The disassembly and reorganization of sperm-derived structures are landmarks for the onset embryonic development. Since complete information on these events is not yet available, we examined sperm axoneme, formation aster, decondensation development male female pronuclel in inseminated Rhesus monkey oocytes conceived by in-vitro fertilization (IVF) or intracytoplassnic injection. During IVF, spermatozoa lose their acrosomes after contacting zona pellucida, plasma membrane nuclear envelope...

Abstract Few studies compare HRQOL and PSA in children who have undergone different types of solid organ Tx. In this cross‐sectional study, were assessed 74 Tx patients (16 heart, 44 kidney, 14 liver) at a mean age 11.5 (range 6.3–16.7), 7.2 yr post‐Tx 1.0–15.0). was self‐assessed using standardized health utility questionnaires (15D–17D). The patients' evaluated the Child Behavior Checklist for parents, Youth Self‐Report aged 11–16 yr, Teacher Report Form. Outcomes did not differ...

BACKGROUND Infertility, poor semen quality, and gonadal dysfunction are well recognized long‐term sequelae in male survivors of childhood acute lymphoblastic leukemia (ALL). However, few studies have investigated adult sexual functioning these survivors. METHODS The authors studied 52 ALL at a median age 28.5 years (range, 25‐38 years) ≥ 10 after diagnosis. In addition, 56 men without history cancer were recruited for an age‐matched control group. participants completed the Derogatis...

Endocrine complications are a common late effect after childhood cancer. Our study assessed the prevalence and predictors of premature ovarian insufficiency (POI) prospects pregnancy in young female survivors. This nationwide combined registry survey data for cancer survivors aged 19 to 40 years, identified through National Quality Registry Childhood Cancer Sweden. Of 1989 approached women, 1333 (67%) participated by completing survey. Median age at diagnosis 1981 2017 was 6 (range 0-17) 28...

Varying results on the cognitive outcome of children who have undergone kidney transplantation (KTx) raised concern for specific neurocognitive difficulties. Fifty with KTx were assessed at a mean age 11.1 (SD 3.2; range 6.3–16.4), average 6.9 3.6; 1.0–14.1) years post-operatively. A standardized test intelligence [Wechsler Intelligence Scale Children (WISC-III)] and neuropsychological tests from NEPSY-II administered. The profile was compared to that control group matched gender, maternal...

Abstract Aim Studies examining the long‐term effects of neonatal music interventions on cognition children born preterm are scarce. We investigated whether a parental singing intervention before term age improves cognitive and language skills in preterm‐born children. Methods In this longitudinal, two‐country Singing Kangaroo, randomised controlled trial, 74 infants were allocated to or control group. A certified therapist supported parents 48 group sing hum during daily skin‐to‐skin care...

There are few studies assessing long-term adult outcome and health-related quality of life (HRQOL) in former pediatric high-risk kidney transplant (TX) recipients.Twenty-one patients were assessed at mean age 21.1 years. Mean first TX was 2.4 Brain arterial border zone infarcts had been documented 54% the children. HRQOL with general 15-dimensional (15D) instrument generating an index on a 0 1 scale (1 for best). The results compared corresponding childhood 17-dimensional control group from...

Children's language background relates to their neurocognitive development. Knowledge of this relationship is important as bilingualism common. However, research regarding in relation performance on cognitive tests such the WPPSI‐IV and NEPSY‐II scarce. The present study compared performances between 5‐ 6‐year‐old Swedish‐speaking monolingual ( n = 45) Swedish‐Finnish‐speaking simultaneous bilingual 34) children Finland. participants were gathered by stratified sampling assessed with Swedish...

Abstract Childhood cancer survivors are at risk of various endocrine late effects affecting their quality life. The aim this study was to assess the prevalence and predictors reproductive outcomes in young adult survivors. A secondary possible associations between testosterone replacement therapy (TRT) other endocrine, cardiovascular psychosocial effects. This nationwide comprised 1212 male childhood aged 19–40 years, identified through National Quality Registry for Cancer Sweden. Median age...

International guidelines highlight the importance of using appropriate and culturally fair test materials when conducting clinical psychological assessments. In present study, generalizability Swedish WISC-V with Scandinavian normative data was explored in 6–16-year-old Swedish-speaking children Finland (N = 134), as no local versions or norms are available for this minority. First, metric measurement invariance established, i.e., constructs measured were equivalent between standardization...

