Tomoaki Hirakawa

ORCID: 0000-0001-7393-0135
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About
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Research Areas
  • Ocean Waves and Remote Sensing
  • Ubiquitin and proteasome pathways
  • Plasma Applications and Diagnostics
  • Wave and Wind Energy Systems
  • Polyamine Metabolism and Applications
  • Amino Acid Enzymes and Metabolism
  • Advanced NMR Techniques and Applications
  • Plasma Diagnostics and Applications
  • Nuclear physics research studies
  • Nuclear Receptors and Signaling
  • Radiation Effects in Electronics
  • Pomegranate: compositions and health benefits
  • Embedded Systems and FPGA Design
  • Macrophage Migration Inhibitory Factor
  • Coastal and Marine Dynamics
  • Semiconductor materials and devices
  • Cannabis and Cannabinoid Research
  • Luminescence Properties of Advanced Materials
  • Endoplasmic Reticulum Stress and Disease
  • Protein Hydrolysis and Bioactive Peptides
  • Aquatic and Environmental Studies
  • Nonlinear Waves and Solitons
  • Nonlinear Photonic Systems
  • Quantum Chromodynamics and Particle Interactions
  • Fluid Dynamics Simulations and Interactions

Kagoshima University
2023-2025

Saga University
2002-2025

Akita University
2023

Kyushu University
2002-2018

The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain proteostasis. When proteasome is dysfunctional, cells compensate for impaired clearance by activating aggrephagy, a type selective autophagy, to eliminate ubiquitinated aggregates; however, molecular mechanisms which function activates aggrephagy remain poorly understood. Here, we demonstrate activation transcriptionally induced transcription...

10.1038/s41598-023-41492-9 article EN cc-by Scientific Reports 2023-09-01

Abstract Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e. polyamine overload, oxidative stress, aging, infection, etc.) triggers catabolic conversion spermine to ultimately yielding acrolein hydrogen peroxide. potential induce DNA damage protein denaturation is 1,000 times greater than that...

10.1038/s41598-025-96388-7 article EN cc-by Scientific Reports 2025-04-21

After decades of research and development, plasma displays are finally beginning to appear in the commercial consumer markets. Following a short review on basic principles direct alternating current displays, we present summary status color displays. Plasma display panels (PDPs) have achieved luminance efficiency values par with hi-definition cathode ray tube monitors. Additional improvements performance will open up new world large PDP Ultimately, what drive market be continued PDPs...

10.1109/jproc.2002.1002525 article EN Proceedings of the IEEE 2002-04-01

Abstract The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain proteostasis. When proteasome is dysfunctional, cells compensate for impaired clearance by activating aggrephagy, a type selective autophagy, to eliminate ubiquitinated aggregates; however, molecular mechanisms which function activates aggrephagy remain poorly understood. Here, we demonstrate activation transcriptionally induced...

10.21203/rs.3.rs-3045339/v1 preprint EN cc-by Research Square (Research Square) 2023-06-19

Fibrosis is a major problem in chronic liver disease with limited treatment options due to its complex nature. Herbal medicines are often used as an alternative. The aim of this study was investigate the therapeutic potential Osbeckia octandra and identify active compounds regulatory pathways. effects crude leaf suspension boiled extract were investigated animal model, found be more effective treatment. Three bioactive compounds, pedunculagin, casuarinin, gallic acid, isolated from using...

10.1093/bbb/zbad114 article EN Bioscience Biotechnology and Biochemistry 2023-08-14

<title>Abstract</title> Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e. polyamine overload, oxidative stress, aging, etc.) triggers catabolic conversion spermine to ultimately yielding acrolein hydrogen peroxide. potential induce DNA damage protein denaturation is 1,000 times greater than...

10.21203/rs.3.rs-5344132/v1 preprint EN cc-by Research Square (Research Square) 2024-12-05

After the disaster in Tohoku region of Japan, as a part recovery projects, wave energy has been drawing attention. To promote technologies, including converters (WECs), this study aims to present comprehensive analyses climates around Kyushu, which is southernmost and third largest Japan's four main islands. This paper calculates climate Kyushu for ten years (2007–2016) using Simulating WAves Nearshore model with an approximately 800 m high spatial 1-h temporal resolution. The results reveal...

10.1063/1.5011431 article EN Journal of Renewable and Sustainable Energy 2018-03-01

We directly calculate fully nonlinear traveling waves that are periodic in two independent horizontal directions (biperiodic) shallow water.Based on the Riemann theta function, we also exact solutions to Kadomtsev-Petviashvili (KP) equation, which can be obtained by assuming weakly-nonlinear, weakly-dispersive, weakly-two-dimensional waves.To clarify how accuracy of biperiodic KP solution is affected when some approximations not satisfied, compare fully-and weakly-nonlinear various wave...

10.1088/1873-7005/aa9e99 article EN Fluid Dynamics Research 2017-12-01

After the principle of DC and AC plasma displays are explained, brief history research development color described. The reasons why surface-discharge has survived is also described concerning specific performance. next generation discussed for coming era display TV.

10.1109/ias.2003.1257481 article EN 2004-01-23
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