A5030809281- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neuropeptides and Animal Physiology
- EEG and Brain-Computer Interfaces
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Atomic and Subatomic Physics Research
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Neonatal and fetal brain pathology
- Monoclonal and Polyclonal Antibodies Research
- Blood Coagulation and Thrombosis Mechanisms
- Glycosylation and Glycoproteins Research
- Biochemical and Structural Characterization
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Pharmacological Receptor Mechanisms and Effects
- Biochemical effects in animals
- Medical Imaging and Pathology Studies
- Erythrocyte Function and Pathophysiology
- Pain Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
Boston Children's Hospital
2015-2025
Harvard University
2015-2025
Athinoula A. Martinos Center for Biomedical Imaging
2024-2025
Massachusetts General Hospital
2024-2025
Matsuyama Red Cross Hospital
2025
Aalto University
2022
Kobe Gakuin University
2005-2017
Osaka University
1974-2010
University of New Mexico
2000-2009
Imaging Center
2005-2009
A realistically shaped three-dimensional single-neuron model was constructed for each of four principal cell types in the neocortex order to infer their contributions magnetoencephalography (MEG) and electroencephalography (EEG) signals. For cell, soma stimulated resulting intracellular current used compute dipole Q whole or separately apical basal dendrites. The magnitude is proportional magnetic field electrical potential far from neuron. train spikes depolarization shift an burst...
Following the rapid progress in development of optically pumped magnetometer (OPM) technology for measurement magnetic fields femtotesla range, a successful assembly individual sensors into an array nearly identical is within reach. Here, 25 microfabricated OPMs with footprints 1 cm(3) were assembled conformal array. The inserted three flexible belt-shaped holders and connected to their respective light sources electronics, which reside outside magnetically shielded room, through long...
Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about functional and structural changes this disorder developing brain. Here, investigated with three different neuroimaging modalities [magnetoencephalography (MEG), diffusion tensor imaging (DTI), resting-state fMRI] whether spastic CP associated anatomical abnormalities sensorimotor network. Ten children participated study: four diplegic (DCP), hemiplegic (HCP), typically...
This study evaluated the role of excitatory amino acid (EAA) receptor activation in spreading depression (SD), using vitro turtle cerebellum as a model system. SD was triggered by electrical stimulation or elevated K+ after had been conditioned for at least 30 min with physiological saline which most chloride replaced propionate. recognized transient (1–3 min) negative shift extracellular potential accompanied evoked potentials (15–30 and an increase up to 60 mM, spread across rates 1–7...
We introduce an anatomical and electrophysiological model of deep brain structures dedicated to magnetoencephalography (MEG) electroencephalography (EEG) source imaging. So far, most imaging inverse models considered that MEG/EEG surface signals were predominantly produced by cortical, hence superficial, neural currents. Here we question whether crucial such as the basal ganglia hippocampus may also contribute distant, scalp MEG EEG measurements. first design a realistic these subsequently...
Mu rhythm is an idling that originates in the sensorimotor cortex during rest. The frequency of mu rhythm, which well established adults, 8–12 Hz, whereas limited results available from children suggest a as low 5.4 Hz at 6 months age, gradually increases to adult value. Understanding normal development has important theoretical and clinical implications since we still know very little about this signal infants how it develops with age. We measured over left hemisphere using pediatric...
We developed a 375-channel, whole-head magnetoencephalography (MEG) system (“BabyMEG”) for studying the electrophysiological development of human brain during first years life. The helmet accommodates heads up to 95% 36-month old boys in USA. unique two-layer sensor array consists of: (1) 270 magnetometers (10 mm diameter, ∼15 coil-to-coil spacing) inner layer, (2) thirty-five three-axis (20 × 20 mm) outer layer 4 cm away from layer. Additionally, there are three reference magnetometers....
We show that it is feasible to monitor the synchronized population spikes of thalamocortical axonal terminals and cortical neurons outside brain using high-resolution magnetoencephalography (MEG). Electrical stimulation snout elicited somatic-evoked magnetic fields (SEFs) above primary somatosensory cortex (SI) piglet. The SEFs contained high-frequency oscillations (HFOs) around 600 Hz similar in many respects noninvasively measured HFOs from humans with MEG electroencephalography (EEG)....
Recently Okada et al. (1981) reported that stimulation of the median nerve with a brief electrical impulse at wrist evoked transient change in brain's magnetic field. This somatic field (SEF) is similar its temporal waveform to response same stimulus for potential recorded on pial surface exposed brain. Moreover, both measures differ substantially from (SEP) scalp. The present paper describes more detailed account SEF as well an analysis relation SEP and (SPR). Its purpose use three...
Multichannel Transcranial Magnetic Stimulation (mTMS) arrays enable multiple sites to be stimulated simultaneously or sequentially under electronic control without moving the system's stimulation coils. Here, we build and characterize performance of a novel modular 3-axis TMS coil that can utilized as unit element in large-scale multichannel arrays. We determined basic physical characteristics x-, y- z-elements using custom 2-channel programmable stimulator prototype. mapped temporal...
Regional blood flow in the liver, pancreas and kidney was measured under conditions of profound hypothermia associated with total circulatory arrest, to determine whether cardiopulmonary bypass pulsatile would improve these visceral organs comparison nonpulsatile flow. Using 56 adult mongrel dogs, carried out induce 40 min arrest performed at 20 degrees C. After temperature raised 35 With flow, a decrease regional prevented during cooling, especially C before arrest. Moreover, renal...