A minority of children with liver transplants exhibit significant delay in global intelligence; others have specific learning disabilities. More data on neurocognitive strengths and weaknesses are lacking. Eighteen aged 7-16 yr, who had undergone LTx Finland participated the study. They were assessed an average 7.6 (s.d. 4.5, range 1.0-15.0) years post-operatively at a mean age 11.8 3.1, 7.2-16.1). standardized test intelligence (WISC-III), neuropsychological battery (NEPSY-II), parental...

To analyze physical fitness, activity and the prevalence of frailty in male long-term survivors pediatric allogeneic hematopoietic stem cell transplantation (HSCT). We performed a Nordic two-center study 98 (mean age 28.7 years, range 18.5-47.0) treated with (HSCT) 1980-2010 denmark or finland. fitness was evaluated by dominant hand grip-strength, timed up-and-go, sit-to-stand, gait speed two-minute walk tests.Survivors presented significantly lower muscle strength endurance hand-grip...

There are many known endocrine complications after allogeneic hematopoietic stem cell transplantation (HSCT) in childhood including increased risk of biochemical hypogonadism. However, little is about sexuality adulthood following HSCT. In this multicenter study, sexual functions and possible factors were assessed comprehensively two national cohorts (Finland Denmark) male adult survivors Compared to a healthy control group (n = 56), HSCT 97) reported less fantasies, poorer orgasms, lower...

The Wechsler scales are among the most widely used tests in cognitive and neuropsychological assessments. When assessing children aged 6:0–7:7 years clinician can choose between Preschool Primary Scale of Intelligence – Fourth Edition (WPPSI-IV) for Children Fifth (WISC-V). Information about how function differ this overlapping age range is limited. Using a between-subjects design, present study compared profiles typically developing Swedish-speaking Finland (6:1 7:2 years), assessed with...

This study determined the cognitive outcomes of Finnish children born with an extremely low birth weight (ELBW) and assessed agreement between their neuropsychological assessment how parents evaluated difficulties.The focused on 121 from ELBW cohort a mean age 11.6 years (range 10.3-13.8) them using standardised test intelligence, battery parental developmental questionnaire. The results were compared norms.ELBW exhibited global impairment to norms, no differences who small or appropriate...

Abstract This study was conducted to evaluate the long‐term prognosis of pediatric HT x patients treated with VAD before transplantation. The clinical data six bridged Berlin Heart EXCOR device were analyzed retrospectively. Information about graft function, CA results, and EMB findings as well appearance DSA collected. Also, information growth cognitive function analyzed. These compared age‐, gender‐, diagnosis‐matched patients. During median follow‐up time four half yr after x, including...

Abstract Objective: The Swedish Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) is commonly used for assessing young children belonging to the Swedish-speaking minority in Finland (Finland-Swedes), but there no information about generalizability this test its norms minority. Cross-cultural comparisons WPPSI-IV are also scarce. We compared performance Finland-Swedish Scandinavian explored relationship between sociodemographic factors (age, sex, parental education level,...

While it has been established that cultural differences in test performance are common, few studies have compared groups from different countries speak the same language. The aim of this study was to investigate generalizability selected linguistic and verbal memory subtests Swedish NEPSY-II Finland-Swedish minority group. participants were 275 Swedish-speaking children Finland aged 5–16-years. U.S. norms used test. scored around scaled score 12 significantly higher than normative mean on...

Abstract Childhood cancer treatments predispose to late health problems and premature death. Our aim was use national registry data study associations between therapy exposures outcomes in aging male childhood survivors (CCS). The comprised 200 CCS (survival ≥5 years) treated with conventional at a single institution 1964–2000 1000 matched population controls. Analyses involved registry‐based on prescription drug purchases, reimbursements for chronic conditions, hospital admissions, deaths...

Background Recent longitudinal studies suggest stable cognitive development in preterm children, although with great individual variation. This prospective neurocognitive follow-up study of extremely low birthweight (ELBW, <1000 g) children aimed to characterise groups different developmental trajectories from preschool preteen age. Methods ELBW (n=115) born Finland 1996–1997 participated assessments at a median age 5.0 years and 11.3 years. A standardised test intelligence (Wechsler...