A5080915658- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Endometriosis Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Occupational and environmental lung diseases
- Uterine Myomas and Treatments
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- Mechanical stress and fatigue analysis
- Fatigue and fracture mechanics
- Wnt/β-catenin signaling in development and cancer
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Soft tissue tumor case studies
- S100 Proteins and Annexins
- BRCA gene mutations in cancer
Nagasaki University
2016-2025
Japan Community Healthcare Organization
2020
Nagasaki Medical Center
2020
Nagasaki University Hospital
2011-2019
Kagawa University
2019
Kumamoto University
2019
Community Partners
2019
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2015
To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members NPH.We performed whole-exome sequencing (WES) on a multiple individuals NPH and identified candidate gene. Then we generated knockout mouse using CRISPR/Cas9 confirm the effect of gene pathogenesis hydrocephalus.In WES, loss-of-function variant CFAP43 that segregated disease. encoding cilia- flagella-associated protein is preferentially expressed testis. Recent studies have revealed...
A high serum level of saturated free fatty acids (FFAs) is associated with the development nonalcoholic liver disease (NAFLD). X-box binding protein-1 (XBP-1) activated by FFA treatment upon splicing. XBP-1 a transcription factor induced endoplasmic reticulum (ER) stress sensor endoribonuclease inositol-requiring enzyme 1 alpha (IRE1α). However, role in NAFLD remains relatively unexplored. Toyocamycin was recently reported to attenuate activation XBP-1, possibly inducing conformational...
We examined the hypothesis that antibiotic treatment with or without gonadotropin releasing hormone agonist (GnRHa) may decrease intrauterine infection consequent in tissue inflammation, cell proliferation and angiogenesis human endometriosis.This is a prospective non-randomized observational study. Endometrial/endometriotic samples were collected during surgery from 53 women endometriosis 47 control who treated levofloxacin (LVFX, 500 mg, once per os) GnRHa (1.88 mg/IM for 3 months) before...
Matsuda K, Miura S, Kurashige T, Suzuki Kondo H, Ihara M, Nakajima Masuzaki H & Nakashima M(2011) Histopathology59, 441–451 Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis Aims: A defective damage response can result (GIN) lead to transformation cancer. As (53BP1) localizes at the sites (DSBs) rapidly forms (NF), presence 53BP1 NF be considered an indicator DSBs reflecting GIN....
In a previous report, we proposed that analysis of 53BP1 expression by immunofluorescence could be useful tool in estimating the level genomic instability (GIN), as well malignant potential, thyroid tumours. an attempt to clarify value new molecular marker for aggressiveness papillary microcarcinoma (PMC), assessed association between type and clinicopathological features such tumour size, extrathyroidal invasion, lymph node metastasis BRAF(V) (600E) mutation PMC.A total 36 surgically...
Is there any change in the distribution of microvilli and microtubules apical endometria women with adenomyosis?We observed damage an axonemal alteration characterized by abnormal longitudinal bundles within adenomyosis.Human adenomyosis has a negative impact on female fertility. Abnormal utero-tubal sperm transport, tissue inflammation toxic effect chemical mediators have been proposed as contributing factors. Inflammation-induced mucosal cilia Fallopian tube reported. However, information...
Copy number alterations and loss of heterozygosity are associated with increasing tumor grade bladder cancer stage. Our previous study suggested that co-expression Ki-67 p53-binding protein 1 (53BP1) could provide an indicator abnormal DNA damage response (DDR) pathway. The present investigated 53BP1 expression as a novel molecular marker in urothelial carcinoma (UC) using tissues total 40 cases including normal urothelium, papilloma, low-grade UC, or high-grade UC. Double-label...
Objective: This study aimed to demonstrate that the cribriform-morular variant (CMV) of papillary thyroid carcinoma (PTC) has high Ki-67 labeling indices, despite its excellent prognosis. Methods: We examined 21 CMV-PTCs and 5 conventional PTCs (C-PTCs) resected at Kuma Hospital between 2008 2018. All patients with CMV-PTC were women. Their ages ranged from 17 35 years, a mean 25.2 years. An immunohistochemical using β-catenin, estrogen receptor (ER), was performed. For apoptotic analysis,...
Background: The preoperative diagnosis of thyroid follicular carcinomas (FCs) by fine-needle aspiration cytology is almost impossible. It was previously demonstrated that p53-binding protein 1 (53BP1) expression, based on immunofluorescence (IF), can serve as a valuable biomarker to estimate the malignant potential various cancers. 53BP1 belongs class DNA damage response molecules rapidly localize site double-strand breaks, forming nuclear foci (NF). This study aimed elucidate utility NF...
Mutations in ITPR1 cause ataxia and aniridia individuals with Gillespie syndrome (GLSP). However, the pathogenic mechanisms underlying remain unclear. We identified a de novo GLSP mutation hotspot 3'-region of five GLSP. Furthermore, RNA-sequencing immunoblotting revealed an eye-specific transcript Itpr1, encoding 218amino acid isoform. This isoform is localized not only endoplasmic reticulum, but also nuclear cytoplasmic membranes. Ocular-specific transcription was repressed by SOX9 induced...
Thyroid follicular-patterned tumors (TFTs) showing nodule-in-nodule (NN) appearance with poorly differentiated component (PDc) but neither invasion nor metastasis are diagnosed as benign nodules. Although PDc exhibits histologically aggressive features relative to the outer nodule (Out-N), its pathological significance remains unclear. TP53 binding protein-1 (53BP1) is a DNA damage response (DDR) molecule that rapidly localizes at double-strand breaks. Using dual-color immunofluorescence...
Oncocytic follicular adenomas (FAs) of the thyroid are neoplasms cell origin that predominantly composed large polygonal cells with eosinophilic and granular cytoplasm. However, pathological characteristics these tumors largely unexplored. Both initiation progression cancer can be caused by an accumulation genetic mutations induce genomic instability. Thus, aim this study was to evaluate extent instability in oncocytic FA. As presence p53-binding protein 1 (53BP1) nuclear foci has been found...
Abstract Childhood radiation exposure is a known thyroid cancer risk factor. This study evaluated the effects of age on radiation-induced carcinogenesis in rats irradiated with 8 Gy X-rays. We analyzed cell proliferation, death, DNA damage response, and autophagy-related markers 4-week-old (4W) 7-month-old (7M) incidence tumors 4W, 4-month-old (4M), 7M 18 months after irradiation. Cell death response were increased 4W compared to those controls at 1 month post-irradiation. More...
Objective Risk for developing papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be mediated by lifestyle, environmental exposures and genetic factors. Recent progress in genome-wide association studies of cancer leads identification several variants conferring risk this malignancy across different ethnicities. We set out elucidate impact selected single nucleotide polymorphisms (SNPs) on PTC evaluate clinicopathological correlations these Kazakh...
The coexistence of v-Raf murine sarcoma viral oncogene homolog B1 (
A subset of oropharyngeal squamous cell carcinoma (OPSCC) is caused by the high-risk human papilloma virus (HPV), which expresses p16
Adolescent and young adult (AYA, 15-39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological molecular features of PTC in AYA compare them those older (≥40 years). This retrospective study enrolled 1,677 diagnosed from January 2018 December 2022, 400 1,277 adults. At time diagnosis, had...