A5081071962- Rheumatoid Arthritis Research and Therapies
- Blood disorders and treatments
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Drug-Induced Adverse Reactions
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Natural Compounds in Disease Treatment
- Spondyloarthritis Studies and Treatments
- Eosinophilic Disorders and Syndromes
- Ocular Diseases and Behçet’s Syndrome
- Drug-Induced Ocular Toxicity
- Pharmacovigilance and Adverse Drug Reactions
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Guizhou University
2022-2024
Affiliated Hospital of Guizhou Medical University
2023-2024
Guiyang College of Traditional Chinese Medicine
2023-2024
Hydroxychloroquine (HCQ) is used as a traditional disease-modifying antirheumatic drugs (DMARDs), for the treatment of autoimmune diseases such rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, it can cause serious adverse reactions, including hyperpigmentation skin bull's-eye macular lesions. Here, we present case HCQ-induced lesions in patient who received HCQ RA. A 65-year-old female developed blurred vision multiple areas over body one month after 3 years Based...
Abstract Dermatomyositis (DM) is a poorly prognostic autoimmune disease the pathogenesis of which multifactorial and not clearly defined. DM may be influenced by genes, environment, immunity. The typical manifestations are Gottron rash, heliotrope rash on shoulders buttocks, erythema around fingernails, excessive keratosis epidermis, mechanic's hands, interstitial lung (ILD), among others. Anti‐melanoma differentiation‐associated 5 gene (MDA5) antibody has been strongly associated with DM....
Introduction Acute generalized exanthematous pustulosis (AGEP) is a rare condition characterized by superficial pustules following drug ingestion or infection. Currently, there no clear link between rheumatism and AGEP. It has been described that hydroxychloroquine (HCQ) cause of acute epidermal necrolysis (AGEP). Presently, are limited studies on HCQ-induced We aimed to explore the clinical features associated gene expression AGEP induced after HCQ treatment exposure in rheumatology...
Rheumatoid arthritis (RA) is a chronic inflammatory disease, which typically affects the small joints of hands and feet. Anti-rheumatism drugs should be promptly administered upon diagnosis. Without standardized treatment, patients are prone to different degrees deformities in later stages disease development, negatively impact quality life. We here report case 52-year-old woman with an 18-year history RA. After intermittent immunotherapy anti-rheumatism drugs, patient presented multiple...
Rationale: Acute generalized exanthematous pustulosis (AGEP) is a serious adverse skin reaction characterized by the rapid appearance of densely distributed, small, sterile pustules with erythema. However, its pathogenesis not fully understood. Hydroxychloroquine widely used for treatment autoimmune diseases. Some patients presenting AGEP have IL36RN and CARD14 gene mutations. Our report describes patient rheumatoid arthritis associated hydroxychloroquine newly discovered mutation. Patient...
Abstract Objectives To evaluate the efficacy and safety of adalimumab (ADA) combined with Tripterygium wilfordii Hook F (TwHF) in treatment methotrexate (MTX)‐inadequate response patients rheumatoid arthritis (RA). Methods In this multicenter, open‐label, randomized controlled clinical trial, 64 RA inadequate to MTX were 1:1 randomly assigned into or control groups. The group was treated ADA combination TwHF, for 24 weeks. primary endpoint percentage having low disease activity (2.6 ≤...