A5066572835- Ion channel regulation and function
- Cellular Mechanics and Interactions
- Erythrocyte Function and Pathophysiology
- Trace Elements in Health
- Bone health and osteoporosis research
Indiana University Indianapolis
2022-2024
Indiana University – Purdue University Indianapolis
2022-2024
Indiana University Health
2024
Abstract Osteocytes sense and respond to mechanical force by controlling the activity of other bone cells. However, mechanisms which osteocytes input transmit biological signals remain unclear. Voltage-sensitive calcium channels (VSCCs) regulate (Ca2+) influx in response external stimuli. Inhibition or deletion VSCCs impairs osteogenesis skeletal responses loading. VSCC is influenced its auxiliary subunits, bind channel’s α1 pore-forming subunit alter intracellular Ca2+ concentrations. The...
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning pericellular space osteocytes transmitting mechanical information into biochemical signals. While we heparan sulfate proteoglycan perlecan (PLN) as a component these TEs, PLN must attach to cell surface induce responses. As voltage-sensitive calcium channels (VSCCs) are critical for bone mechanotransduction,...
Abstract Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning pericellular space osteocytes transmitting mechanical information into biochemical signals. While we heparan sulfate proteoglycan perlecan (PLN) as a component these TEs, PLN must attach to cell surface induce responses. As voltage-sensitive calcium channels (VSCCs) are critical for bone...