A5015720458- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Nonmelanoma Skin Cancer Studies
- Celiac Disease Research and Management
- Lung Cancer Research Studies
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Metastasis and carcinoma case studies
- Gastroesophageal reflux and treatments
- Infectious Diseases and Mycology
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Photodynamic Therapy Research Studies
- Meningioma and schwannoma management
- Renal cell carcinoma treatment
- Digestive system and related health
- Brain Metastases and Treatment
- Breast Lesions and Carcinomas
- Cytomegalovirus and herpesvirus research
- Glioma Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
St Olav's University Hospital
2016-2025
Norwegian University of Science and Technology
2016-2025
Medical Genetics Center
2011
Coeliac disease (CD) is a common disorder and affects about 1% of the population worldwide. CD in Trøndelag Health Study (HUNT) population-based cohort study which was established to provide new knowledge that can improve diagnostics management, prevent onset or progression expand role genetics disease.
The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features positive staining for antibodies differentiation. Neuron-specific enolase (NSE) being a cytosolic marker useful in this setting. NSE by many considered nonspecific, due to the finding tumors not origin. Our aim was determine whether true more specific than previously realized. We examined 178 (carcinomas NENs) from breast, lung, stomach, kidney using immunohistochemistry with...
Background Topical photodynamic therapy (PDT) is an approved and widely used treatment for low-risk basal cell carcinoma (BCC), comprising two sessions with interval of 1 week. Simplification the course can be cost-effective, easier to organize, cause less discomfort patients. Methods findings We performed investigator-initiated, single-blind, non-inferiority, randomized controlled multicentre study objective investigating whether a simpler more flexible PDT regimen was not >10% effective...
A family with a missense variant of the ATP4A gene encoding alpha subunit gastric proton pump (H + K ATPase) has recently been described. Homozygous siblings were hypergastrinemic (median gastrin 486 pM) and had tumours diagnosed at median age 33 years. In current histopathological study, we further characterized found in corpus. The histological appearance carcinoids (NET G1 or G2) immunoreactive for general neuroendocrine markers chromogranin (CgA) synaptophysin as well ECL‐cell vesicular...
ObjectiveCurrently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts been made to overcome these barriers by targeting the tumor microenvironment. Results so far are promising, but without clinical impact. Our aim was investigate whether ultrasound and microbubbles could improve uptake therapeutic response of conventional chemotherapy.MethodsOrthotopic tumors growing in mice were treated...
Perioperative chemotherapy has become standard care for resectable gastric cancer. However, available evidence is based on a limited number of trials, and the outcomes in routine clinical practice unselected patients are scarcely reported.The study included consecutive series with cancer treated between 2001 2011 Central Norway. Before 2007, did not receive perioperative chemotherapy. Since medically fit aged 75 years or less have been offered this. Response rates were evaluated by CT,...
Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late course, and of patients die within a few years diagnosis. In addition Helicobacter pylori gastritis, gastrin considered factor development this disease, thus, cholecystokinin-B receptor (CCKBR) becomes interest. The aim our study was explore whether CCKBR expressed stomach cancers. Thirty-seven tumors from 19 men 18 women diagnosed with either adenocarcinoma or...
Background A large proportion of individuals with coeliac disease (CeD) remain undiagnosed. Objective The aim this study was to assess serological screening for CeD in the adult general population. Design based on fourth Trøndelag Health Study, a population-based performed 2017–2019 Nord-Trøndelag County, Norway, including 56 042 participants >20 years age (54% participation rate). Serum samples were analysed dual antitransglutaminase 2 (TG2) IgA and IgG assay seropositive invited...
Abstract Deletion in 22q and mutations the neurofibromatosis type 2 (NF2) gene are frequent sporadic meningiomas. The tumor suppressor protein merlin is encoded by NF2, may promote development. NF2 status increasingly important meningioma diagnostics we questioned whether immunohistochemistry could be used as an accessible affordable surrogate marker for prediction of mutations. Previous studies on immunoreactivity have reported diverging results. We aimed to describe immunohistochemical...
