A5080889328- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Renal cell carcinoma treatment
- Renal and related cancers
- DNA Repair Mechanisms
- RNA regulation and disease
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Rheumatoid Arthritis Research and Therapies
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Protein Tyrosine Phosphatases
- Ferroptosis and cancer prognosis
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- PARP inhibition in cancer therapy
- Thyroid Cancer Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Plant Genetic and Mutation Studies
- Cell Adhesion Molecules Research
Adam Mickiewicz University in Poznań
2016-2025
University of Fukui
2023
Poznan University of Medical Sciences
2016-2023
Institute of Molecular Biology and Biotechnology
2012-2016
High Throughput Biology (United States)
2013
Faculty (United Kingdom)
2012
Leiden University Medical Center
2005-2007
Erasmus MC
2002-2003
Erasmus University Rotterdam
2002-2003
VHL inactivation is the most established molecular characteristic of clear cell renal carcinoma (ccRCC), with only a few additional genes implicated in development this kidney tumor. In recently published ccRCC gene expression meta-analysis study we identified number deregulated limited information available concerning their biological role, represented by transcripts belonging to transmembrane proteins family (TMEMs). TMEMs are predicted be components cellular membranes, such as...
Collectively our results strongly suggest that the alternative IFNα-mediated, STAT2/IRF9 dependent signaling pathway can induce a prolonged ISGF3-like transcriptome and generate an antiviral response analogous to ISGF3, independent of STAT1. Moreover, existence “STAT2/IRF9-specific” target genes predicts novel role STAT2 in IFNα signaling.
Homologous recombination is a versatile DNA damage repair pathway requiring Rad51 and Rad54. Here we show that mammalian Rad54 paralog, Rad54B, displays physical functional interactions with are similar to those of While ablation in mouse embryonic stem (ES) cells leads mild reduction homologous efficiency, the absence Rad54B has little effect. However, both dramatically reduces efficiency. Furthermore, protects ES from ionizing radiation interstrand cross-linking agent mitomycin C....
Interferons (IFNs) induce gene expression by phosphorylating latent transcription factors belonging to the signal transducer and activator of (STAT) family, mediated janus kinases (Jaks). STAT dimers directly activate genes containing IFNgamma activation site (GAS) DNA element, with different proteins displaying slightly intrinsic binding specificities. The combinatorial association STATs additional adaptor protein interferon regulatory factor (IRF)9 expands range enhancer elements that can...
Signal integration between IFNγ and TLRs in immune cells has been associated with the host defense against pathogens injury, a predominant role of STAT1. We hypothesize that STAT1-dependent transcriptional changes vascular involved cross-talk TLR4, reflect pro-atherogenic responses human atherosclerosis. Genome-wide investigation identified set genes were synergistically affected by interactions TLR4 VSMCs. These included chemokines Cxcl9, Ccl12, Ccl8, Ccrl2, Cxcl10 Ccl5, adhesion molecules...
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ) and dendritic cells (DC) play crucial role in vascular inflammation atherosclerosis. Interferon (IFN)α, IFNγ Toll-like receptor (TLR)4 activate pro-inflammatory gene expression are pro-atherogenic. Gene regulation many genes has shown to rely on Signal Integration (SI) between IFNs TLR4 through combinatorial actions...
To understand in detail the transcriptional and functional overlap of IFN-I- IFN-II-activated responses, we used an integrative RNAseq-ChIPseq approach Huh7.5 cells characterized genome-wide role pSTAT1, pSTAT2, IRF9 IRF1 time-dependent ISG expression. For first time, our results provide detailed insight timely steps IFNα- IFNγ-induced transcription, which pSTAT1- pSTAT2-containing ISGF3 GAF-like complexes are recruited to individual or combined ISRE GAS composite sites a phosphorylation-...
The homologous recombination (HR) DNA repair pathway participates in telomere length maintenance yeast but its putative role at mammalian telomeres is unknown.Mammalian Rad54 part of the HR machinery, and Rad54-deficient mice show a reduced capability.Here, we that also significantly shorter than wild-type controls, indicating activity plays an essential mammals.Rad54 deficiency resulted increased frequency end-to-end chromosome fusions involving compared to suggesting capping.Finally, study...
During infections and inflammation, plasmacytoid dendritic cells (pDCs) are the most potent type I interferon (IFN-I)–producing cells. However, developmental origin of pDCs signals dictating pDC generation remain incompletely understood. Here, we report a synergistic role for IFN-I Flt3 ligand (FL) in development from common lymphoid progenitors (CLPs). Both conventional DCs (cDCs) were generated CLPs response to FL, whereas required higher concentrations FL concurrent signaling. An absence...
Inflammation plays an important role in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of atherosclerosis. Signal transducer activated transcription 1 (STAT1) has been identified as a point convergence for cross talk between pro-inflammatory cytokine interferon γ (IFNγ) Toll-like receptor-4 (TLR4) ligand LPS immune cells. However, there is no information available on STAT1 TLR4-mediated progression atherosclerosis potential synergism...