A5058701562- Anesthesia and Sedative Agents
- Veterinary Pharmacology and Anesthesia
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
Poznan University of Medical Sciences
2014-2020
The purpose of this study was to assess the pharmacokinetics dexmedetomidine in ICU settings during prolonged infusion and compare it with existing literature data using Bayesian population modeling literature-based informative priors. Thirty-eight patients were included analysis concentration measurements obtained at two occasions: first from 0 24 h after initiation second 8 end. Data conducted WinBUGS software. prior information on elicited pooling results a relatively large group 95...
Aim: The purpose of this work was to develop and validate a rapid robust LC–MS/MS method for the determination dexmedetomidine (DEX) in plasma, suitable analysis large number samples. Method: Systematic approach, Design Experiments, applied optimize ESI source parameters evaluate robustness, therefore, rapid, stable cost-effective assay developed. validated according US FDA guidelines. LLOQ determined at 5 pg/ml. linear over examined concentration range (5–2500 pg/ml), Results: Experimental...
Dexmedetomidine (DEX) is a fairly new alfa2-agonist which has been increasingly used in recent years for analgosedation, mostly because it offers unique ability of providing both moderate level sedation and analgesia without respiratory depression. Despite many papers published, there are still only few concerning the PK drug given as long-term infusion ICU patients. The aim this work was to characterize population pharmacokinetics dexmedetomidine investigate potential benefits...
The aim of this study was to develop a population pharmacokinetic model sufentanil and assess the influence covariates in critically ill children admitted pediatric intensive care unit. After institutional approval, 41 were enrolled study. Blood samples for (PK) assessment collected from routinely placed arterial catheters during after discontinuation infusion. Population nonlinear mixed-effects modeling performed using NONMEM. A 2-compartment described PK sufficiently. Typical values...
Aim. This study aimed to examine the influence of maturation and dosage on sedative haemodynamic response observed in rabbits after administration dexmedetomidine. Material methods. The pharmacodynamics dexmedetomidine was studied 14 healthy New Zealand white at three periods maturation; stage 1–1.5 months old, 2–2.5 old 3–6.5 ones. administered dose ranged from 25 µg/kg 300 body weight. pedal withdrawal reflex used measure duration anaesthesia. heart rate mean arterial pressure were...
Abstract The purpose of this work was i) to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model dexmedetomidine (DEX) in New Zealand White rabbits, ii) investigate the influence age weight animals on parameters, iii) assess linearity DEX PKs examined dose range. This prospective, crossover study, using total 18 rabbits. administered as single intravenous bolus injection doses from 25 300 μg kg −1 . Each rabbit given same drug its three developmental stages. To determine...