Population-based studies for gastric adenocarcinoma are scarce, particularly conducted within a defined geographical area with publicly available censuses that allow incidence rates to be calculated.Population-based study in Central Norway from 2001 2011, covering population of 636 000-680 000, respectively. Patients were identified through the Cancer Registry and Norwegian Patient Register, characterized by data individual electronic patient records. Outcomes compared across early late half...
Meningioma is the most frequent brain tumor, and incidence ever-increasing. Though often benign slow growth, recurrence rates are substantial today's surgical radiation-based treatment not without complications. No drugs specific for meningiomas hitherto approved patients with inoperable or recurrent meningioma left few options. Somatostatin receptors previously detected in may inhibit growth when stimulated by somatostatin. Hence, somatostatin analogs could provide a targeted drug therapy....
The aim of the study was to investigate expression erythropoietin and neuroendocrine markers in clear cell renal carcinoma ( CCRCC ). We retrospectively reviewed medical records re‐evaluated histopathological specimens 33 patients with compared those 11 cases non‐ . All were treated a partial or radical nephrectomy at St. Olavs Hospital, Trondheim University between 2010 2016. Thirty‐three who diagnosed had total 35 tumours, where 34 tumours one papillary adenoma. (97%) s positive for...
Small intestinal neuroendocrine tumors (SI-NETs) are slow growing but have frequently metastasized at the time of diagnosis. Most patients operated with either curative intent or to prolong overall survival. In current study we examined and disease-free survival in for SI-NETs. All a histological diagnosis SI-NET St Olav's hospital period 1998–2018 were reviewed retrospectively. Patient, disease treatment characteristics including European Neuroendocrine Tumor Society (ENETS) TNM staging...
Photodynamic therapy is an approved treatment for primary, superficial, and small nodular basal cell carcinomas with a thickness of < 2 mm located on low-risk sites. Histologically verified clinically assessed as suited photodynamic were included. The study aimed to investigate the agreement between clinical histological assessments carcinoma subtypes tumours selected histopathological evaluation reference. A total 343 diagnosis subtype was 72% (p 0.001). Clinical assessment had...
The aim of the present study was to develop and clinically validate a high-throughput assay for serum IgA IgG antibodies against transglutaminase-2 (TG2) determine appropriate cut-offs large-scale population screening celiac disease. An automated method developed using dual label time-resolved fluorometry on AutoDELFIA platform. Individuals (n = 1920) from general were screened. Subjects with anti-TG2 concentrations above preliminary cut-off (>0.3 mg*/L or >0.5 IgG) offered endoscopic...
Tumour thickness affects the outcome of photodynamic therapy in basal cell carcinoma (BCC). The aim this study was to evaluate whether punch biopsy provides reliable information on BCC tumour thickness, by comparing corresponding measurements and excision specimens for 48 lesions 43 patients. tumours were between 0.2 6.1 mm thick. mean depth excisions 0.14 greater than that biopsies. Bland-Altman 95% limits agreement (-1.3, 1.6) mm, but difference increased with thickness. A 1.0 yielded an...
Abstract Objectives To evaluate the outcomes among patients treated for gastric adenocarcinoma in a referral hospital, and to identify possible trends during last decade. Methods All evaluated period 1999–2009 were included. Results Of 397 patients, 52% curatively resected. Crude 5‐year survival first 6 years was 38.7% (CI 29.5–47.9), 5 years, 49.2% 38.8–59.6). Time ( P = 0.013), age < 0.001) disease stage 0.001), significant predictors of long‐term rates. Among resected, in‐hospital...
The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the stomach. aim our study was therefore to assess if associated with an increased risk developing also humans. A prospective population-based nested case-control within Nord-Trøndelag Health Study (HUNT) cohort, Norway, used this association. Serum collected from 78 962 participants 1995 1997 and 2006 2008. In 181 incident cases were...
Objectives: To review the presentation, treatment and outcome of patients with type 1 gastric carcinoid tumours.Material methods: We retrospectively reviewed medical records re-evaluated histopathological specimens 26 carcinoids treated at a single tertiary referral centre from 1993 to 2013, median time follow-up 52.5 months (IQR 90.8).Results: Seven (27%) had tumours 19 (73%) multiple diagnosis. The number diameter largest tumour were 2.5 3.2) 6.0 mm 9.5) respectively. Median serum gastrin...