A5100682634- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- TGF-β signaling in diseases
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Medicinal Plant Pharmacodynamics Research
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Case Reports on Hematomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Acute Kidney Injury Research
- Pelvic and Acetabular Injuries
- Microbial Inactivation Methods
- Maternal and fetal healthcare
- Kruppel-like factors research
Sichuan University
2012-2023
Bridge University
2021
West China Second University Hospital of Sichuan University
2012-2020
Tulane University
2017
Wuxi People's Hospital
2017
Nanjing Medical University
2014-2016
Second Affiliated Hospital of Nanjing Medical University
2016
Huazhong University of Science and Technology
2009
Union Hospital
2009
Chemoresistance remains a major obstacle to effective treatment in patients with ovarian cancer, and recently increasing evidences suggest that miRNAs are involved drug-resistance. In this study, we investigated the role of regulating cisplatin resistance cancer cell line analyzed their possible mechanisms. We profiled differentially expressed cisplatin-resistant human A2780/DDP compared parental A2780 cells using microarray. Four abnormally were selected (miR-146a,-130a, -374a miR-182) for...
Proteinuria is involved in the development of tubular lesions and progressive loss renal function chronic kidney diseases via uncertain mechanisms. Growing evidence suggests a pathogenic role mitochondrial dysfunction diseases. Therefore, present study aimed to define roles mitochondria proteinuria-induced injury their underlying Using albumin-overload mouse model, we observed severe structure damage striking cell apoptosis. Furthermore, epithelial cells displayed E-cadherin expression...
Long non-coding RNAs are emerging to be novel regulators in gene expression. In current study, lncRNAs microarray and lncRNA-mRNA co-expression analysis were performed explore the alternation function of cervical cancer cells. We identified that 4750 (15.52%) differentially expressed SiHa (HPV-16 positive) (2127 up-regulated 2623 down-regulated) compared with C-33A (HPV negative), while 5026 (16.43%) HeLa (HPV-18 (2218 2808 respectively. There 5008 mRNAs 4993 HeLa, which all cataloged by GO...
Abstract Objective: To uncover the function of lncRNA NEAT1 in ovarian cancer (OC) cells and its mechanism. Methods: The expression patterns FGF9 human OC epithelial was determined. were transfected with sh-NEAT1, pcDNA3.1-NEAT1, miR-365 mimic, inhibitor or pcDNA3.1-NEAT1 + sh-NEAT1 before cell proliferation rate clone formation measured. After co-cultivated umbilical vein endothelial (HUVECs), Matrigel angiogenesis assay tested HUVECs; qRT-PCR Western blot expressions vascular growth factor...
MicroRNAs are essential for the maintenance of podocyte homeostasis. Emerging evidence has demonstrated a protective role microRNA-30a (miR-30a), member miR-30 family, in injury. However, roles other family members injury unclear. The present study was undertaken to investigate contribution miR-30e pathogenesis induced by aldosterone (Aldo), as well underlying mechanism. After Aldo treatment, reduced dose-and time-dependent manner. Notably, overexpression markedly attenuated Aldo-induced...
TGFBR2 serves as an initial regulator of the TGF-β signaling pathway, and loss or reduction its expression can lead to uncontrolled cell growth. This study was conducted further explore mechanism TGFBR2/SMAD4 on migration proliferation CC cells. Here, SMAD4 expressions in cells control were measured. The patterns verified TCGA database. After transfected with pcDNA3.1-TGFBR2 pcDNA3.1-SMAD4, cotransfected si-SMAD4, Co-IP utilized for identification interaction between SMAD4, CCK-8 assay...
Abstract Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage the histological types. presence aggressive pathologic risk factors following patients’ primary surgery may warrant use adjuvant radiotherapy. It important to weigh risks benefits using radiotherapy for each patient so as maximize their prognosis while minimizing treatment-related morbidity. Methods: A retrospective study was performed. consisted 97 patients...
To analyze the clinic-pathological characteristics of women with cervical cancers in southwestern China and discuss features prognosis young patients.A retrospective study was performed, which consisted 1,543 patients diagnosed cancer underwent treatment at West Second University Hospital between November 2005 December 2010. Among them, 154 surgical procedures 2008 were selected for a 5-year follow-up prognostic analysis.The proportion advanced FIGO stage aged over 35 years higher than or...
The aim of the present study was to discuss clinicopathological characteristics endometrial carcinoma in young females with polycystic ovary syndrome (PCOS), and review current literature. A total 9 patients histopathologically confirmed cancer PCOS at West China Second Hospital Sichuan University between December 2007 September 2013 were included. analyzed. age range 24-38 years (median age, 29), all cases had abnormal vaginal bleeding endometrioid adenocarcinoma most common...
HOXA distal transcript antisense RNA (HOTTIP), a critical oncogenic long non-coding RNA, has been reported to be aberrantly regulated in various cancer types. The present meta-analysis aimed investigate HOTTIP as potential clinical applicable prognostic biomarker malignant neoplasms. Literature collections were performed by searching the electronic databases, PubMed and Web of Science (up July 20, 2016). All relevant searches conducted identify association with overall survival (OS) rate. A...
<h3>Introduction/Background</h3> Long non-coding RNAs are emerging to be novel regulators in gene expression. In current study, lncRNAs microarray and lncRNA-mRNA co-expression analysis were performed explore the alternation function of cervical cancer cells. Our study might help understand interplay between coding genes anticipated oncogenic HPV proliferation, may missing links well-known tumor suppressor networks. <h3>Methodology</h3> The high-throughput was detect global mRNAs expression...
Objective To investigate the role of microRNA-709 (miR-709)in murine renal tubular epithelial cells with Cisplatin treatment and its underlying mechanism. Methods The were cultured in concentrations (0, 1, 5, 10, 20 μmol/L) for 24 h vitro, underwent 10 μmol/L stimulation at diffe-rent time points 2, 6, 12, h). Real-time fluorescence quantitative polymerase chain reaction (RT-PCR) was used to level miR-709.mPTC divided into a negative control group, miR-709 mimic inhibitor (INNC)group,...
Objective To investigate the effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on expression transformation growth factor-beta 1 (TGF-β1) phosphorylation Smad 3 in malignant melanoma cell line, A375. Methods Cultured A375 cells were classified into 5 groups, i.e. control group (no stimulation), ET-1 (stimulated with ET-1), + BQ123 (treated BQ123), BQ788 BQ788), ET-3 ET-3), to receive different stimulation. The working concentrations 0, 0.1, 1, 10, 100 nmol/L for ET-3, 10 μmol/L BQ788....
Phosphatidylinositol-3-kinase(P13K)signaling pathway participates in the regulation of many kinds cell biological behavior,e.g.,proliferation,differentiation,apoptosis and transport glucose.Recently,it has been revealed that signaling consisting class la P13K its downstream molecule protein kinase B(PKB/Akt)has a close relationship with occurrence development human malignant melanoma.The can regulate prolifemtion survival melanoma cells.The abnormality this not only cause transformation but...