About
Contact & Profiles
A5017824109
Research Areas
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
UNC Lineberger Comprehensive Cancer Center
2021
University of North Carolina at Chapel Hill
2021
We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating (mtDNA) replication initiation mammalian mitochondria. Transcription from light-strand promoter (LSP) is required both gene expression and generating RNA primers needed of mtDNA synthesis. In absence mtSSB, transcription LSP strongly up-regulated, but no are formed. Using deep sequencing mouse knockout model biochemical reconstitution experiments with pure proteins, we find that mtSSB necessary...
10.1126/sciadv.abf8631
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Science Advances
2021-07-02
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