A5058277737- Orthopaedic implants and arthroplasty
- Hemoglobinopathies and Related Disorders
- Bone Tissue Engineering Materials
- Various Chemistry Research Topics
- Innovative Teaching Methods
- Metal and Thin Film Mechanics
- Tuberculosis Research and Epidemiology
- Science Education and Pedagogy
- Brain Metastases and Treatment
- Pharmacological Effects and Toxicity Studies
- Electrophoretic Deposition in Materials Science
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Treatment and Pharmacology
- Advanced materials and composites
- Infectious Encephalopathies and Encephalitis
- Iron Metabolism and Disorders
- Orthopedic Infections and Treatments
- Tribology and Wear Analysis
- Glioma Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
Rush University Medical Center
2024
University of Pittsburgh Medical Center
2023
University of Jordan
2019-2021
University of Illinois Chicago
2016-2017
While titanium nitride (TiN) coatings are well known for their biocompatibility and excellent mechanical properties, wear particle debris release in orthopedic implants remains a matter of active investigation. This study addresses the efficacy TiN on CoCrMo Ti6Al4V alloys to enhance resistance reduce ion from prosthetic implants. Three different coating variants were utilized: one variant deposited using arc evaporation (Arc) followed by post-treatment, two high-power impulse magnetron...
An understanding of protein folding relies on a solid foundation number critical chemical concepts, such as molecular structure, intra-/intermolecular interactions, and relating structure to function. Recent reports show that students struggle all levels achieve these understandings use them in meaningful ways. Further, several the visualization techniques employed help understand often lead confusion propagate further misconceptions. Here, we report lab exercise using computer-based...
Introductory Chemistry laboratories must go beyond “cookbook” methods to illustrate how chemistry concepts apply complex, real-world problems. In our case, we are preparing students use their knowledge in the healthcare profession. The experiment described here explicitly models three important chemical concepts: dialysis of small molecules (dye), reversible binding (dye albumin), and competitive a competitor albumin). Moreover, each concept is intimately related physiological phenomenon:...
Abstract Cisplatin, a platinum-based drug, is one of the oldest and most widely used chemotherapeutic agents. It exerts its anti-tumor effect by forming DNA inter-strand intra-strand cross-links, resulting in lesions that eventually activate apoptotic pathways. Cisplatin remains for treatment several solid tumors, though this often limited toxicity which can affect many organ systems, including nephrotoxicity, hepatotoxicity, ototoxicity, neurotoxicity. A dose-dependent peripheral sensory...
We created TiO 2 nanotubes (TNTs) on the surface of titanium (Ti) implants with subsequential loading gentamicin and chitosan, acting as a control release agent, by electrophoretic deposition (EPD). hypothesized femoral TNTs loaded chitosan would localize antibiotic to implant surgical site prevent PJI in mouse model. Ti-6Al-4V ELI wires underwent TNT modification two-step anodization. EPD was then used load onto Ti wire TNTs. Control contained only. 12-week-old male C57BL/6J mice received...
ABSTRACT Periprosthetic joint infection (PJI) is a leading cause and major complication of replacement failure. As opposed to standard‐of‐care systemic antibiotic prophylaxis for PJI, we developed tested titanium femoral intramedullary implants with titania nanotubes (TNTs) coated the gentamicin slow‐release agent chitosan through electrophoretic deposition (EPD) in mouse model PJI. We hypothesized that these would enable local delivery implant surface surgical site, effectively preventing...