Vitamin D deficiency could play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) as it may alter several crucial processes development and its complications, such pancreatic insulin secretion, peripheral resistance, persistence systemic „sterile” inflammation immune activation. also have antioxidant effect through inhibition free radicals generation. The reported study was designed with eligible consecutively recruited patients T2DM on standard metformin therapy...

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute NAFLD may vary, ongoing research is aimed at understanding specific roles different ILs in pathogenesis this condition. In addition, variations environmental factors genetics each individual can influence and/or NAFLD. lack clinical studies related potential therapeutic properties IL-1...

Considering the high prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate potential benefit determining markers oxidative stress, inflammation and dyslipidemia for prediction NAFLD, as estimated index (FLI) DM2.A total 139 DM2 (of them 49.9% females) were enrolled cross-sectional study. Anthropometric biochemical parameters, well blood pressure obtained. A FLI was calculated.Multivariate logistic regression...

The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels are associated with both newly diagnosed cases atrial fibrillation (AF). However, this article summarizes role in pathogenesis AF, which includes fibrinogen fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, inhibitor-1, platelet activation. Coagulation irregularities play a significant AF.

Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women showed contradictory results.Therefore, we aimed to evaluate relationship testosterone level Fatty Liver Index (FLI), as a surrogate marker for NAFLD, cohort of postmenopausal women.Material methods: A total 150 were included this cross-sectional study.Anthropometric biochemical parameters, well blood pressure, obtained.Non-alcoholic is assessed by...

We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) inflammation by calculation its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation glucoregulation subjects with prediabetes overt type 2 diabetes (T2D).

The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation the key underlying culprits for its onset progression. To gain deeper insight into these processes, we have evaluated several parameters, markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), 25-hydroxyvitamin D [25(OH)D] in IPF patients.Biochemistry analyses were...

Acute pancreatitis (AP) is a common inflammatory state characterized by clinical course that can lead to serious local and extrapancreatic organ malfunction failure. Interleukins (ILs) are biologically active glycoproteins primarily produced macrophages lymphocytes. According the literature, there many ILs. However, this article represents summary of role ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18,...

Abstract Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, mutual involvement redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant (TOS), antioxidant (TAS) and oxidative-stress index (OSI)] cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed investigate this potential relationship. A 122...

Although C-reactive protein (CRP) is among the best cardiovascular disease risk predictors, data regarding association of CRP and menopause are controversial. In this study, we measured by a high-sensitivity method (hsCRP), cholesterol, lipoproteins, triglycerides in normal overweight postmenopausal women.Body weight, height, waist circumference (WC), hsCRP, total high-density lipoprotein cholesterol (HDL-c), low-density (LDL-c), triglycerides, (a) were 30 weight 60 healthy...

Background Visceral adiposity index ( VAI ) and Lipid accumulation product LAP are novel visceral indexes, proposed for the evaluation of cardiometabolic risk in adult population. Considering contradictory results obtained from many studies so far, we aimed to examine potential benefit applicability , over simple anthropometric indices traditional lipid parameters individuals with type 2 diabetes mellitus DM 2). Methods A total 180 (of them 50% females) 119 controls who volunteered...

Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Therefore, we aimed evaluate influence lipid parameters on long-term glycemic control in DM2. Materials Methods: A total 275 sedentary DM2 (mean [±standard deviation] age 60.6 [±10.0] years) who volunteered participate this cross-sectional study were enrolled. Anthropometric (body weight, body hight,...

Excess salt and inadequate potassium intakes are associated with high cardiovascular disease (CVD). In Montenegro, CVD is the leading cause of death disability. There no survey that has directly measured consumption in Montenegro. The aim to estimate population explore knowledge, attitudes behaviour (KAB), amongst adult Podgorica. Random samples adults were obtained from primary care centres. Participants attended a screening including demographic, anthropometric physical measurements....

Aim: There are no studies regarding comparative analysis of serum biomarkers oxidative stress in patients with psoriasis (PsO) and atopic dermatitis (AD). We aimed to compare the redox homeostasis parameters PsO vs. AD an attempt find sensitive specific biomarker that could best reflect existence one these disease entities. Methods: Forty forty were consecutively included this cross-sectional study. Parameters homeostasis, i.e., pro-oxidants [malondialdehyde (MDA) advanced oxidation protein...