A5000049729- Veterinary Oncology Research
- Veterinary Equine Medical Research
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Gallbladder and Bile Duct Disorders
- Radiation Therapy and Dosimetry
- Pituitary Gland Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Fibroblast Growth Factor Research
- Pediatric Hepatobiliary Diseases and Treatments
- Trace Elements in Health
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Veterinary Orthopedics and Neurology
- Head and Neck Anomalies
- Soft tissue tumor case studies
- Histiocytic Disorders and Treatments
- Veterinary Pharmacology and Anesthesia
- Prion Diseases and Protein Misfolding
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and related cancers
- Biliary and Gastrointestinal Fistulas
Yamaguchi University
2020-2024
Gifu University
2023
Nihon University
2018-2022
The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 (ca-4F12-E6) and evaluated its therapeutic properties dogs with advance-staged oral malignant melanoma (OMM), however, their effects on other types canine tumors remain unclear.
Atlanto-axial instability is a common disease that affects toy-breed dogs. Most cases of atlanto-axial are congenital. Furthermore, patients with predisposed to other concurrent diseases. Therefore, this study aimed retrospectively determine the presence diseases in using imaging data and analyze relationship between clinical parameters incidence complex malformations. The findings 41 dogs diagnosed were analyzed their medical records data. Occipital dysplasia (17/27), atlanto-occipital...
Abstract OBJECTIVE To evaluate the clinical feasibility and usefulness of measuring shunt fraction (SF) hepatic perfusion with CT in dogs a single extrahepatic portosystemic (EPSS). ANIMALS 36 client-owned EPSS. PROCEDURES Dogs EPSS referred for treatment between February 2016 May 2017 were eligible trial. Shunt type, SF, determined each dog 320-row multidetector scanner, surgical was performed by veterinary surgeon. Differences results grouped according to age (< 3 years vs ≥ years),...
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm, and widespread metastasis occurs with a fatal outcome. HS involving the central nervous system relatively uncommon. Spinal cord necrosis, very rare condition, could be induced by ischemia or infarction. Here, we report dog progressing non-ambulatory tetraparesis spinal necrosis caused HS.A 9-year-old male Labrador Retriever was presented tetraparesis. CT imaging revealed lysis of spinous process T7 ring-shaped lesion surrounding...
Micro-endoscopic discectomy (MED) or microscopic (MD) have been performed for disc herniation in humans. The purpose of this study was to compare the invasiveness hemilaminectomy dogs between approach using a cylindrical retractor MED/MD and conventional open surgical approaches dogs. First, as preliminary studies, we analyzed suitability vertebral body small medium-sized on X-ray computed tomographic images three-dimensional analysis software, confirmed that it possible bone window an...
A 1-year-old spayed female Miniature Schnauzer had chronic hyponatremia, accompanied by polyuria and polydipsia. Blood tests urinalysis revealed severe low plasma osmolality with euvolemia, increased sodium excretion in urine. Hypothyroidism hypoadrenocorticism were ruled out as causes. These findings led to the diagnosis of syndrome inappropriate secretion antidiuretic hormone (SIADH). Magnetic resonance imaging (MRI) showed dilation lateral ventricles, indicating hydrocephalus. Tolvaptan,...
Microsatellite instability (MSI) is a type of genomic caused by mismatch repair deficiency (dMMR) in tumors. Studies on dMMR/MSI are limited, and the relationship between dMMR MSI unknown tumors dogs.We aimed to identify frequency tumor evaluate dogs.In total, 101 dogs with 11 types malignant were included.We extracted DNA from fresh normal tissues. Twelve microsatellite loci both amplified PCR detected capillary electrophoresis. Each (MS) was defined as if difference product size detected....
A male 25-month-old Dalmatian dog attended our veterinary hospital because of anorexia and high circulating liver enzyme activities. Abdominal computed tomography showed a slightly small with rounded edges, laparoscopic examination that the was yellowish. Histopathological revealed multifocal necrosis hepatocytes severe chronic hepatitis. Rhodanine staining copper accumulation in quantitative analysis content substantial (10.3 mg/g dry mass), suggesting diagnosis copper-associated Previously...
Transcatheter arterial embolization (TAE) and transcatheter chemoembolization (TACE) are standard treatments for advanced hepatocellular carcinoma (HCC) particularly unresectable tumors or liver metastases in humans. However, reports on TACE used veterinary medicine few. This study aimed to evaluate the feasibility safety of drug-eluting bead transarterial (DEB-TACE). We performed DEB-TACE four clinically normal dogs pharmacokinetically compared results against hepatic infusion (HAI)...
Gallbladder mucocele (GM) is a common extrahepatic biliary disease recognized in dogs and defined as the expansion extension of gallbladder by an accumulation semi-solid bile or acid. Histopathological diagnosis necrotizing cholecystitis transmural coagulative necrosis wall shows poor prognosis. Conversely, histopathological with partial necrotic findings often achieved. We hypothesized that primary lesion ischemic necrosis. Therefore, we investigated relationship between necrosis/ their...
