A5003522912- Fungal and yeast genetics research
- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Fermentation and Sensory Analysis
- Genetic Neurodegenerative Diseases
- Pancreatic function and diabetes
- Plant Reproductive Biology
- Microbial Metabolic Engineering and Bioproduction
- Plant nutrient uptake and metabolism
- Biofuel production and bioconversion
University of Tennessee at Knoxville
2019-2023
During cytokinesis, fission yeast coordinates actomyosin ring constriction with septum ingression, resulting in concentric furrow formation by a poorly defined mechanism. We report that cells lacking the Cdc42 activator Gef1, combined an activated allele of formin, Cdc12, display non-concentric furrowing. Non-concentrically furrowing uneven distribution scaffold Cdc15 along ring. This suggests after assembly, uniform enables proper formation. find assembly is recruited to Arp2/3...
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum synthesis followed by digestion resulting cell separation. A recent report indicates that endocytosis is required for and The conserved GTPase Cdc42 membrane trafficking promotes endocytosis. activated Guanine nucleotide exchange factors (GEFs). GEFs have been shown promote timely initiation of proper morphology. Here we show the recruitment major primary synthesizing enzyme Bgs1 consequent constriction....
During cytokinesis, a series of coordinated events partition dividing cell. Accurate regulation cytokinesis is essential for proliferation and genome integrity. In fission yeast, these ensure that the actomyosin ring septum start ingressing only after chromosome segregation. How cytokinetic are remains unclear. The GTPase Cdc42 promotes recruitment certain cell wall-building enzymes whereas Rho1 activates enzymes. We show prevents early activation during yeast cytokinesis. Using an active...
Abstract Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum synthesis followed by digestion resulting cell separation. A recent report indicates that endocytosis is required for and The conserved GTPase Cdc42 membrane trafficking promotes endocytosis. activated Guanine nucleotide exchange factors (GEFs). GEFs have been shown promote timely initiation of proper morphology. Here we show the recruitment major primary synthesizing enzyme Bgs1 consequent...
Abstract Cytokinesis consists of a series coordinated multi-step events that partition dividing cell. Accurate regulation cytokinesis is essential for proliferation and genome integrity. In fission yeast, these ensure the actomyosin ring septum start ingressing only after chromosome segregation. How cytokinetic are remains unclear. The GTPase Cdc42 required delivery certain cell wall-building enzymes while Rho1 activation enzymes. Here we show prevents early during cytokinesis. Using an...