A5012464626- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Endoplasmic Reticulum Stress and Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Kruppel-like factors research
- Cancer Risks and Factors
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Acute Myeloid Leukemia Research
- Colorectal Cancer Surgical Treatments
- Estrogen and related hormone effects
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Cancer-related gene regulation
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
Royal Brisbane and Women's Hospital
2025
The University of Queensland
2020-2025
Queensland University of Technology
2020
QIMR Berghofer Medical Research Institute
2014-2018
Endometrial cancer (EC) is the fifth most common in women worldwide. Global estimates show rising incidence rates both developed and developing countries. Most are diagnosed postmenopausal, but 14-25% of patients premenopausal 5% under 40 years age. Established risk factors include age hyperestrogenic status associated with nulliparity, obesity, metabolic syndrome. Standard treatment for EC, which involves total hysterectomy bilateral salpingo-oophorectomy, has excellent survival outcomes,...
Rationale: Epigenetic mechanisms are fundamental processes that can modulate gene expression, allowing cellular adaptation to environmental conditions. Hypoxia is an important factor known initiate the metastatic cascade in cancer, activating cell motility and invasion by silencing adhesion genes. G9a a histone methyltransferase previously shown accumulate hypoxic While its oncogenic activity has been reported, not much about role plays hypoxia-mediated cascade. Methods: The of condition was...
Background Sentinel node biopsy is a surgical technique to explore lymph nodes for staging of endometrial cancer, which has replaced full retroperitoneal dissection. However, the effectiveness sentinel biopsy, its value patients, and potential harms compared with no-node dissection have never been shown in randomized trial. Primary Objectives Stage 1 will test recovery from surgery. 2 compare disease-free survival at 4.5 years between patients versus no Study Hypothesis The primary...
The standard treatment for endometrial cancer is hysterectomy with or without bilateral salpingo-oophorectomy; however, this may not be an optimal choice women who have completed childbearing are at a high risk of surgical complications. Conservative levonorgestrel intrauterine devices appear to effective in patients early-stage cancer; mismatch repair-deficient (dMMR) tumors low likelihood responding devices. To assess the efficacy dostarlimab, active immune checkpoint inhibitor that...
Many women who develop endometrial cancer (EC) or hyperplasia with atypia are obese and therefore at high risk of surgical complications. Recently clinical trials have been initiated offering non-surgical treatment to these women, but not all may agree participate in such trials. This paper aims describe the patient characteristics, outcomes suspected early stage body mass index (BMI) 30 greater, declined enrolment feMMe trial, which offers hormonal treatment, plus metformin weight loss as...
Up to 80% of endometrial and breast cancers express oestrogen receptor alpha (ERα). Unlike cancer, anti-oestrogen therapy has had limited success in raising the possibility that different effects both cancers. We investigated role using data from The Cancer Genome Atlas (TCGA) conjunction with cell line studies. Using phosphorylation ERα (ERα-pSer118) as a marker transcriptional activation TCGA datasets, we found genes associated ERα-pSer118 were predominantly unique between tumour types...