A 15‐year‐old spayed female mongrel presented with anorexia and an abdominal mass. The mass originated from the gall bladder was surgically resected along divisionectomy of central hepatic division. Paroxysmal hypertension tachycardia were noted during manipulation Following resection, arterial blood pressure decreased significantly. Histopathological analysis confirmed a diagnosis neuroendocrine neoplasm. Immunohistochemical staining for synaptophysin chromogranin yielded diffuse strong...
Dogs' nephroblastoma of the spinal cord is a rare neoplastic disease, with few reports long-term survival after surgery. We experienced that surgical treatment postoperative radiation therapy for in dog resulted 11 years.The patient presented to our veterinary hospital because progressive hindlimb paralysis. Based on diagnostic imaging, she was diagnosed thoracolumbar tumor and treated The gross tissue removed laminectomy, followed by using orthovoltage equipment. histopathological features...
Angiogenesis plays an important role in the proliferation and metastasis mechanisms of malignant tumors. Vascular endothelial growth factor (VEGF), a group cytokines that contribute to angiogenesis vasculogenesis. This study aimed investigate serum VEGF-A concentrations dogs with various proliferative diseases. A total 202 were histopathologically diagnosed diseases included study. Serum measured using enzyme-linked immunosorbent assay. Median as follows: healthy dogs, 4 pg/ml [0-21 pg/ml];...
Background: For optimal treatment, it is important to maintain multi-leaf collimator (MLC) transmission in intensity-modulated radiation therapy (IMRT). However, adjustment of transmissions has not been reported veterinary medicine. Aim: This study aimed demonstrate that appropriate MLC parameter for IMRT using 4- and 6-MV energy can reduce the need quality assurance revalidation real companion animal clinical cases. Methods: The parameters (leaf leaf offset) treatment planning system were...
This study investigated the direct effects of non-steroidal anti-inflammatory drugs (NSAIDs) and atrial natriuretic peptide (ANP) on canine-derived vascular endothelial cells (VECs). VECs were isolated cultured from canine arteries veins. The mRNA expressions growth factor receptor 2, cyclooxygenase-2, 1 detected in VECs. viability was reduced a dose-dependent manner by meloxicam, carprofen, robenacoxib. By contrast, dose escalations ANP had only marginal influence NSAIDs may potentially...
An 11-year-old male toy poodle with neurological symptoms was diagnosed a macroscopic pituitary tumor, which produced adrenocorticotropic hormone. Radiation therapy linear accelerator performed for the and resulted in good local tumor control. However, serum endogenous hormone concentrations were uncontrollable even after disappeared. Abdominal computed tomography revealed splenic masses, splenectomy performed. Histopathological examination of surgical specimen showed cells eosinophilic...
Inflammatory mammary carcinoma (IMC) is a rare disease with poor prognosis and one affecting dogs. breast (IBC) subtype of malignant cancer in humans high degree malignancy similarly prognosis. Since the clinical symptoms prognoses both are similar, canine IMC has been considered as model human IBC. In this study, we newly established stable IMC-derived cell line from patient at Yamaguchi University Animal Medical Center Japan.The was female toy poodle presenting an inflamed gland, which...
Background: Intensity-modulated radiotherapy (IMRT), which allows generating steep dose gradients, is a beneficial treatment for companion animals with adjacent target and risk organs. IMRT essential high setup accuracy avoiding overdose to organs, optimal important evaluating the of animals. Aim: To use an immobilization device evaluate errors in Materials methods: We calculated 386 (dogs cats; 3261 registration images) that underwent between 2016 2022. The were immobilized customized bite...
Third-degree atrioventricular block (AVB) is usually permanent, with transient cases being rare. Cats third-degree AVB. It had been not reported in detail.A 9.3-year-old, male shorthair cat was evaluated for possible nervous disease resulting from otitis interna. Under propofol and isoflurane anesthesia, this developed a Isoproterenol administered by continuous infusion to increase its heart rate. During recovery, rate returned sinus bradycardia together first-degree AVB without medical...
Cystine-glutamate transporter (xCT) is a plasma membrane that imports cystine and indirectly contributes to the oxidative stress resistance associated with increased intracellular glutathione levels. Canine adipose-derived stem cells (CADSCs) include an xCT-positive subpopulation show relatively low expression of osteogenic markers during in vitro differentiation. Sulfasalazine (SSZ), drug used treat rheumatoid arthritis, suppresses xCT cancer cells. In this study, we found SSZ treatment at...
前胸部腫瘤を主訴に、12歳齢、去勢雄のチワワが来院した。初診時に患者は無症状であったが、約5ヶ月間で腫瘤が増大するとともに発咳を呈するようになった。第184病日に胸骨正中切開による前胸部腫瘤摘出術を実施した。腫瘤は前大静脈や気管を圧迫し、周囲組織と癒着していた。摘出した腫瘤の内部は広範囲で壊死が起こっていた。病理組織学的診断は甲状舌管遺残腺腫であり、腫瘤摘出後に患者の臨床症状は改善し、良好な経過が得られた。本疾患は犬の前縦隔腫瘍の鑑別診断として考慮する必要があると考えられた。