A5004296173- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Sulfur Compounds in Biology
- Regulation of Appetite and Obesity
- Redox biology and oxidative stress
- Autophagy in Disease and Therapy
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Stress Responses and Cortisol
- Treatment of Major Depression
- Amino Acid Enzymes and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Nicotinic Acetylcholine Receptors Study
- Pancreatic function and diabetes
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Calcium signaling and nucleotide metabolism
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Biological and pharmacological studies of plants
- Sleep and Wakefulness Research
- Molecular Sensors and Ion Detection
Huazhong University of Science and Technology
2013-2024
Shantou University
2022
Second People Hospital of Hunan
2021
Ministry of Education of the People's Republic of China
2009-2020
Yanbian University
2020
The University of Texas MD Anderson Cancer Center
2019
Anhui Medical University
2013
Molina Center for Energy and the Environment
2008
Abstract Melatonin ( N ‐acetyl‐5‐methoxytryptamine) is reported to improve mood disorders in perimenopausal women and gut microbiome composition altered during menopausal period. The possible role of the treatment effect melatonin on depression remains unknown. Here, it shown that reverses microbiota dysbiosis depressive‐like behaviors ovariectomy (OVX) operated mice. This prevented by antibiotic cocktails (ABX) treatment. Transferring harvested from adolescent female mice OVX‐operated...
Activation of central PPARγ promotes food intake and body weight gain; however, the identity neurons that express mediate effect this nuclear receptor on energy homeostasis is unknown. Here, we determined selective ablation in murine proopiomelanocortin (POMC) decreases peroxisome density, elevates reactive oxygen species, induces leptin sensitivity these neurons. Furthermore, POMC preserved interaction between mitochondria endoplasmic reticulum, which dysregulated by HFD. Compared with...
Summary Previous studies have demonstrated that AMP ‐activated protein kinase ( AMPK ) controls autophagy through the mammalian target of rapamycin (mTOR) and Unc‐51 like 1 ULK 1/Atg1) signaling, which augments quality cellular housekeeping, β‐guanidinopropionic acid (β‐ GPA ), a creatine analog, leads to chronic activation . However, relationship between β‐ aging remains elusive. In this study, we hypothesized feeding adult Drosophila produces lifespan extension via ‐dependent autophagy. It...
Recent evidence indicates the existence of a putative novel phosphatidylinositol-linked D1 dopamine receptor in brain that mediates phosphatidylinositol hydrolysis via activation phospholipase Cbeta. The present work was designed to characterize Ca(2+) signals regulated by this D(1) primary cultures hippocampal neurons. results indicated stimulation its newly identified selective agonist SKF83959 induced long-lasting increase basal [Ca(2+)](i) time- and dose-dependent manner. Stimulation...
Deficits in learning and memory accompanied by age-related neurodegenerative diseases are closely related to the impairment of synaptic plasticity. In this study, we investigated role thiol redox status modulation N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) CA1 areas hippocampal slices. Our results demonstrated that impaired LTP induced aging could be reversed acute administration reductants can regulate directly, such as dithiothreitol or β-mercaptoethanol,...
There is growing interest in the physiological functions of flavonoids, especially their effects on cognitive function and neurodegenerative diseases. The aim current investigation was to evaluate role flavonoid baicalein long-term potentiation (LTP) hippocampal CA1 region behavioural performance.Effects LTP rat slices were investigated by electrophysiological methods. Phosphorylation Akt (at Ser(473)), extracellular signal-regulated kinase (ERK1/2) transcription factor cAMP response...
Hypothalamic AMP-activated protein kinase (AMPK) and orexins/hypocretins are both involved in the control of feeding behavior, but little is known about interaction between these two signaling systems. Here, we demonstrated that orexin-A elicited significant activation AMPK arcuate nucleus (ARC) hypothalamus by elevating cytosolic free Ca²⁺ involving extracellular calcium influx. Electrophysiological results revealed increased L-type current via orexin receptor-phospholipase C-protein C...
Methionine (Met) sulfoxide reductase A (MsrA) is a key endogenous antioxidative enzyme with longevity benefits in animals. Only very few approaches have been reported to enhance MsrA function. Recent reports indicated that the antioxidant capability of may involve Met oxidase activity facilities reaction reactive oxygen species (ROS). Herein, we used homology modeling approach search substrates for MsrA. We found dimethyl sulfide (DMS), main metabolite produced by marine algae, emerged as...
Dysfunctional autophagy and impairment of adult hippocampal neurogenesis (AHN) each contribute to the pathogenesis major depressive disorder (MDD). However, whether dysfunctional is linked aberrant AHN underlying MDD remains unclear. Here we demonstrate that expression nuclear receptor binding factor 2 (NRBF2), a component autophagy-associated PIK3C3/VPS34-containing phosphatidylinositol 3-kinase complex, attenuated in dentate gyrus (DG) under chronic stress. NRBF2 deficiency inhibits...
Physical exercise has beneficial effect on anxiety disorders, but the underlying molecular mechanism remains largely unknown. Here, it is demonstrated that physical can downregulate S-nitrosylation of gephyrin (SNO-gephyrin) in basolateral amygdala (BLA) to exert anxiolytic effects. It found level SNO-gephyrin significantly increased BLA high-anxiety rats and a downregulation at cysteines 212 284 produced effect. Mechanistically, inhibition by either Cys212 or Cys284 mutations surface expression GABA
Acid-sensing ion channels (ASICs) extensively exist in both central and peripheral neuronal systems contribute to many physiological pathological processes. The protein that interacts with C kinase 1 (PICK1) was cloned as one of the proteins interacting (PKC) colocalized ASIC1 ASIC2. Here, we used PICK1 knockout (PICK1-KO) C57/BL6 mice together whole cell patch clamp, calcium imaging, RT-PCR, Western blot, immunocytochemistry techniques explore possible change ASICs regulatory effects PKC on...
The adipocyte-derived hormone leptin and the pancreatic β-cell-derived insulin function as afferent signals to hypothalamus in an endocrine feedback loop that regulates body adiposity. They act hypothalamic centers modulate of specific neuronal subtypes, such neuropeptide Y (NPY) neurons, by modifying electrical activity. To investigate intrinsic activity these neurons their responses leptin, we used a combination morphological features immunocytochemical technique identify NPY arcuate...
Chronic stress induces altered energy metabolism and plays important roles in the etiology of depression, which glucocorticoid negative feedback is disrupted due to imbalanced receptor (GR) functions. The mechanism underlying dysregulation GR by chronic remains elusive. In this study, we investigated role AMP-activated protein kinase (AMPK), key enzyme regulating cellular metabolism, related signaling pathways stress-induced dysregulation. cultured rat cortical astrocytes, treatment...