trials. Methods We designed a modified two-round Delphi study obtain opinion multidisciplinary group 33 international experts involved field disease management/research determine level agreement...
This study examined the possible intergenerational transmission of eating beliefs and intentions between 60 mothers their adult children. Maternal restrictive feeding practices were correlated with mothers' own healthy attitudes subjective norms, children's norms. Mothers' Adult to eat healthily predicted by perceived behavioural control, also control. may be involved in shaping into adulthood but child have less an influence.
Abstract Introduction Co-use of tobacco and cannabis is highly prevalent among users associated with poorer cessation outcomes. This study explored the barriers enablers influencing stop-smoking practitioners’ ability to provide optimal support co-users. Aims Methods Online semi-structured interviews were audio recorded. Interviewees (n = 20) UK-based certified practitioners. An interview schedule informed by “capability”, “opportunity”, “motivation” (COM-B) model was designed explore...
As high-throughput sequencing is increasingly applied to the molecular diagnosis of rare Mendelian disorders, a large number patients with diverse phenotypes have their genetic and phenotypic data pooled together uncover new gene-phenotype relations. We introduce Phenogenon, statistical tool that combines, Human Phenotype Ontology (HPO) annotated patient phenotypes, gnomAD allele population frequency, Combined Annotation Dependent Depletion (CADD) score for variant pathogenicity, in order...
Background Inherited retinal diseases (IRDs) are a leading cause of blindness in children and working age adults the United Kingdom other countries, with an appreciable socioeconomic impact. However, by definition, IRD data individually rare, as result, this patient group has been underserved research. Researchers need larger amounts these rare to make progress field, for example, through development gene therapies. The challenge how find available researchers most productive way. MyEyeSite...
Purpose: Inherited retinal disorders (IRD) are a complex group of conditions. By developing the first patient-reported experience measurement (PREM) questionnaire tailored for individuals with IRD participating in natural history studies, we gathered information on individuals' views their while they involved research. Methods: Adults who (i) were enrolled study taking place at Moorfields Eye Hospital (London, UK), (ii) had attended least two visits, (iii) most recent one being less than...
Abstract Introduction According to UK guidelines, stop smoking practitioners are expected be open and supportive towards e-cigarette users. As adequate support from can instrumental for smokers successfully quit smoking, it is crucial explore the challenges that face when advising on use. Aim This qualitative study explores patients e-cigarettes. Methods A was conducted with semi-structured interviews 10 four services in London. Face were recorded transcribed verbatim. Inductive thematic...
<sec> <title>BACKGROUND</title> Inherited retinal diseases (IRDs) are a leading cause of blindness in children and working age adults the United Kingdom other countries, with an appreciable socioeconomic impact. However, by definition, IRD data individually rare, as result, this patient group has been underserved research. Researchers need larger amounts these rare to make progress field, for example, through development gene therapies. The challenge how find available researchers most...
Introduction: Co-use of tobacco and cannabis in the UK is highly prevalent among users associated with poorer cessation outcomes. The aim this study was to explore barriers enablers influencing support offered co-users by stop smoking practitioners. Methods: Online semi-structured qualitative interviews were audio recorded. Interviewees (n = 20) certified practitioners working as specialist practitioners, midwives, mental health nurses, general pharmacists, wellbeing or dentists. An...