A5025022011- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- stochastic dynamics and bifurcation
- Neural Networks and Applications
- Neurobiology and Insect Physiology Research
- Cell Image Analysis Techniques
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Plant and Biological Electrophysiology Studies
- Visual perception and processing mechanisms
- Memory and Neural Mechanisms
- Vestibular and auditory disorders
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Advanced Fluorescence Microscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Olfactory and Sensory Function Studies
- Single-cell and spatial transcriptomics
- Electrochemical Analysis and Applications
- Receptor Mechanisms and Signaling
- Conducting polymers and applications
Hebrew University of Jerusalem
2016-2025
University of Szeged
2024
HUN-REN Institute of Experimental Medicine
2024
Edmond and Lily Safra Children's Hospital
2010-2023
Institute of Life Sciences
2003-2019
Max Planck Institute of Neurobiology
2017
Institute of Neurobiology
2014
Center for Interdisciplinary Studies
2014
Hebrew College
2010
Madison Group (United States)
2008
The firing reliability and precision of an isopotential membrane patch consisting a realistically large number ion channels is investigated using stochastic Hodgkin-Huxley (HH) model. In sharp contrast to the deterministic HH model, biophysically inspired model reproduces qualitatively different characteristics spike in response DC fluctuating current input neocortical neurons, as reported by Mainen & Sejnowski (1995). For inputs, timing highly unreliable; are significantly increased for...
The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for cortical column. L5b cells have been subject extensive experimental modeling studies, yet conductance-based models these that faithfully reproduce both their perisomatic Na+-spiking behavior well key active properties, including Ca2+ spikes back-propagating action potentials, are still lacking. Based on large body recordings from soma...
We present a novel framework for automatically constraining parameters of compartmental models neurons, given large set experimentally measured responses these neurons. In experiments, intrinsic noise gives rise to variability (e.g., in firing pattern) the voltage repetitions exact same input. Thus, common approach fitting by attempting perfectly replicate, point point, single chosen trace out spectrum variable does not seem do justice data. addition, finding error function that faithfully...
The size and shape of dendrites axons are strong determinants neuronal information processing. Our knowledge on structure function is primarily based brains laboratory animals. Whether it translates to human not known since quantitative data "full" morphologies lacking. Here, we obtained brain tissue during resection surgery reconstructed basal apical individual neurons across all cortical layers in temporal cortex (Brodmann area 21). Importantly, did correlate etiology, disease severity, or...
The advanced cognitive capabilities of the human brain are often attributed to our recently evolved neocortex. However, it is not known whether basic building blocks neocortex, pyramidal neurons, possess unique biophysical properties that might impact on cortical computations. Here we show layer 2/3 neurons from temporal cortex (HL2/3 PCs) have a specific membrane capacitance ( C m ) ~0.5 µF/cm 2 , half commonly accepted 'universal' value (~1 for biological membranes. This finding was...
1. Intracellular recordings were made from neurons in slices guinea‐pig frontal cortex. In 50% of the cells, sustained subthreshold voltage oscillations evoked by long (> 6 s) depolarizing pulses. The peak‐to‐peak amplitude these was less than 5 mV and frequency dependent, increasing with depolarization 4 (near rest) to 20 Hz (at 30 depolarization). 2. impedance‐frequency relationship both oscillating non‐oscillating cells studied intracellular injection sinusoidal current linearly...
Synaptic transmission in the neocortex is dynamic, such that magnitude of postsynaptic response changes with history presynaptic activity. Therefore each carries information about temporal structure preceding input spike train. We quantitatively analyze previous interspike intervals, contained single responses dynamic synapses, using methods from theory applied to experimentally based deterministic and probabilistic phenomenological models depressing facilitating synapses. show for any given...
1. Measurements of input resistance (RN), time constant (tau 0), and electrotonic length (Lpeel) were derived from intracellular voltage changes produced by injection current pulses in six type-identified triceps surae alpha-motoneurons. The motoneurons labeled with horseradish peroxidase subsequently reconstructed measured serial sections. These quantitative morphological physiological data incorporated into detailed computer models the motoneurons. 2. Steady-state dynamic used to determine...
1. A compartmental model was employed to investigate the electrical behavior of a dendritic spine having excitable membrane at head. Here we used Hodgkin and Huxley equations generate properties; in some cases kinetics were modified get longer duration action potential. Passive assumed for both stem shaft. Synaptic input modeled as transient conductance increase (alpha-function) that lies series with battery (that corresponds an excitatory or inhibitory synaptic equilibrium potential). 2....
Pyramidal neurons in the cerebral cortex characteristically give rise to an apical dendrite, whose distal dendritic branches layer I are covered with spines. These spines known be sites of synaptic connections, but physiological properties and functional significance their responses still largely unknown. The main function attributed thus far these responses, situated at a great distance from neuronal cell body, is slow background modulation impulse output axon. In pursuing computer...
Manor, Yair, John Rinzel, Idan Segev, and Yosef Yarom. Low-amplitude oscillations in the inferior olive: a model based on electrical coupling of neurons with heterogeneous channel densities. J. Neurophysiol. 77: 2736–2752, 1997. The mechanism underlying subthreshold olivary cells is not known. To study this question, we developed single-compartment, two-variable, Hodgkin-Huxley-like for olive neurons. consists leakage current low-threshold calcium current, whose kinetics were experimentally...
1. Purkinje cells (PCs) from guinea-pig cerebellar slices were physiologically characterized using intracellular techniques. Extracellular caesium ions used to linearize the membrane properties of PCs near resting potential. Under these conditions average input resistance, RN, was 29 M omega, system time constant, tau 0, 82 ms and cable length, LN, 0.59. 2. Three fully reconstructed following physiological measurements staining with horseradish peroxidase. Assuming that each spine has an...
Neurons in the mammalian CNS receive 10 4 -10 5 synaptic inputs onto their dendritic tree. Each of these may fire spontaneously at a rate few spikes per second. Consequently, cell is bombarded by several hundred synapses each and every millisecond. An extreme example cerebellar Purkinje (PC) receiving approximately 100,000 excitatory from parallel fibers (p.f.s) spines covering thin branchlets. What effect p.f.s activity on integrative capabilities PC? This question explored theoretically...